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    Comparative Investigation of Anti-Inflammatory Effect of Platelet-Rich Fibrin after Mandibular Wisdom Tooth Surgery: A Randomized Controlled Study
    (Mdpi, 2023) Karaca, Gamze Tanan; Duygu, Gonca; Er, Nilay; Ozgun, Eray
    This study evaluated the anti-inflammatory effect of platelet-rich fibrin (PRF) applied to the extraction socket after impacted mandibular third molar surgery with subjective and objective parameters. Forty-eight patients with impacted wisdom teeth in bilateral and similar positions were included in the study. The control group was formed with the standard surgery and the PRF group was formed with local PRF application in addition to standard procedure (n = 96). The anti-inflammatory activity of PRF on postoperative 2nd and 7th days was evaluated subjectively by clinical parameters and objectively by biochemical parameters. Postoperative 2nd- and 7th-day follow-up data of pain, edema, and trismus in the PRF group were found to be statistically significantly lower. Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were found to be statistically significantly lower in the PRF group than the control in the postoperative 2nd-day follow-up period (p < 0.001). There was no statistically significant difference in interleukin 6 (IL-6) and tumor necrosis factor-alpha (TNF-& alpha;) parameters when the PRF group and the control group were compared in both follow-up periods (p > 0.05). The study has demonstrated the effectiveness of locally applied PRF after ITM surgery via clinical parameters and objective data. The quantitative analysis of CRP and ERS can be an effective parameter in determining the amount of inflammation after ITM surgery.
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    Does Saline Irrigation at Different Temperatures Affect Pain, Edema, and Trismus After Impacted Third Molar Surgery: A Clinical Trial
    (W B Saunders Co-Elsevier Inc, 2023) Canakci, F. Gulfesan; Er, Nilay; Duygu, Gonca; Karaca, Gamze Tanan
    Purpose: Lower impacted third molar surgery is a very common oral-maxillofacial surgical procedure, which has complications such as facial swelling, pain, and trismus. This clinical trial aimed to compare the intensity of postoperative morbidity (pain, facial swelling, and trismus) following the third molar surgery performed using saline irrigation at different temperatures (4 degrees C, 10 degrees C, or 25 degrees C).Materials and Methods: This double-blind, single-center, split-mouth, randomized prospective clinical trial was conducted among 48 systemically and periodontally healthy patients who had bilaterally asymp-tomatic mandibular third molars. Patients were randomly allocated into 2 groups (n = 24) according to the temperature of the saline used. In each patient, one impacted third molar was determined as the test group (4 degrees C or 10 degrees C saline irrigation) and the other impacted third molar as the control group (25 degrees C saline irri-gation). Trismus and swelling were evaluated on the 1st, 3rd, and 7th days postoperatively. Pain perception by visual analog scale (VAS) and the total number of analgesics taken during the 7 postoperative days were recorded. Data were analyzed using the Shapiro-Wilk test, the chi-square test, one-way analysis of variance, Duncan test, the Kruskal-Wallis test, the Dunn test, and the Friedman test (P < .05).Results: Forty-eight patients (28 females, 20 males) with a mean age of 24.6 +/- 3.8 years were included in the study. The duration of operations was similar. VAS values of test groups [test group 1 (4 degrees C): 4.0, test group 1 (10 degrees C): 8.0] and the number of analgesics taken [test group 1 (4 degrees C): 0, test group 1 (10 degrees) C): 3] were significantly lower (P < .001) than control groups (VAS, control group 1: 13.0, control group 2: 15.5, number of analgesic taken, control group 1: 5.5, control group 2: 4.0). Significant differences were found between the test groups in VAS values and the number of analgesics taken (P < .001). Also, the lowest trismus and facial swelling values were detected in the 4 degrees C test group at all time points (P < .001). Conclusion: In the impacted third molar surgery, the use of cooled saline irrigation during bone removal may be a simple, inexpensive, and effective method for reducing early postoperative complaints. (c) 2022 American Association of Oral and Maxillofacial Surgeons
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    Gömülü yirmi yaş dişi cerrahisi sonrası trombositten zengin fibrinin (TZF) antienflamatuar etkinliğinin kıyaslamalı olarak incelenmesi
    (Trakya Üniversitesi, 2021) Karaca, Gamze Tanan; Duygu, Gonca
    Tanan-Karaca G. Gömülü Yirmi Yaş Dişi Cerrahisi Sonrası Trombositten Zengin Fibrinin (TZF) Antienflamatuar Etkinliğinin Kıyaslamalı Olarak İncelenmesi. Trakya Üniversitesi Diş Hekimliği Fakültesi Ağız, Diş ve Çene Cerrahisi Anabilim Dalı Uzmanlık Tezi, Edirne 2021. Bu çalışmanın amacı, benzer pozisyonlu, çift taraflı gömülü alt üçüncü molar diş cerrahisi sonrasında çekim soketine lokal olarak yerleştirilen TZF'nin antienflamatuar etkisinin ağrı, ödem ve trismus gibi klinik parametrelerin subjektif olarak ve ESH, CRP, IL-6 ve TNF ? ? gibi biyokimyasal parametrelerin serum değerlerinin objektif olarak değerlendirilmesidir. Yaşları 19 ile 41 arasında değişen 17 erkek, 31 kadın olmak üzere toplam 48 hasta çalışmamıza dahil edildi. Aynı hastada benzer pozisyonlu, çift taraflı olan 96 adet gömülü alt üçüncü molar dişin standart cerrahi prosedürü ile kontrol grubu, standart cerrahi prosedür sonrası lokal TZF uygulaması ile TZF grubu oluşturuldu. Cerrahi işlem öncesinde, cerrahi işlemden sonra 2. gün ve 7. gün takip dönemlerinde ağrı, ödem ve trismus gibi klinik parametrelerin ve ESH, CRP, IL-6 ve TNF- ? gibi biyokimyasal parametrelerin değerleri ölçülerek kaydedildi. TZF grubundaki ağrı, ödem ve trismus gibi klinik parametrelerin postoperatif 2. gün ve 7. gün takip dönemlerinde, kontrol grubuna göre istatistiksel olarak anlamlı derecede daha düşük olduğu bulundu. Gömülü alt üçüncü molar diş cerrahisi sonrası biyokimyasal parametrelerden ESH ve CRP'nin, postoperatif 2. gün takip döneminde TZF grubunda kontrol grubuna göre istatistiksel olarak anlamlı derecede daha düşük olduğu bulundu (p<0,001). IL-6 ve TNF- ? parametrelerinde TZF grubu ve kontrol grubu karşılaştırıldığında istatistiksel olarak anlamlı bir farkın olmadığı bulundu (p>0,05). 74 Çalışmamıza göre gömülü alt üçüncü molar diş çekimlerinden sonra çekim soketine lokal TZF uygulanmasının ağrı, ödem ve trismusu azaltarak antienflamatuar etkinlik gösterdiği ve bunun biyokimysal verilerle desteklendiği sonucuna varılmıştır.