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    In vitro effects of amiodarone on coronary artery bypass grafts
    (Baycinar Medical Publ-Baycinar Tibbi Yayincilik, 2015) Karaca, Okay Guven; Ege, Turan; Canbaz, Suat; Gur, Ozcan; Karadag, Cetin Hakan; Ecevit, Ata Niyazi; Kalender, Mehmet
    Background: This study aims to investigate the effects of amiodarone on the most commonly used grafts, internal thoracic artery (ITA), saphenous vein (SV), and radial artery (RA) in organ bath. Methods: Twenty patients (16 males, 4 females; mean ages 58.4 +/- 9.9 years; range 38 to 80 years) who underwent isolated coronary artery bypass graft (CABG) surgery between May 2008 and October 2008 were included in this study. Internal thoracic artery, saphenous vein, and radial artery grafts were harvested. Specimens were taken to laboratory in +4 degrees C Krebs solution. Specimens were suspended in 10 ml organ bath containing Krebs solution. Results: Amiodarone caused relaxation in all grafts (ITA, RA, SV) between 10(-9)-10(-3,5) M concentration in a dose dependent manner (p<0.01). Maximum relaxation rates (mean) induced by amiodarone were 78.9%, 74.9% and 66.5% for ITA, RA and SV, respectively. Conclusion: Although we did not evaluate the endothelium-independent relaxation response in this study, higher rates of relaxation response were observed with ITA grafts comparing to other grafts, and these results were compatible with literature. According to the results of this study, amiodarone-class III antiarrhythmic agent- caused vasodilation in all three grafts in vitro. Vasodilator effect of amiodarone on grafts may help to increase patency rates.
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    Retroperitoneal Tunneled Hemodialysis Catheter in Inferior Vena Cava: A Report of Three Cases
    (Galenos Yayincilik, 2019) Karaca, Okay; Ecevit, Ata; Kalender, Mehmet; Tasar, Mehmet; Ege, Turan
    Finding an appropriate vascular access is difficult in long term hemodialysis patients for emergency hemodialysis. The aim of this study was to present tunneled hemodialysis catheter placement to inferior vena cava through retroperitoneal approach as an alternative method for patients who have emergency hemodialysis and no other choice. We placed tunneled hemodialysis catheter into inferior vena cava through retroperitoneal approach in three patients for emergency hemodialysis, two of them being female and one being male. The mean age of the patients was 51.3 years (min: 36, max: 56) and mean dialysis time was for a period of 4.3 years (min: 2, max: 6). In conclusion, placement of tunneled hemodialysis catheter into the inferior vena cava through retroperitoneal approach can be an alternative vascular access procedure for patients especially who have emergency hemodialysis and no other choice.