Yazar "Kandulu, Huseyin" seçeneğine göre listele
Listeleniyor 1 - 4 / 4
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Chitosan Effectiveness in End-to-End Vascular Anastomosis with Minimal Suture Technique(Springer India, 2023) Kandulu, Huseyin; Top, HusamettinBackground Vascular anastomosis, which is usually performed during complex surgical procedures such as transplantation and reconstruction, is a time-consuming and skilled practice. The aim of this study is to compare the vascular anastomosis technique made with minimal suture and chitosan with the traditional technique. Methods Twenty adult female Wistar Albino rats were randomly divided into two groups, the control group (n = 10) in which the traditional hand-sewn technique was applied and the chitosan group (n = 10) with the minimal suture technique. The duration of anastomosis, patency rates on the first and 28th days, and histopathology of the vessels on the 28th day were evaluated. Results The mean duration of anastomosis was calculated as 19.18 +/- 1.79 min in the control group and 11.30 +/- 0.97 min in the chitosan group. The difference between the two groups was statistically significant (p < 0.001). There was no significant difference between the patency rates of the control and chitosan groups, both within group (between the 1st and 28th days) and between the groups by day. In histopathological examination, especially in the control group, transmural damage, foreign body reactions due to the suture material, and granulomas were observed around the suture, while perivascular foreign body reactions were observed less frequently in the chitosan group compared to the control group. Conclusion We have shown that this new method of microvascular anastomosis is effective, easy to learn, and requires less time than conventional sutures. However, other studies should be conducted to prove the feasibility of this new technique and to prove its long-term success and results in the vessels.Öğe Effect of Lidocaine on Reducing Injury in a Rat Electrical Burn Model(Lippincott Williams & Wilkins, 2012) Benlier, Erol; Eskiocak, Sevgi; Puyan, Fulya Oz; Sikar, Emel Yurdakul; Kandulu, Huseyin; Omurlu, Imran Kurt; Top, HusamettinElectrical injuries induce progressive tissue loss. We evaluated the effect of lidocaine on tissue necrosis after electrical burn injuries. Forty-two male Wistar albino rats (250-300 g) were divided into 3 groups [Group A (n = 6), control group without an electrical burn injury; and Groups B (n = 18) and C (n = 18), electrical burn injury groups without and with lidocaine therapy, respectively]. Three separate analyses were performed at different time points on 6 of 18 rats from Groups B and C at each time point. Electrical burns were induced by applying 220 V AC between the left upper and right lower extremities for 10 seconds. Myeloperoxidase and malondialdehyde levels were measured in skin and muscle biopsy specimens after the first hour, fresh and dry weight differences in the amputated extremities were calculated after 24 hours, and live and necrotic tissue areas were measured at 7 days after burn injury. We found that lidocaine reduced edema, the number of neutrophils, and neutrophil damage in tissues. We conclude that lidocaine decreased the amount of necrotic tissue caused by electric injury.Öğe Fucoidin, a neutrophil rolling inhibitor, reduces damage in a rat electrical burn injury model(Elsevier Sci Ltd, 2011) Benlier, Erol; Eskiocak, Sevgi; Puyan, Fulya Oz; Kandulu, Huseyin; Unal, Yasin; Top, Husamettin; Aygit, Ahmet CemalBackground: Electrical injuries induce progressive tissue loss caused by free oxygen radicals released from neutrophil aggregates. Fucoidin, a potent inhibitor of L-selectin function, reduces the aggregation of neutrophils. The aim of this study was to evaluate the effect of fucoidin on tissue damage in rat electrical burn injury model. Methods: Forty-two male Wistar albino rats (250-300 g) were divided into 3 groups (Group A (n = 6), control group without electrical burn injury; Groups B (n = 18) and C (n = 18), electrical burn injury groups without and with fucoidin therapy, respectively). Three separate analyses were performed at different time points on 6 out of 18 mice from Group B and C at each time point. Biochemistry (myeloperoxidase and malondialdehyde levels) and histopathology (number of neutrophils) of the skin and muscle biopsies at 1st hour; tissue edema (ratio of wet weight/dry weight of extremities) at 24th hour; and necrotic areas at 7th day after electrical injury were evaluated. The electrical burn was induced by exposing rats to 220 V AC between their left upper extremity and right lower extremity for 10 s. Fucoidin was administered as 25 mg/kg intravenous bolus injection at 15 mm after electrical burn injury. Results: Myeloperoxidase and malondialdehyde levels, number of neutrophils, tissue edema, and necrotic area were significantly less in fucoidin-applied rats than the group without fucoidin therapy. Conclusions: Fucoidin inhibits tissue damage induced by electrical burn injury in rats by reducing necrotic area, edema and number of neutrophils. (C) 2011 Elsevier Ltd and ISBI. All rights reserved.Öğe Isolated uveitis: A rare complication of electrical injury(Lippincott Williams & Wilkins, 2008) Benlier, Erol; Top, Husamettin; Kandulu, Huseyin; Yurdakul, Emel[Abstract Not Available]