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Öğe Does Cardiologist Lead Enhanced Heart Failure Education and Follow-up Program Affect Cardiovascular Mortality Rate?: Hit-Point(Lippincott Williams & Wilkins, 2013) Cavusoglu, Yuksel; Zoghi, Mehdi; Eren, Mehmet; Bozcali, Evin; Kozdag, Guliz; Senturk, Tuncay; Alicik, Guray[Abstract Not Available]Öğe Effect of Cardiac Resynchronization Therapy on Thyroid Function(Wiley-Blackwell, 2011) Celikyurt, Umut; Agacdiken, Aysen; Geyik, Bilal; Kozdag, Guliz; Vural, Ahmet; Ural, DilekBackground: Heart failure patients frequently have thyroid function abnormalities. Cardiac resynchronization therapy (CRT) is a major treatment for patients with advanced chronic heart failure. We aimed to investigate the effects of CRT on thyroid functions.Öğe Post-discharge heart failure monitoring program in Turkey: Hit-PoinT(Aves, 2017) Cavusoglu, Yuksel; Zoghi, Mehdi; Eren, Mehmet; Bozcali, Evin; Kozdag, Guliz; Senturk, Tunay; Alicik, GurayObjective: The aim of this study was to assess the efficacy and feasibility of an enhanced heart failure (HF) education with a 6-month telephone follow- up program in post-discharge ambulatory HF patients. Methods: The Hit-Point trial was a multicenter, randomized, controlled trial of enhanced HF education with a 6-month telephone follow-up program (EHFP) vs routine care (RC) in patients with HF and reduced ejection fraction. A total of 248 patients from 10 centers in various geographical areas were randomized: 125 to EHFP and 123 to RC. Education included information on adherence to treatment, symptom recognition, diet and fluid intake, weight monitoring, activity and exercise training. Patients were contacted by telephone after 1, 3, and 6 months. The primary study endpoint was cardiovascular death. Results: Although all-cause mortality didn't differ between the EHFP and RC groups (p=NS), the percentage of cardiovascular deaths in the EHFP group was significantly lower than in the RC group at the 6-month follow up (5.6% vs. 8.9%, p=0.04). The median number of emergency room visits was one and the median number of all cause hospitalizations and heart failure hospitalizations were zero. Twenty-tree percent of the EHFP group and 35% of the RC group had more than a median number of emergency room visits (p=0.05). There was no significant difference regarding the median number of all-cause or heart failure hospitalizations. At baseline, 60% of patients in EHFP and 61% in RC were in NYHA Class III or IV, while at the 6-month follow up only 12% in EHFP and 32% in RC were in NYHA Class III or IV (p=0.001). Conclusion: These results demonstrate the potential clinical benefits of an enhanced HF education and follow up program led by a cardiologist in reducing cardiovascular deaths and number of emergency room visits with an improvement in functional capacity at 6 months in post-discharge ambulatory HF patientsÖğe Post-discharge Heart Failure Monitorization Program in Turkey: Hit-PoinT(Elsevier Science Inc, 2013) Cavusoglu, Yuksel; Zoghi, Mehdi; Eren, Mehmet; Bozcali, Evin; Kozdag, Guliz; Senturk, Tuncay; Alicik, Guray[Abstract Not Available]Öğe Relationship Between Endothelial Functions and Acetylsalicylic Acid Resistance in Newly Diagnosed Hypertensive Patients(Wiley, 2012) Sahin, Tayfun; Celikyurt, Umut; Geyik, Bilal; Oner, Gokhan; Kilic, Teoman; Bildirici, Ulas; Kozdag, GulizBackground: We aimed to investigate the effects and dose dependency of aspirin on endothelial functions and prevalence of aspirin resistance in newly diagnosed hypertensive patients without previous drug therapy and development of cardiac complications. Hypothesis: Acetylsalicyclic acid improves endothelial function. Methods: Fifty-eight hypertensive patients and 61 healthy subjects in the control group were included in the study. Endothelial functions of the patient and control groups were evaluated with brachial artery examination. Patient and control groups were divided into 2 groups. A total of 100 mg and 300 mg of aspirin were given to the separate groups for 1 week. After 1 week, endothelial functions were reevaluated and aspirin resistance examined with a platelet function analyzer (PFA-100; Dade Behring, Marbourg, Germany). Results: Baseline flow-mediated dilatation (FMD) change percent in hypertensive patients was 9.8%, and it was significantly lower than in the control group (12%) (P < 0.001). Frequency of acetylsalicylic acid (ASA) resistance was 20% and 26% in control and hypertensive patient groups, respectively (P = not significant). ASA resistance was 28% and 24% in 100 mg and 300 mg in hypertensive patients, respectively (P = not significant). FMD change percent increased both in the control and hypertensive groups after ASA treatment from 12.4% to 13.3% and 9.8 % to 11.9 %, respectively. FMD percentage change was significantly increased in hypertensive patients irrespective of ASA resistance (P = 0.02, for ASA resistance [+]; P < 0.012, for ASA resistance [-]). Conclusions: Endothelial functions were impaired more in hypertensive patients compared to the control group. Endothelial functions were improved with all ASA doses in hypertensive patients irrespective of ASA resistance. The authors have no funding, financial relationships, or conflicts of interest to disclose.