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Öğe Effect of Occupational Therapy in Patients Receiving Hemodialysis: A Randomized Controlled Study(Aves, 2021) Inal, Ozgu; Kayihan, Hulya; Karahan, Sevilay; Ustundag, SedatObjective: Hemodialysis (HD) treatment may have negative effects on the occupational performance and quality of life of individuals. This study was planned to investigate the effect of client-centered occupational therapy (OT) intervention on occupational performance and quality of life in individuals receiving HD. Materials and Methods: In total, 42 randomly assigned individuals were divided into control (awareness training) and intervention (awareness training and client-centered OT) groups. The Canadian Occupational Performance Measure was utilized to evaluate the occupational performance, and Kidney Disease Quality of Life Short Form was used to assess the quality of life. Results: Improvement in both occupational performance and quality of life was determined in the intervention group after 8 weeks. In the control group, only the improvement was determined in the general health parameter of quality of life (p<0.05). Conclusion: OT interventions can contribute to improving occupational performance and quality of life of individuals receiving HD treatment, and these interventions can play an important role in the treatment process of these individuals.Öğe geneSurv: An interactive web-based tool for survival analysis in genomics research(Pergamon-Elsevier Science Ltd, 2017) Korkmaz, Selcuk; Goksuluk, Dincer; Zararsiz, Gokmen; Karahan, SevilaySurvival analysis methods are often used in cancer studies. It has been shown that the combination of clinical data with genomics increases the predictive performance of survival analysis methods. But, this leads to a high-dimensional data problem. Fortunately, new methods have been developed in the last decade to overcome this problem. However, there is a strong need for easily accessible, user-friendly and interactive tool to perform survival analysis in the presence of genomics data. We developed an open-source and freely available web-based tool for survival analysis methods that can deal with high-dimensional data. This tool includes classical methods, such as Kaplan-Meier, Cox proportional hazards regression, and advanced methods, such as penalized Cox regression and Random Survival Forests. It also offers an optimal cutoff determination method based on maximizing several test statistics. The tool has a simple and interactive interface, and it can handle high dimensional data through feature selection and ensemble methods. To dichotomize gene expressions, geneSurv can identify optimal cutoff points. Users can upload their microarray, RNA-Seq, chip-Seq, proteomics, metabolomics or clinical data as a nxp dimensional data matrix, where n refers to samples and p refers to genes. This tool is available free at www.biosoft.hacettepe.edu.tr/geneSurv. All source code is available at https://github.com/selcukorkmaz/geneSurv under the GPL-3 license.Öğe AN INVESTIGATION OF FAMILY IMPACT OF CHILDREN WITH CONGENITAL AND ACQUIRED BRAIN INJURY(Turkey Assoc Physiotherapists, 2019) Inal, Ozgu; Karahan, Sevilay; Oksuz, CigdemPurpose: This study aimed to investigate the family impact of children with congenital and acquired brain injury, the levels of depression in mothers, and the factors that might affect family functioning. Methods: This study included 42 children with brain injury (20 congenital, 22 acquired) and their caregiver mothers. Impact on Family Scale (IFS) was used to evaluate family impact and the Beck Depression Inventory for the level of depression in the mothers. The Functional Oral Intake Scale for the status of oral intake of children. Results: This study illustrated that the levels of family impact (z=-1.161, p=0.246) and mothers' depression (z=-0.177, p=0.860) were similar in children with congenital and acquired brain injury. In this study, a relationship was found between the child's feeding position (z=-0.684, p=0.043) and family income level (z=5.981, p=0.046) with family impact. Conclusion: The family impact of having children with disabilities may be related to many factors. In order to understand this mechanism, future studies should be planned with a holistic approach. The results of these studies, provide information to be used in the development of interventions for parents of children with disabilities.Öğe Preformulation of Immediate Release Candesartan Cilexetil Tablets Using Full Factorial Experimental Design(Colegio Farmaceuticos Provincia De Buenos Aires, 2016) Yuce, Meral; Guven, Olgun; Karahan, Sevilay; Saracbasi, Osman; Capan, YilmazThis work aimed compatibility and stability studies, five factor and two level (25) full factorial experimental design of immediate release candesartan cilexetil 32 mg tablets. Candesartan cilexetil is a drug substance, which has low solubility and chemical instability properties. Polyethylene glycol (PEG) 4000 showed stability protective property on candesartan cilexetil in tablets. Structural degradation of candesartan cilexetil was prevented by chemical reactions of terminal hydroxyl groups of PEG 4000 with carboxyl, N-H, N=N and anhydride groups of candesartan cilexetil. Stability protective mechanism was realized by converting crystalline candesartan cilexetil to amorphous form inside the amorphous region of PEG 4000. Stability evaluation showed that candesartan cilexetil could be protected ideally by PEG 4000 concentration of 2.5-10 % (w/w) in tablets. Dissolved drug from tablet could be predicted with high capability from statistical model, resulted from experimental design. Thus, stability and dissolution properties of candesartan cilexetil could be controlled in developed tablets.