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Öğe Assessment of sympathetic skin response to acne vulgaris(2017) Polat, Ayşegül; Korkmaz, Selma; Özlece, Hatice KöseAcne vulgaris (AV) is a common pilosebase unit disease characterized by peripheral inflammation. Because it is associated with the peripheral nervous system, the cranial nervous system and the autonomic nervous system, the skin is a neuroimmunoendocrine organ. Various neuroendocrine hormones and catecholamines are also released by keratinocytes, which stimulate inflammation in the pilosebase unit. In this study, sympathetic skin response (SSR) evaluating the sympathetic nervous system function as a reflex against internal and external stimuli in AV will be evaluated. 31 AV patients (mean age: 22.48 ± 2.35, 20 female, 11 male) and 29 healthy volunteers (mean age: 23.19 ± 1.27, 18 female, 11 male) between the ages of 18-30 were included in the study. All patient and control groups were questioned about detailed disease and medication intake history. Dermatologic examination was performed by a single experienced dermatologist, and global acne score (GAS) was calculated. For SSR measurement, both median nerve were warned separately on both wrists. The frequency filters is set to 0.5-2000 Hz and the analysis time is set to about 10 seconds. The SSR latencies were recorded in seconds (s) and the amplitudes were recorded in millivolts (mV). The mean age and sex of the groups were similar (p> 0,05, for each). There was no significant difference between AV and healthy control groups in terms of SSR latencies and amplitudes in both extremes ((p> 0.05, for each) AV patients had a mean GAS of 15.61. There was no correlation between GAS and latency and amplitude values of both extremities in AV patients (p> 0.05). As a result, it was found that SSR did not differ from normal people in AV cases. Changes in the autonomic nervous system in AV should be evaluated with more sensitive testsÖğe BRAF V600 Mutation Profile of Metastatic Melanoma in the Thrace Region of Turkey(De Gruyter Poland Sp Zoo, 2018) Can, Nuray; Tastekin, Ebru; Deniz Yalta, Tulin; Sut, Necdet; Korkmaz, Selma; Usta, Ufuk; Oz Puyan, FulyaObjective: BRAF is the most common mutation in melanoma. The most common subtype is BRAF V600E, followed by V600K. Initially, the authors aimed to investigate whether clinicopathological features of melanoma are associated with BRAF mutations. We then aimed to present the relationships between the clinicopathological features and the mutated subtype (V600E vs V600K). Material and Method: 61 patients with metastatic malignant melanoma (affecting the lymph node or other distant sites) were selected. Patient data regarding age at the time of diagnosis, sex, metastatic site (lymph node, distant metastasis or both) and primary tumour site were obtained from the hospital's database. Tissue samples containing at least 30% tumour cells were isolated from the specimens of 61 patients (24 samples from primary tumours and 37 from metastatic foci) for BRAF analysis. Comparisons between the BRAF V600 mutation and clinicopathological and histopathological features were performed. Results: BRAF V600 mutation was detected in 34 (55.7%) patients. The subtype was BRAF V600E in 22 (64.7%) patients, BRAF V600K in 11(32.4%) patients and BRAF V600R in 1(2.9%) patient. The crucial results of the present study may be summarized as follows: i) BRAF V600 mutation was more common in older patients and tumors with BRAF V600 mutation revealed necrosis and LVI more commonly than wild-type tumors, ii) BRAF V600K mutation was more common in older patients and BRAF V600K mutated tumors exhibited ulceration more commonly than tumors with BRAF V600E mutation (close to significant). Conclusion: The BRAF V600 mutation may have interactions with prognostic clinicoptahological features of melanoma including necrosis and lymphovascular invasion. V600K mutation may be more common than expected and may have different associations with properties of the tumor such as tumor ulceration and patient age. Investigation of the mutated subtype of the BRAF gene may therefore reveal more detailed data about the management of melanoma and may also prevent missing of candidates for BRAF inhibitor therapies.Öğe Calprotectin can play an inflammatory role in acne vulgaris(Termedia Publishing House Ltd, 2018) Korkmaz, Selma; Ficicloglu, Sezin KuruIntroduction: Acne vulgaris (AV) is a chronic inflammatory disorder of the pilosebaceous unit. Although various mechanisms have been indicated in the etiopathogenesis of acne vulgaris, the exact pathophysiology is still unknown. Aim: To investigate the level of calprotectin in acne vulgaris and its levels relationship with disease severity. Material and methods: A total of 66 AV patients, who were divided into 33 mild and 33 moderate-severe cases, and 30 healthy controls were enrolled in the study. Disease severity was assessed using the Global Acne Score. According to this scale, patients whose Global Acne Score was 1-18 had mild acne, those with a score of 19-30 had moderate acne, those with a score of 31-38 had severe acne, and those with a score greater than 39 had very severe acne. Serum calprotectin levels of all participants were measured by enzyme-linked immunosorbent assay method. Results: The serum calprotectin levels in the moderate-severe AV group were significantly higher than that of the mild AV group (p < 0.001). In addition, the scrum calprotectin level in the mild AV group was significantly higher than that of the healthy control group (p = 0.047). However, in the Spearman's correlation analysis, the scrum calprotectin level and GAS were not correlated in AV patients (p = 0.171, r = 0.179). Conclusions: Serum calprotectin levels are increased in mild and moderate AV patients.Öğe Effects of IVIG and Pulse Steroid Therapy in a Case of Allopurinol Induced DRESS Syndrome(Aves Press Ltd, 2018) Korkmaz, Selma; Gunay, Elif; Can, Nuray; Ficicioglu, Sezin; Piskin, SuleymanDrug Reaction with Eosinophilia and Systemic Symptoms (DRESS) is a drug reaction that causes peripheral eosinophilia and primarily renal and hepatic insufficiency and dysfunction of other visceral organs with skin rash as noticeable symptom. Early diagnosis and discontinuation of the culprit drug along with rapid treatment are required to reduce mortality rate. Herein, a case of allopurinol-induced DRESS syndrome is presented in which the patient was resistant to medium dose systemic steroid therapy and was treated with pulse steroid and IVIG treatment successfully. Pulse steroid therapy may be an alternative treatment option in refractory DRESS syndrome.Öğe Elevated serum levels of 8-hydroxy-2-deoxyguanosine in mild-moderate acne vulgaris(2018) Korkmaz, Selma; Özgün, ErayAcne vulgaris (AV) is a chronic inflammatory disease of the pilosebaceous unit. Although some mechanisms have been suggested in the etiopathogenesis of AV in several studies, they have not yet been clarified. This study aims to investigate the level of 8-hydroxy-2’-deoxyguanosine (8-OHdG) in acne vulgaris and its relationship with disease severity. Thirty-five patients with mild to moderate acne vulgaris and 30 healthy control participants were included in the study. The clinical severity of AV was determined by using the global acne score (GAS). The 8-OHdG level was measured by an enzyme-linked immunosorbent assay (ELISA). Total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI) scores were measured as oxidative stress markers. Levels of 8-OHdG were higher in AV compared to healthy controls (P = 0.036). A strong positive correlation between GAS and 8-OHdG was found in those with AV (p = 0.007, r = 0.444). And while TAS and TOS levels were significantly lower in AV patients, OSI levels were found to be significantly higher compared to healthy controls (p <0.001, p <0.001, and p = 0.036, respectively). The level of serum 8-OHdG is elevated in mild to moderate AV and this elevation become evident with the increase of disease activity.Öğe Gaziantep Üniversitesi Tıp Fakültesi Leishmaniasis Tanı ve Tedavi Merkezine Başvuran Kutanöz Leishmaniasis Olgularının Değerlendirilmesi(2015) Korkmaz, Selma; Özgöztaşı, Orhan; Kayıran, NuriyeAmaç: Kutanöz Leishmaniasis (KL) Leishmania türü protozoon parazitlerin oluşturduğu atrofik skarlarla iyileşen bir hastalık tablosudur. Son yıllarda Gaziantep'de Suriye iç savaşı sonrasında KL olgularında dramatik bir artış gözlenmiştir. Bu çalışmanın amacı Gaziantep Üniversitesi Tıp Fakültesi Leishmaniasis tanı ve tedavi birimine başvuran KL tanılı hastaların epidemiyolojik özelliklerini değerlendirmektir.Yöntemler: 1.4.2013 ve 1.4.2014 yılları arasında Gaziantep'de Leishmaniasis tanı ve tedavi merkezine başvuran 635 KL hastası retrospektif olarak değerlendirildi. Hastaların yaş, cinsiyet, lezyonun yerleştiği bölge, lezyon sayısı, lezyonun süresi ve lezyonun ortaya çıktığı ay değerleri kaydedilerek uygun istatistiksel analiz ile değerlendirildi.Bulgular: Hastaların 67 (%10,6)'si Türkiye, 568 (%89,4)'i Suriye uyrukluydu. Hastaların 299 (%47,1)'u kadın, 336 (%52,9)'sı erkekti. Vakaların büyük kısmı 5-9 (n=140, %22) ve 10-19 (n=168, %26,5) yaşlar arasında olup tüm vakaların %66'sını 20 yaş altındaki bireyler oluşturmaktaydı. Vakaların aylara göre dağılımına bakıldığında en az vaka temmuz (n=14, %2,2) ve ağustos (n=13, %2,0) aylarında gözlenirken, en fazla vaka ocak (n=122, %19,2) ve şubat (n=106, %16,7) aylarında görüldü.Sonuç: Kutanöz Leishmaniasis her yaş ve cinsiyetteki bireyleri etkilemekte olup düzenli sağlık taramaları ve bu konuda topluma gerekli eğitimin verilmesi önem arz etmektedirÖğe Impact of smoking on disease severity in patients with plaque type psoriasis(Deri Zuhrevi Hastaliklar Dernegi, 2015) Kayiran, Nuriye; Korkmaz, Selma; Ozgoztasi, OrhanBackground and Design: Psoriasis is a chronic enflammatory systemic disease involving skin, scalp, nails and joints and is characterized by remission and activation periods. Although the etiopathogenesis of psoriasis has not been fully elucidated, many genetic and environmental factors are believed to have a role in the development of the disease. Obesity, smoking, family history of psoriasis, repetitive physical traumas and stress are the factors thought to affect the severity and progress of the disease. In this study, we aimed to investigate the effects of smoking on the clinical severity of psoriasis in patients with chronic plaque psoriasis. Materials and Methods: Three hundred outpatients with chronic plaque-type psoriasis were enrolled in the study. Data on age, gender, family history, smoking history, educational status, history of chronic illness, and psoriasis area severity index (PASI) scores were recorded for each patient. The effects of these factors on PASI were evaluated. Results: Current smokers, never smokers and former smokers were compared in terms of disease severity. The median PASI values of current smokers and never smokers were compared. The mean PASI value was statistically significantly higher in smokers (p=0.049). In multiple logistic regression analysis, it was detected that the risk of moderate and severe disease increased by male sex 2 times, by family history 2.3 times, and by smoking period above 20 years, 10 times. In smokers of more than 1 pack a day, this risk further increased. Conclusion: On the basis of these data, it may be concluded that smoking affects the severity of disease significantly. In addition to amount of daily cigarette consumption, smoking period was shown to have an effect on the severity of disease. Elimination of risk factors such as smoking, which appears to increase the severity of diseases, may be helpful in the management of psoriasis.Öğe Metabolic Syndrome May Exacerbate Macular and Retinal Damage in Psoriasis Vulgaris(Taylor & Francis Inc, 2019) Korkmaz, Selma; Guclu, Hande; Hatipoglu, Esra Sueheda; Ficicioglu, Sezin; Gurlu, Vuslat; Ozal, Sadik AltanPurpose: To evaluate whether cases with both psoriasis and metabolic syndrome are prone to retinal and macular changes. Materials and Methods: A total of 174 eyes of 87 subjects were evaluated. Of the 87 subjects, 24 had psoriasis, 19 had psoriasis and metabolic syndrome, 18 had metabolic syndrome only and 26 were healthy subjects. Biochemical analysis, anthropometric, blood pressure and optical coherence tomography measurements and thickness analysis were obtained for each case. Results: The superior retinal nerve fibre layer thickness was significantly lower in the psoriasis and metabolic syndrome group than in the psoriasis group. For all parafoveal quadrants, the ganglion cell complex thickness was statistically significantly lower in the psoriasis group than in the healthy group. The central macula was thinnest in the healthy group among the four groups. Conclusions: Psoriasis can cause retinal changes, and metabolic syndrome may cause additional damage in the retina and macula in cases with psoriasis.Öğe Serum adropin levels in psoriasis vulgaris and its relation with metabolic parameters(Tubitak Scientific & Technological Research Council Turkey, 2019) Korkmaz, Selma; Sayilan Ozgun, GulbenBackground/aim: Adropin is a peptide-structure hormone that plays a role in preventing the development of insulin resistance, which has been linked to obesity and metabolic regulation. The purpose of this study is to assess serum adropin levels and their relationship with metabolic parameters in psoriasis vulgaris patients both with and without metabolic syndrome (MetS). Materials and methods: Fifty-three patients and 26 healthy controls were included in this study. Serum adropin levels, fasting blood glucose, fasting serum insulin, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, total cholesterol, and triglyceride levels of all participants were analyzed. Enzyme-linked immunosorbent assay was used to measure serum adropin levels. Results: Serum adropin levels were 2.94 +/- 0.56 ng/mL in psoriatic patients without MetS, 2.49 +/- 0.77 ng/mL in psoriasis patients with MetS, and 3.37 +/- 10.71 ng/mL in the control group. Multivariate logistic regression analysis was used to evaluate adropin decreases in psoriasis patients as an independent predictor of the presence of MetS. Conclusion: The serum levels of adropin in psoriasis patients were significantly lower in the presence of MetS, and this decrease was more prominent than in those without MetS. Adropin may be a contributing factor for metabolic disorders and the development of MetS in psoriasis patients.Öğe Serum osteopontin levels in patients with psoriasis vulgaris and its relation with oxidative stress(Galenos Publ House, 2023) Kilinc, Cem; Korkmaz, Selma; Ozgun, Gulben Sayilan; Ficicioglu, Sezin Kuru; Piskin, SuleymanBackground and Design: Oxidative stress is known to play a role in the etiopathogenesis of psoriasis. Recent data suggest that osteopontin (OPN) can also play a role in the pathogenesis of psoriasis. In the current study, OPN levels and oxidative stress were evaluated in patients with psoriasis.Materials and Methods: The study included 61 patients with psoriasis and 62 healthy controls. The OPN levels, total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) were measured using serum. The disease severity was evaluated using the psoriasis area and severity index (PASI).Results: No statistically significant differences in OPN, TAS, and OSI values were identified between the psoriasis and control groups. A negative correlation was found with the TAS. There was no statistically significant correlation between the PASI score and OPN, TAS, TOS, and OSI values.Conclusion: We did not find a statistically significant correlation between OPN levels and oxidative stress in patients with psoriasis. We believe that larger and more detailed studies are needed to highlight the role of OPN and oxidative stress in the etiopathogenesis of psoriasis.
