Yazar "Karakaya, Songul" seçeneğine göre listele

Listeleniyor 1 - 7 / 7
  • Küçük Resim Yok
    Öğe
    Anatomical and Phytochemical Characteristics of Different Parts of Hypericum scabrum L. Extracts, Essential Oils, and Their Antimicrobial Potential
    (Mdpi, 2022) Ergin, Kubra Nalkiran; Karakaya, Songul; Goeger, Gamze; Sytar, Oksana; Demirci, Betul; Duman, Hayri
    Hypericum (Hypericaceae) is a genus that comprises a high number of species around the world. In this study, the roots, aerial parts, flowers, fruits, and aerial parts with flowers from Hypericum scabrum were macerated separately by methanol and water and then fractionated by different solvents of, such as ethyl acetate, n-hexane, butanol, dichloromethane, aqueous residue sub-extracts, and ethnobotanical use. All the extracts, sub-extracts and essential oils of H. scabrum were investigated for the first time in detail for their antimicrobial, total phenolics, and antioxidant activities. Anatomical structures of the root, stem, leaf, upper and lower leaf surface, stamen, sepal, and petal of H. scabrum were examined. The biochemical layout of essential oils was determined by GC and GC/MS. The antioxidant activity was determined by free radical scavenging activity (by DPPH). Antimicrobial activity was applied against Candida albicans ATCC 10231, Escherichia coli ATCC 8739, Staphylococcus aureus ATCC 6538, Bacillus subtilis ATCC 19659, and C. tropicalis ATCC 750 using microdilution methods. The essentials of the aerial parts, flower, and fruit are characterized by the presence of monoterpene hydrocarbons, whereas roots oil include alkanes. The GC-FID and GC-MS analysis showed that major components of roots, aerial parts, flowers, and fruits oils were undecane (66.1%); alpha-pinene (17.5%), gamma-terpinene (17.4%), and alpha-thujene (16.9%); alpha-pinene (55.6%), alpha-thujene (10.9%), and gamma-terpinene (7.7%); alpha-pinene (85.2%), respectively. The aerial part sub-extracts indicated a greater level of total phenolics and antioxidant potential. The n-hexane sub-extracts (from aerial part, flower, and aerial part with flower) showed the best activity against B. subtilis, with 39.06 mu g/mL MIC value. The presented research work indicates that H. scabrum can be a novel promising resource of natural antioxidant and antimicrobial compounds.
  • Küçük Resim Yok
    Öğe
    The anatomical, morphological features, and biological activity of Scilla siberica subsp. armena (Grossh.) Mordak (Asparagaceae)
    (Springer Wien, 2023) Aydin, Bilge; Yuca, Hafize; Karakaya, Songul; Bona, Gulnur Eksi; Goger, Gamze; Tekman, Enes; Sahin, Aydan Acar
    Scilla siberica subsp. armena is known as Siberian Squill which is naturally distributed in Lebanon-Syria, Transcaucasus, and Turkey. It is a perennial bulbous plant with a short vegetation period from March to May. In this study, the antimicrobial, antioxidant, alpha-amylase, and alpha-glucosidase inhibitory activities of corm, leaf, and flower methanolic extracts were examined. The anatomy and morphology of the plant organs were investigated by light and electron microscopes. The anatomy of S. siberica subsp. armena was investigated for the first time by electron microscopy in this study. The corm, leaf, and flower methanolic extracts were assessed against E. coli ATCC 8739, S. aureus ATCC 6538, B. subtilis ATCC 19,659, C. albicans ATCC 10,231, C. krusei ATCC 14,243, and C. tropicalis ATCC 750. Among the extracts, that obtained from the blue pollen showed the best antimicrobial activity against C. tropicalis ATCC 750 strain with a MIC value of 312.5 mu g/mL. The highest phenolic content was determined in leaf extract with 53.59211 mu g GAE/mg extract value. The extract showed the best antilipid peroxidation activity with 376.69 mu g/mL value. Using DPPIT and ABTS(+) tests, it was determined that the flower and leaf extracts have the best activity (IC50 = 756.13 mu g/mL and IC50 = 94.07 mu g/mL, respectively). The flower extract exhibited a-glucosidase inhibitory activity with the IC50 value of 5239 mu g/mL. Based on the presented results of the in vitro antimicrobial, antioxidant, and antidiabetic activities of the S. siberica subsp. armena, we suggest that natural compounds from S. siberica subsp. armena are of potential use for the improvement of an antidiabetic, antioxidant, and antimicrobial agent.
  • Küçük Resim Yok
    Öğe
    Comparison of essential oils and antimicrobial activities of Ferulago mughlae Pesmen (Apiaceae) growing in Turkey
    (Marmara Univ, 2019) Karakaya, Songul; Delimustafaoglu Bostanlik, Fatmagul; Goger, Gamze; Demirci, Betul; Kilic, Ceyda Sibel
    Ferulago species have been utilized dated from ancient times as antihelmentic, carminative, digestive, sedative, aphrodisiac, along with as salads and spice in view of their exclusive odors. F. mughlae Pe.men was investigated for its chemical compositions of essential oils and antimicrobial activity. Antimicrobial activities of essential oils were performed via TLC bioautography methods and essential oils were analysed via GC and GC/MS. alpha-pinene (53.0%), myrcene (3.9%), limonene (6.0%) beta-phellandrene (11.0%) were shown to be as primary components of fruit. Primary components of aerial part were found as alpha-pinene (48.5%), camphene (10.6%), beta-pinene (4.8%) and limonene (3.0%). alpha-pinene (37.3%), camphene (9.1%), limonene (5.3%), terpinolene (3.4%), beta-caryophyllene (3.6%), borneol (9.5%), kessan (8.0%), germacrene B (4.0%), caryophyllene oxide (3.7%) and 2,3,6-trimethylbenzaldehyde (3.7%) were shown to be the primary components of root. Aerial part and fruit essential oils of F. mughlea contain active compounds against Staphylococcus aureus ATCC 6558 while these essential oils did not show any activites against Candida albicans ATCC 90028 and Escherichia coli NRRL B-3008 strains. Root essential oil of F. mughlea did not show any antimicrobial activities against tested all microorganisms. The antimicrobial activities against these microorganisms from this species may be based upon the existence of the primary compounds in the essential oils.
  • Küçük Resim Yok
    Öğe
    Comparison of Essential Oils of Ferulago pachyloba (Fenzl) Boiss., F. trachycarpa Boiss. and F. bracteata Boiss. & Hausskn. Species (Apiaceae) Growing in Turkey and Determination of Their Antimicrobial Activities
    (Taylor & Francis Ltd, 2019) Karakaya, Songul; Simsek, Duygu; Goger, Gamze; Demirci, Betul; Duman, Hayri; Altanlar, Nurten; Kilic, Ceyda Sibel
    Ferulago species have been utilized since ancient times as antihelmentic, digestive, sedative and aphrodisiac, along with in salads or as a seasoning in view of their special odours. F. pachyloba (Fenzl) Boiss., F. trachycarpa Boiss. and F. bracteata Boiss. & Hausskn. species were investigated for their chemical compositions of essential oils and their antimicrobial activities. Antimicrobial activities of essential oils were performed via microbroth-dilution and TLC bioautography methods. GC and GC/MS were utilized to analyse the essential oils. Primary components of aerial parts, flowers, roots and fruits of F. pachyloba were found as, sabinene (16.0 %), (Z)-beta-ocimene (15.1 %); sabinene (25.8 %), (Z)-beta-ocimene (27.5 %); (E)-2-decenal (14.3 %); bicyclogermacrene (11.1 %), respectively. Primary components of aerial parts, roots and fruits of F. trachycarpa were found as, (Z)-beta-ocimene (13.8 %), spathulenol (25.0 %); (E)-2-decenal (11.9 %); spathulenol (32.8 %), bicyclogermacrene (23.0 %). Primary components of aerial parts, flowers and roots of F. bracteata were found as, 7-methoxy-6-(3-methyl-2-butenyl)-coumarin (86.7 %); beta-pinene (12.1 %), beta-phellandrene (22.8 %); (E)-2- decenal (13.9 %), hexadecanoic acid (40.4 %). Essential oils were particularly more effective against Staphylococcus aureus, with MIC values of between 0.39 and 6.25 g/mL, respectively. They did not give significant inhibition against Pseudomonas aeruginosa by TLC bioautography assay. In contrast, they had active components against S. aureus and showed significant inhibition. The antimicrobial activities against these microorganisms from these species may be attributed to the presence of the main components in the essential oils.
  • Küçük Resim Yok
    Öğe
    Comparison of the Essential Oils of Ferula orientalis L., Ferulago sandrasica Pesmen and Quezel, and Hippomarathrum microcarpum Petrov and Their Antimicrobial Activity
    (Turkish Pharmacists Assoc, 2019) Karakaya, Songul; Goger, Gamze; Bostanlik, Fatmagul D.; Demirci, Betul; Duman, Hayri; Kilic, Ceyda Sibel
    Objectives: To determine the chemical composition and antimicrobial activity of the essential oils of the aerial parts of Ferula orientalis L., roots of Ferulago sandrasica Pesmen and Quezel, and aerial parts of Hippomarathrum microcarpum Petrov. Materials and Methods: Essential oils were analyzed by gas chromatography and gas chromatography/mass spectrometry. The antimicrobial activity of the essential oils was determined by bioautography assay. Results: alpha-Pinene (75.9%) and beta-pinene (3.4%) were the major components of the aerial parts of F. orientalis; with limonene (28.9%), beta-pinene (15.6%), and terpinolene (13.9%) for F. sandrasica; and beta-caryophyllene (31.4%) and caryophyllene oxide (23.1%) for the aerial parts of H. microcarpum. Essential oils from the aerial parts of F. orientalis, the roots of F. sandrasica, and the aerial parts of H. microcarpum were active against Staphylococcus aureus and Candida albicans strains. However, essential oils were not active against Pseudomonas aeruginosa or Escherichia coli. Conclusion: The antimicrobial activities against S. aureus and C. albicans of these species may be attributed to the presence of the main components in the essential oils.
  • Küçük Resim Yok
    Öğe
    Investigation on effects of walnut essential oil against glutamate toxicity on cortex neuron and LN405 cancer cell lines, diabetes, and some microorganisms
    (Taylor & Francis Inc, 2023) Yesilyurt, Fatma; Yuca, Hafize; Karakaya, Songul; Tekman, Enes; Demirci, Betul; Taghizadehghalehjoughi, Ali; Goger, Gamze
    In this study, leaf essential oil effects on glutamate toxicity model formed in cortex neurons and LN405 cell cultures were investigated. Antidiabetic activity was evaluated by & alpha;-amylase and & alpha;-glucosidase inhibitions. MIC was used for antimicrobial activity. Seven groups were examined with MTT. Glutamate 10-5 mM in cortex showed 62% viability whereas oil viability did not increase in a dose-dependent manner and the highest viability rate was observed. There are four types of glandular trichomes in leaf anatomy of walnut. The oil exhibited half as much & alpha;-glucosidase inhibitory activity with an IC50 value of 8105 & mu;g/mL, compared to positive control acarbose (IC50 = 4762 & mu;g/mL). MIC of oil was determined to be 625 & mu;g/mL against E. coli, C. albicans, and C. parapsilosis, whereas S. aureus exhibited a MIC of 1250 & mu;g/mL. Major compounds of oil were found as & beta;-pinene (17.6%), & alpha;-pinene (11.3%), & beta;-eudesmol (8.6%), and caryophyllene oxide (6.2%).
  • Küçük Resim Yok
    Öğe
    Screening of antimicrobial, antioxidant, antidiabetic activities, anatomical and morphological properties of Colchicum speciosum Steven (Colchicaceae)
    (Springer Wien, 2022) Karakaya, Songul; Goger, Gamze; Bona, Gulnur Eksi; Yuca, Hafize; Aydin, Bilge; Tekman, Enes; Sahin, Aydan Acar
    Colchicum speciosum Steven species is a perennial stemless plant. C. speciosum is a flowering herb native to mountainous regions of northern Turkey, the Caucasus, and northern Iran. It has been known as Vargit, Aci cigdem, Guz cigdemi. The present study reports the antimicrobial, antioxidant, alpha-amylase and alpha-glucosidase inhibitory activities of corm, leaf and flower methanol extracts, anatomical (light and electron microscopes) properties of root, corm, leaf, flowers and morphological characteristics of C. speciosum. Three different part of extracts C. speciosum were evaluated against E. coli ATCC 8739, S. aureus ATCC 6538, B. subtilis ATCC 19,659, C. albicans ATCC 10,231, C. krusei ATCC 14,243, and C. tropicalis ATCC 750. The most effective extract was found to be MeOH extract for corm and leaf against C. tropicalis ATCC 750 strain with MIC value 160 > mu g/mL. It has been investigated first time anatomy of the tepal, ovary, anther, filament of C. speciosum. Leaf extract was the highest phenolic component (78.61842 mu g GAE/mg extract). As a result of DPPH center dot and ABTS(center dot+) tests, it was determined that the leaf extract showed the best activity (IC50 = 6.568 mu g/mL and IC50 = 3.243 mu g/mL, respectively). Corm extract exhibited alpha-glucosidase inhibitory activity with an IC50 value of 21039 mu g/mL. This is the first study of the in vitro antimicrobial, antioxidant, antidiabetic activities, detailed anatomical and morphological properties of C. speciosum.