Yazar "Kaplan, M." seçeneğine göre listele
Listeleniyor 1 - 5 / 5
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Mesanenin değişici epitel hücreli kanseri tanısında nükleer matriks protein 22 (NMP22)'nin yeri(2001) Alagöl, B.; Kaplan, M.; İnci, O.; Ersoy, E.; Atakan, İ. H.; Kaya, E.Mesane kanseri sıklığı ve yüksek oranda nüks göstermesi, tanı ve takipte güvenilirliği yüksek, erken sonuç veren noninvaziv yeni teşhis metotlarının geliştirilmesini zorunlu kılmaktadır. Çalışmamızda Nükleer matriks protein 22 (NMP22) ve idrar sitolojisini mesane kanserlerinin tanısındaki değeri araştırıldı. Çalışmamızda mesane değişici epitel hücreli karsinomu (DEHK) olan 43 olguluk bir grup (37 erkek ve 6 kadın, ortalama yaş 61,27) ve 37 kişilik kontrol grubu (27 erkek ve 10 kadın, ortalama yaş 54.35) ele alındı. NMP22 test sonuçları idrar sitolojisi ile duyarlılık, özgüllük, pozitif ve negatif kestirim değerleri ve toplam tanı değerine göre karşılaştırıldı. NMP22 Test ELISA NMP22 (Matritech) tekniğine göre yapıldı. Bu test kanser hücreleri tarafından salınan nükleer mitotik proteinleri ölçer. NMP22 testinin sınır değeri 10.0 U/ml olarak alındı. Ortalama NMP22 değeri tümörlü hastalarda 48.38, kontrol grubunda ise 6.23 bulundu. Tümörlü 43 olgunun 35'i yüzeyel (pTa, pT1), 8'i invaziv tümörlüydü. Ortalama NMP22 değerleri yüzeyel mesane tümörlü hastalarda 31.88, invaziv tümörlülerde ise 120.5 idi. NMP22 testinin duyarlılığı %86, özgüllüğü %75.6, idrar sitolojisinde ise bu değerler %46.5 ve %94.5 bulundu. Mesane DEHK'larının tanısında NMP22 testinin duyarlılığı, negatif kestirim değeri ve toplam tanı değeri idrar sitolojisinden anlamlı derecede daha iyi olmasına rağmen, özgüllüğü ve pozitif kestirim değeri daha azdır.Öğe 'Multimodal' approach to management of prostate biopsy pain and effects on sexual function: efficacy of levobupivacaine adjuvant to diclofenac sodium - a prospective randomized trial(Wiley-Blackwell Publishing, Inc, 2010) Aktoz, T.; Kaplan, M.; Turan, U.; Memis, D.; Atakan, I. H.; Inci, O.P>We assessed the analgesic efficacy of levobupivacaine when administered as an adjuvant to diclofenac sodium in prostate biopsy pain management and effects of prostate biopsy on sexual function. Ninety patients underwent transrectal ultrasound (TRUS)-guided biopsy of the prostate and were randomly assigned to three groups: group D received diclofenac sodium suppository; Group L received periprostatic injection of levobupivacaine; group DL received diclofenac suppository and levobupivacaine in addition. Patients were asked to use a visual analogue scale score (VAS) questionnaire about pain after 10 core prostate biopsy. Sixty-two patients reported to be prostate cancer-free underwent further evaluation with the International Index of Erectile Function-5 (IIEF-5) questionnaire at 1 and 3 months after biopsy. Mean pain scores during prostate biopsy were significantly lower in group DL and were superior to the group L and group D (P < 0.001). Mean IIEF-5 score prior to biopsies was significantly higher when compared with the mean IIEF-5 score 1 month after biopsy (P < 0.0001). Mean IIEF-5 scores 1 month after biopsy were significantly lower when compared with the mean IIEF-5 scores 3 months after biopsy (P = 0.002). TRUS-guided prostate biopsies have a statistically significant impact on short-term erectile function, but this difference is not clinically significant; however, medium-term erectile function is not affected both statistically and clinically.Öğe Penile and scrotal involvement in Buerger's disease(Wiley-Blackwell Publishing, Inc, 2008) Aktoz, T.; Kaplan, M.; Yalcin, O.; Atakan, I. H.; Inci, O.Buerger's disease (thromboangiitis obliterans) is a recurrent inflammatory, nonatherosclerotic vasoocclusive disease, which typically affects small and medium-sized arteries, veins and nerves of the upper and lower extremities. Although the exact underlying causes of Buerger's disease are still unknown, the disease is strongly associated with tobacco smoking. Affected patients are mostly young male smokers who develop ulcers and gangrene of the toes and fingers as a result of vascular ischaemia. We report a 47-year-old man with scrotal and penile necrosis. Partial penectomy, scrotal debridement and urethra-cutaneous anastomosis were performed.Öğe Prognostic factors for renal cell carcinoma: Trakya University experience from Turkey(Wiley, 2010) Yurut-Caloglu, V.; Caloglu, M.; Kaplan, M.; Oz-Puyan, F.; Karagol, H.; Ibis, K.; Cosar-Alas, R.The purpose of the present study is to evaluate the prognostic factors of patients with renal cell carcinoma. The treatment results such as distant metastasis-free survival and overall survival of 59 previously untreated patients were retrospectively analysed. Median follow-up was 17.5 months (3.8-88.5 months). Overall survival was 22.4 months (3-87 months). Distant metastasis developed in 35 (59%) patients. The Eastern Cooperative Oncology Group (ECOG) performance status (P = 0.022), tumour size (P = 0.025) and lymphatic invasion (P < 0.0001) were significantly effective prognostic factors for distant metastasis-free survival on multivariate analysis. Related to overall survival, gender (P = 0.025), ECOG performance status (P = 0.027), nuclear grade (P = 0.002), tumour size (P = 0.029), T stage (P = 0.044), nodal involvement (P = 0.003), surgical margin (P = 0.046), renal sinus invasion (P < 0.0001), perineural growth (P = 0.001) and lymphatic invasion (P < 0.0001) were significant prognostic factors on univariate analysis. Gender (P = 0.008), ECOG performance status (P = 0.027), tumour size (P = 0.025) and lymphatic invasion (P < 0.0001) retained their significance on multivariate analysis. We concluded that the most important prognostic factors for patients with renal cell carcinomas are ECOG performance status, tumour size and lymphatic invasion.Öğe Radiographic size versus surgical size of renal masses: Which is the true size of the tumor?(Imprimatur Publications, 2009) Alicioglu, B.; Kaplan, M.; Yurut-Caloglu, V.; Usta, U.; Levent, S.Purpose: The size of a renal neoplasm is important for staging, prognosis and selection of appropriate treatment. Our aim was to determine whether there is a discrepancy between the radiographic and pathological size of renal tumors. Patients and methods: The maximum size of 35 resected renal tumors was measured by computed tomography (CT) by 2 independent observers. The radiographic and pathological sizes were compared by size range and tumor radiological features. Results: Although the radiographic and pathological size for all tumors vas not statistically different (7.50 is. 6.25 cm, p=0.452), the average radiographic size was larger than pathological tumor size in tumors smaller than 7 cm. Solid tumors showed more reduction in size (17.02%) compared with cystic and necrotic tumors (p=0.731). Only the radiographic size of ill-defined tumors was smaller than their pathological size (average 33.33%; p=0.865). The influence of tumor side (left or right kidney) and its location within the kidney did not influence the degree of decrease (p=0.147 and p=0.981, respectively). Conclusion: A reduction in the size of renal tumors is observed in tumors < 7 cm, which is explained by, vasoconstriction during the temporary renal artery occlusion, sulfate hypothermia and blood loss during the operation. This reduction of size is secondary to surgery, the radiographic size of renal minors should be considered in staging and selecting the appropriate treatment for tumors < 7 cm for which the decision of surgical approach depends on the size of the tumor.
