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Öğe Evaluation of hearing in children with autism by using TEOAE and ABR(Sage Publications Ltd, 2007) Tas, Abdullah; Yagiz, Recep; Tas, Memduha; Esme, Meral; Uzun, Cem; Karasalihoglu, Ahmet RifatAssessment of auditory abilities is important in the diagnosis and treatment of children with autism. The aim was to evaluate hearing objectively by using transient evoked otoacoustic emission (TEOAE) and auditory brainstem response (ABR). Tests were performed on 3 0 children with autism and 15 typically developing children, following otomicroscopy and tympanometry. The children with autism were sedated before the tests. Positive emissions and normal hearing level at ABR were obtained in both ears of all children in the control group and of 25 children with autism. TEOAE and ABR results varied in the remaining five children with autism. The mean III-V interpeak latencies (IPLs) in both ears of children with autism were longer than those in the control group. Hearing loss may be more common in children with autism than in typically developing children.Öğe Frequency of Epstein-Barr virus and human papilloma virus in patients with nasopharyngeal carcinoma(Springer, 2020) Altekin, Ilhan; Tas, Abdullah; Yalcin, Omer; Guven, Selis Gulseven; Aslan, Zulkar; Adali, Mustafa Kemal; Karasalihoglu, Ahmet RifatPurpose Nasopharyngeal cancer is a type of malignancy originating from the epithelial cells lining the nasopharynx. In genetic and environmental factors, infection with Epstein-Barr virus is one of the particular factors held accountable for the etiopathogenesis. Human papillomavirus has been associated with cervical, anogenital, and oropharyngeal cancers. The aim of the present study is to demonstrate the presence and incidence of Epstein-Barr virus and human papillomavirus in patients with nasopharyngeal cancer. Methods The information collected for these patients included age at the time of biopsy, gender, alcohol consumption and smoking, and histopathological type of nasopharyngeal cancer. Only patients for whom nasopharyngeal biopsy was performed as punch biopsy were included in the study. In situ hybridization was performed with formalin-fixed, paraffin-embedded tissue sections for Human Papillomavirus and Epstein-Barr virus nucleic acids obtained by means of automated Ventana BenchMark Medical system Results Utilizing in situ hybridization with samples obtained from 56 patients diagnosed with nasopharyngeal cancer. Epstein-Barr virus was positive in 41 out of the 56 (73.2%) patients, while human papillomavirus was positive in 3 (5.4%), and 1 patient (1.8%) had co-infection. Thirty seven (90.2%) of the 41 patients positive for Epstein-Barr virus were Type-2 according to WHO, while 4 (9.8%) were Type-1. All three patients (100%) with Human Papillomavirus positivity were Type-2 according to WHO. Conclusions This study shows the close association between nasopharyngeal cancer and Epstein-Barr virus whereas such an association is not shown for Human Papillomavirus.Öğe Objective acoustic and aerodynamic analyses of voice after frontal anterior laryngectomy with epiglottoplasty(Aves, 2020) Koder, Ahmet; Karasalihoglu, Ahmet Rifat; Adali, Mustafa Kemal; Koten, Muhsin; Uzun, Cem; Yagiz, Recep; Tas, AbdullahObjective: !n this study, we aimed to pe:form an objective analysis of the acoustic and aerodynamic characteristics of vc.lice dunng the pteGpeiative peUod and the ea:ly and late postopetative pr'' r, at110Öğe Possible Ototoxic Effects of Topical Rifamycin Application: An Electrophysiological and Ultrastructural Study(Galenos Yayincilik, 2017) Abayli, Cihan; Kul, Yusuf; Koten, Muhsin; Karasalihoglu, Ahmet Rifat; Tas, Abdullah; Yagiz, Recep; Bulut, ErdoganObjective: This study aimed to investigate possible ototoxicity associated with topical rifamycin application via electrophysiological tests and ultrastructural examinations. Methods: Electrophysiological assessment was performed with tympanometry, auditory brainstem response (ABR), and distortion product otoacoustic emission (DPOAE) measurements. This study was conducted on 40 ears of 20 guinea pigs that were detected to have normal hearing thresholds. The animals were randomly assigned to three groups: Group 1 (n=12) received 0.1 mL rifamycin, Group 2 (n=8) received 0.1 ml gentamycin, and Group 3 (n=20) received 0.1 mL physiological saline. The antibiotics and saline solutions were administered via intratympanic injections. After five injections every other day, electrophysiological tests were performed again on the 15th day. After electrophysiological measurements, the temporal bones of all guinea pigs were prepared for ultrastructural examinations and the cochlear surface morphology was examined by scanning electron microscopy (SEM). Results: The animals in group 3 did not show a statistically significant change in their DPOAE signal/noise ratio (SNR) or ABR thresholds (p>0.05). In groups 1 and 2, the reduction in the DPOAE SNR and the increase in the ABR threshold were statistically significant (p<0.05). Regarding SEM examination results, the animals in groups 1 and 2 showed statistically significant outer hair cell damage and cochlear degeneration due to the ototoxic effect of the drugs (p<0.05), whereas the animals in group 3 showed no significant damage (p>0.05). Conclusion: The results indicate that rifamycin application to the middle ears of guinea pigs has mild ototoxic effects on their inner ears.Öğe The results of tracheotomy in patients with prolonged intubation(Ekin Tibbi Yayincilik Ltd Sti-Ekin Medical Publ, 2008) Tas, Abdullah; Yagiz, Recep; Topcuoglu, Turgay; Kocyigit, Murat; Uzun, Cem; Karasalihoglu, Ahmet RifatObjectives: We evaluated early and late complications of tracheotomy in patients who underwent tracheotomy for prolonged entubation. Patients and Methods: This retrospective study included 227 patients (124 males, 103 females; mean age 47.2 years; range 3 to 85 years) who underwent tracheotomy for prolonged entubation during hospitalization at Reanimation and Intensive Care Unit, Coronary Intensive Care Unit, Cardiovascular Surgery Intensive Care Unit, Neurology Unit, and Chest Diseases Unit. There were 10 children and 217 adult patients. Patients who underwent tracheotomy for upper airway obstruction were excluded. Results: The mean duration of intubation was 10.4 days (range 9 to 13 days). Early complications included hemorrhage (n=15, 6.6%) and subcutaneous emphysema (n=3, 1.3%), and late complications included laryngotracheal stenosis (n=2, 3.2%) and difficult decannulation (n=1, 1.6%). Mortality due to tracheotomy did not occur. Conclusion: Establishing a tracheotomy in patients with prolonged intubation is a reliable surgical procedure with low complication risk, providing a safe ventilatory respiration.
