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Öğe Case of Prolonged Viral Shedding: Chronic, Intermittan COVID-1 9?(Aves, 2022) Kaya, Bilkay Serez; Yilmam, Ilker; Edis, Ebru Cakir; Karabulut, Derya; Mert, Tulin Elmaslar; Eryildiz, Canan; Demir, MuzafferCOVID-19 is a pandemic that has been affecting the entire world and has caused the death of approximately 2.8 million people. Although the duration of viral shedding varies, an average of 7-10 days is accepted. It is still unclear whether prolonged viral shedding means prolonged contagious period and whether COVID-19 will become chronic or not. This article presents a case with hematological malignancy (lymphoma) with the longest polymerase chain reaction positivity that we could find in the literature (110 days in total).Öğe Comparison of Lumbar Disc Herniation and Degeneration Relationship with the Sagittal Morphology of the Spine(Derman Medical Publ, 2015) Delen, Emre; Birgili, Bans; Akinci, Ahmet Tolgay; Karabulut, Derya; Turan, Fatma Nesrin; Kunduracilar, Nebile Muge; Memis, Muzafferin this study, the relationship between the lower intervertebral disc herniation and the degeneration of the spine with the sagittal morphological values were investigated. The data on this study is obtained retrospectively from patients who were operated in our center with the diagnosis of lower level lumbar disc herniation. A total of 117 patients, 75 female and 42 male are included. Patients are divided into two groups as with degeneration (Pfirmann stage III-IV-V) and without degeneration (Pfirmann stage I-II). Among 117 patients, 13 were in the with degeneration group, while 104 were in the without degeneration group. The mean age of the first group was 43.0 (+/- 11.2) years, while the second group had a mean age of 45.3 (+/- 11.4) years and there were not a statistically significant differences between them (P > 0.05). Mean lumbar lordosis angle was 23.30 (+/- 8.92) degree in the first group and 28.81 (+/- 9.17) degree in the without dejeneration group, thus a lower degree was observed in the group with degeneration (P = 0.050). Segmental lordosis angle was 24.69 (+/- 8.91) and 28.17 (+/- 5.75) degree respectively, in the group with degeneration the angle value was lower (P = 0.088). The sacral surface angle in the group with degeneration was 99.51 (+/- 5.36) degree and in the second group it was 100.56 (+/- 6.03) degree. Nevertheless the difference was not statistically significant (P = 0.509). The sacral kyphosis angle is determined as 170.13 (+/- 5.41) degree and 155.59 (+/- 45.96) degree in the two groups respectively and there was statistically significant difference between them (P = 0.059). For cases with lower level lumbar disc herniation there exists a significant relationship between the disc herniation and degeneration, therefore the lumbar lordosis and the segmental lordosis angles are lower in patients with degeneration.Öğe Diffusion tensor imaging: survival analysis prediction in breast cancer patients(Springer Heidelberg, 2024) Urut, Devrim Ulas; Karabulut, Derya; Hereklioglu, Savas; Oezdemir, Gulsah; Cicin, Berkin Anil; Hacioglu, Bekir; Suet, NecetPurpose We aimed to explore the performance of diffusion-tensor imaging (DTI) and apparent diffusion coefficient (ADC) parameters in evaluating disease-free survival (DFS) and overall survival (OS) in patients with invasive breast cancer. Material and methods A total of 49 women with invasive breast cancer who were diagnosed between 2017 and 2022 were included. All patients underwent breast magnetic resonance imaging (MRI) with DTI and diffusion-weighted imaging (DWI) features, with examiners blinded to the clinical data. Volume anisotropy (VA), fractional anisotropy (FA), and ADC values were measured to assess intratumoral measured heterogeneity. Correlations and differences in diffusion metrics according to OS and DFS status of the cases were analyzed. The discriminative ability of the quantitative findings was assessed by receiver operating characteristic (ROC) curve analyses and validated in the independent cohort. Results We evaluated patients with metastases (n = 13, 36.5%) and those without metastases (n = 36, 73.5%). Differences in the ADC, FA, and VA values were observed. The results of Cox regression survival analysis for all the patients included in the survival analysis revealed that DTI metrics contributed to the prediction of overall survival (OS) in the emerging models (p < 0.05). Both FA and VA were associated with OS (p = 0.037 and p = 0.038, respectively). However, ADC was not associated with OS (p = 0.177) or DFS (p = 0.252). Conclusion To the best of our knowledge, this is the first study to assess the prognostic value of DTI-MRI in breast cancer with statistical survival analysis techniques. We believe that DTI measurements can be used as a biomarker for OS analysis in breast cancer given the available data.Öğe EVALUATION OF THE COMPATIBILITY OF ATRIUM AND VENTRICULAR MEASUREMENTS IN THORACIC COMPUTERIZED TOMOGRAPHY AND CORONARY COMPUTERIZED TOMOGRAPHY ANGIOGRAPHY(2020) Ustabaşıoğlu, Fethi Emre; Özgür, Cihan; Karabulut, Derya; Tunçbilek, Nermin; Samancı, CesurAim: We aimed to evaluate the consistency of the measurements of diameter and area of cardiac chambers in coronary computed tomography angiography (CTA) and contrast-enhanced thoracic computed tomography (CT) images.Materials and Methods: 30 patients who underwent thoracic CT and coronary CTA over a 6-month period between August 2016 and August 2019 were included in the study. Maximum left atrium area, anteroposterior and transverse left atrium diameter, right atrium transverse diameter, right and left ventricular transverse diameters were measured by two observers. Inter-observer and intra-observerContrast-enhanced thoracic CT and coronary CTA measurements of the cardiac chambers were found to be perfectly compatible. Both left atrial axial area and AP diameter were evaluated on coronary CTA images and contrast-enhanced thoracic CT with excellent reproducibility.Conclusion: To our knowledge, this is the first study that shows the measurement of diameter and area of the cardiac chambers in thoracic CT and coronary CTA and comparing them with each other. Thoracic CT, with its high reproducibility, could be a useful tool in evaluation of cardiac chambers.Öğe A Giant Lipoma Presenting with Colocolonic Invagination(2018) Karabulut, Derya; Kula, Osman; Usta, Ufuk; Sezer, Atakan; Tunçbilek, NerminColonic lipomas are very rare and usually do notcause symptoms until they reach large size. Giantlipomas may mimic malignancy, depending on theirsymptoms, such as obstruction and invagination.Colonic lipomas should always be considered indifferential diagnosis and proper radiological,colonoscopic evaluation is important to avoideunnecessary extensive surgical resection.Öğe Giant Pulmonary Herniation: A Late and Rare Complication of Minimally Invasive Lung Biopsy for Interstitial Lung Disease(Marmara Univ, Inst Health Sciences, 2023) Edis, Ebru cakir; Yanik, Fazli; Karabulut, Derya; Hereklioglu, SavasPulmonary herniation is the protrusion of the lung parenchyma beyond the normal limits of the thoracic cavity. It is a rare entity. In general, the defect in the chest wall is accompanied by increased intrathoracic pressures in the formation mechanism. Usually the cause is blunt-penetrating thoracic trauma, violent cough or previous thoracic surgery with insufficient closure of the chest wall. We report a case with giant pulmonary herniation that developed four years after biopsy in a patient diagnosed with usual interstitial pneumonia by VATS. Although this is a very rare condition in the literature, one of the late and rare complications of diagnostic pulmonary resections with awake VATS may be caused giant pulmonary herniationÖğe PET/CT for Early Detection of COVID-19 Pneumonia: Diffuse Fluorodeoxyglucose Uptake in the Lungs without any Additional Changes in a Patient with Breast Cancer(Galenos Yayincilik, 2021) Ozdemir, Busra; Gunay, Burak; Karabulut, Derya; Altun, Gulay DurmusCoronavirus disease-2019 (COVID-19), which causes infections in the upper and lower respiratory tract, became a pandemic shortly after it was first diagnosed in Wuhan city, China. Many people are affected with high mortality rates and severe respiratory distress syndrome. During this pandemic, all physicians paid attention to the findings of COVID-19. Suggestive findings in (18)fluorine-fluorodeoxyglucose (F-18-FDG) positron emission tomography/computed tomography (PET/CT) were characterized as increased F-18-FDG uptake in bilateral peripheral consolidative areas and ground glass opacities. We aimed to show diffuse FDG uptake in PET images with indefinable lesions in CT as a suspicious finding for early COVID-19.Öğe Renal leiomyoma: An uncommon differential diagnosis of renal masses in pediatric age(Elsevier Science Inc, 2021) Karabulut, Derya; Alkan, Aykut; Ozgur, Cihan; Gunay, Burak; Burgazdere, Gulsah; Puyan, Fulya OzLeiomyoma is a mesenchymal tumor which arise from any structure or organ containing smooth muscle, but is frequently seen in the female genital tract. Renal leiomyoma is extremely rare benign lesion with low incidence (1:1000), has been reported mostly in adults and very few cases have been described in the pediatric age-group. It is often asymptomatic and can be diagnosed when reaches large sizes. Hereby, we present a case of renal leiomyoma in a smaller size, in the pediatric age group.Öğe Skeletal muscle loss during anti-epidermal growth factor receptor therapy is an independent prognostic factor on non-small cell lung cancer patients survival(Imprimatur Publications, 2021) Kucukarda, Ahmet; Gokyer, Ali; Gokmen, Ivo; Hacioglu, Muhammed Bekir; Kostek, Osman; Kurt, Nazmi; Karabulut, DeryaPurpose: We aimed to assess whether skeletal muscle loss during EGFR thyrosine kinase inhibitor therapy of advance non-small cell lung cancer patients is an independent prognostic factor for progression-free survival (PFS) and overal survival (OS). Methods: A total of 45 patients who had computed tomography images were retrospectively evaluated at the diagnosis and during the treatment period before progression occurs. Results: During treatment 19 patients (42.2%) had skeletal muscle loss. Objective response rates in muscle loss group and muscle stable group were 36.8% and 73.0%, respectively (p<0.01). Median follow-up time was 18.9 months (14.832.1). Median PFS was 14.7 months (95% CI 12.1-17.3) in muscle stable group and 7.6 months (95% CI 6.7-8.5) in muscle loss group (p<0.01). Median OS was 18.3 months (95% CI 16.5-20.2) in muscle loss group while it was 30.1 months (95% CI 22.1-38.2) in muscle stable group (p<0.01). In multivariate analysis for both PFS and OS, skeletal muscle loss was an independent prognostic factor. Hazard ratios (HR) for PFS and OS were 12.2 (95% CI 4.3-34.4) and 3.51 (95% CI 1.41-8.73) respectively. Conclusion: On CT imaging skeletal muscle loss before progression is an independent prognostic factor for both PFS and OS in advance non-small cell lung cancer patients who received EGFR tyrosine kinase inhibitor therapy.Öğe Ultrasound evaluation of stiffness and vascularity of renal parenchymal damage secondary to hydronephrosis in pediatric patients using shear wave elastography and superb microvascular imaging(Wiley, 2024) Gunay, Burak; Solak, Serdar; Ustabasioglu, Fethi Emre; Kula, Osman; Karabulut, Derya; Tuncbilek, NerminAims: The purpose of this study is to assess the diagnostic value of SWE (shear wave elastography) and renal parenchymal elasticity and microvascularization with the SMI (super microvascular imaging) technique in diagnosing and predicting the progression of renal parenchymal damage in pediatric patients with hydronephrosis. Patients and Methods: A total of 45 patients were included in the prospective study. To evaluate parenchymal changes, SWE and SMI-Vacularity Index (VI) measurements were performed in various sections of the affected and normal kidneys. The affected and control renal pelvises' anteroposterior (AP) diameters were also measured. Results: The average SWE values were measured as 16.62 kPa for the affected kidneys, whereas the control kidneys showed an average SWE value of 12.70 kPa, indicating a statistically significant difference (p < .01). Furthermore, in the affected kidneys, the average SMI-VI value was measured as 5.92, whereas the control kidneys exhibited a higher average SMI-VI value of 6.64, showing a statistically significant difference (p < .01). A reverse correlation was found between renal pelvis AP diameter and SMI-VI values, while a positive correlation existed between renal pelvis AP diameter and SWE values. Conclusions: We believe that SWE and SMI may be useful for diagnosing and predicting the progression of renal parenchymal damage in pediatric hydronephrotic patients.
