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Öğe Blunt chest trauma in childhood(Wiley, 2007) Inan, Mustafa; Ayvaz, Suleyman; Sut, Necdet; Aksu, Burhan; Basaran, Umit N.; Ceylan, TuranBackground: Although thoracic injuries are uncommon in children, their rate of morbidity and mortality is high. The aim of this study was to evaluate the clinical features of children with blunt chest injury and to investigate the predictive accuracy of their paediatric trauma scores (PTS). Methods: Between September 1996 and September 2006, children with blunt thoracic trauma were evaluated retrospectively. Clinical features and PTS of the patients were recorded. Results: There were 27 male and 17 female patients. The mean age was 7.1 +/- 3.4 years, and the mean PTS was 7.6 +/- 2.4. Nineteen cases were injuries caused by motor vehicle/pedestrian accidents, 11 motor vehicle accidents, 8 falls and 6 motor vehicle/bicycle or motorbike accidents. The following were noted: 28 pulmonary contusions, 12 pneumothoraxes, 10 haemothoraxes, 9 rib fractures, 7 haemopneumothoraxes, 5 clavicle fractures and 2 flail chests, 1 diaphragmatic rupture and 1 pneumatocele case. The cut-off value of PTS to discriminate mortality was found to be <= 4, at which point sensitivity was 75.0% and specificity was 92.5%. Twenty-seven patients were treated non-operatively, 17 were treated with a tube thoracostomy and two were treated with a thoracotomy. Four patients who suffered head and abdominal injuries died (9.09%). Conclusion: Thoracic injuries in children expose a high mortality rate as a consequence of head or abdominal injuries. PTS may be helpful to identify mortality in children with blunt chest trauma. Blunt thoracic injuries in children can be treated with a non-operative approach and a tube thoracostomy.Öğe Can Pediatric Surgeons Become Truly Experienced for Thyroid Surgery on a Universal Scale?(Galenos Yayincilik, 2018) Inanc, Irem; Sezer, Atakan; Inan, Mustafa[Abstract Not Available]Öğe Clinical features of congenital neck masses in children(Aves Yayincilik, Ibrahim Kara, 2007) Inan, Mustafa; Yagiz, Recep; Tas, Abdullah; Ayvaz, Sueleyman; Ada, ServetObjectives: Diagnostic approaches and treatment methods in children with a congenital neck mass were evaluated. Patients and Methods: A total of 36 patients (20 girls, 16 males; mean age 8.6 +/- 5.9; range 1 month to 15 years) treated in our hospital for congenital neck mass between 1996 and 2003, were retrospectively analysed. Results: Thirteen cases were diagnosed as dermoid cyst, 7 as branchial cyst, 7 as thyroglossal duct cyst (TDC), 5 as torticollis, 4 as cystic hygroma and 1 as lipoblastorna. In all 7 of the cases with TDC, the mass presented with a cutaneus fistula. Two of the branchial cysts were localized on the right and the rest on the left side. One of the cases with dermoid cyst exhibited a lateral localization. Ultrasonography, computed tomography and thyroid syntigraphy were used for diagnostic purposes. Three patients with torticollis received physical therapy while the remaining patients were surgically treated. The preliminary diagnosis was incorrect in four cases and their histopathological diagnosis was dermoid cyst. Conclusion: Congenital neck masses in children are usually benign. Due to their similar clinical features, dermoid cysts can be confused with TDC and branchial cysts.Öğe Colon perforation due to pathologic aerophagia in an intellectually disabled child(Blackwell Publishing, 2007) Basaran, Umit N.; Inan, Mustafa; Aksu, Burhan; Ceylan, TuranAerophagia, characterized by symptoms related to repetitive swallowing of air, is a functional gastrointestinal disorder. In some cases, severe aerophagia causes massive bowel distention and leads to volvulus, ileus, and even intestinal necrosis and perforation. A 10-year-old intellectually disabled boy was referred to our unit due to severe abdominal distention, bilious vomiting, no passage of feces and flatus during the previous 3 days. He had experienced episodes of severe abdominal distention and flatulence over the past 2-3 years. In the exploratory laparotomy, two old colonic perforations were found. Splenic flexura resection and diverting colostomy were performed. Rectal biopsy showed ganglionic architecture. During the fifth postoperative month, he was admitted to the emergency unit with severe abdominal distention. During this visit, we observed him swallowing air. For this reason, his primary illness was diagnosed as a pathologic aerophagia. The colostomy was closed 11 months following the first operation. His parents did not accept gastrostomy as a desufflator. For this reason, they were taught nasogastric tube installation for gastric distention. Briefly, if abdominal distention increases during the course of the day and increased flatus is observed during sleep, aerophagia could be the primary pathology. If aerophagia could cause complications, gastrostomy should be applied. If the parents refuse gastrostomy, the parents could perform nasogastric tube drainage.Öğe Complicated xanthogranulomatous pyelonephritis in a child(Wiley-Blackwell Publishing, Inc, 2010) Ozkayin, Nese; Inan, Mustafa; Aladag, Nukhet; Kaya, Meryem; Iscan, Burcin; Yalcin, Omer[Abstract Not Available]Öğe Congenital Spigelian hernia associated with undescended testis(Zhejiang Univ Sch Medicine, 2012) Inan, Mustafa; Basaran, Umit Nusret; Aksu, Burhan; Dortdogan, Zafer; Dereli, MuratBackground: A Spigelian hernia (SH) is a ventral interstitial hernia through, a defect in the Spigelian fascia; an undescended testis is sometimes associated with this clinical entity in male newborns. The etiopathogenesis, surgical anatomy, diagnostic methods, and treatment for this rare condition are discussed with a review of the literature. Methods: A 20-day-old newborn was admitted to our hospital for a swelling in the right lower abdomen and undescended testis. Physical examination of the abdomen and scrotum revealed a congenital SH associated with cryptorchidism. Results: Herniotomy, herniorrhaphy, and orchidopexy were performed. In the post-operative period, scrotal abscess occurred and was drained. After drainage, the fixed testis was found to be atrophic. Conclusions: This association may be a distinct clinical syndrome. The operation time in cases of neonatal SH with undescended testis should be well planned because of probable surgical complications such as vascular damage, tension, or compression. World J Pediatr 2012;8(2):185-187Öğe Desferrioxamine effectively attenuates testicular tissue at the end of 3 h of ischemia but not in an equal period of reperfusion(Elsevier Sci Ltd, 2014) Ayvaz, Suleyman; Inan, Mustafa; Aksu, Burhan; Karaca, Turan; Cemek, Mustafa; Ayaz, Ahmet; Basaran, Umit NusretObjective: To investigate the effect of desferrioxamine (DFX) on ipsilateral and contralateral testis damage caused by experimental testis torsion and detorsion. Materials and methods: Forty rats were divided into five groups (n = 8): control, torsion (T), torsion + desferrioxamine (T + DFX), torsion/detorsion (T/D), and torsion/detorsion + desferrioxamine (T/D + DFX). The right testes of the rats were subjected to torsion and detorsion for 3 h each. Thirty minutes before the application of torsion and detorsion, DFX (100 mg/kg) was administered intramuscularly. Blood samples and testicular tissues were examined using specific biochemical and histopathological methods. Results: Ipsilateral and contralateral testis tissue glutathione levels in the T group decreased compared with the control and T + DFX groups. Plasma glutathione peroxidase activity in the T, T/D, and T/D + DFX groups was lower than in the control group. Plasma catalase activity in the T and T/D groups decreased compared with the control group. Ipsilateral mean seminiferous tubule diameter of the T group was lower than that of the T + DFX group. The ipsilateral mean testis biopsy scores in the T and T/D groups were lower than in the control group. Conclusion: The administration of DFX prior to torsion may be useful only for preventing ischemic damage in ipsilateral and contralateral testes. (C) 2013 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.Öğe Desferrioxamine Reduces Oxidative Stress in the Lung Contusion(Hindawi Ltd, 2013) Basaran, Umit Nusret; Ayvaz, Suleyman; Aksu, Burhan; Karaca, Turan; Cemek, Mustafa; Karaboga, Ihsan; Inan, MustafaOur hypothesis in this study is that desferrioxamine (DFX) has therapeutic effects on experimental lung contusions in rats. The rats were divided into four groups (n = 8): control, control+DFX, contusion, and contusion+DFX. In the control+DFX and contusion+DFX groups, 100 mg/kg DFX was given intraperitoneally once a day just after the contusion and the day after the contusion. Contusions led to a meaningful rise in the malondialdehyde (MDA) level in lung tissue. MDA levels in the contusion+DFX group experienced a significant decline. Glutathione levels were significantly lower in the contusion group than in the control group and significantly higher in the contusion+DFX group. Glutathione peroxidase (GPx) and superoxide dismutase (SOD) levels in the contusion group were significantly lower than those in the control group. In the contusion+DFX group, SOD and GPx levels were significantly higher than those in the contusion group. In light microscopic evaluation, the contusion and contusion+DFX groups showed edema, hemorrhage, alveolar destruction, and leukocyte infiltration. However, histological scoring of the contusion+DFX group was significantly more positive than that of the contusion group. The iNOS staining in the contusion group was significantly more intensive than that in all other groups. DFX reduced iNOS staining significantly in comparison to the contusion group. This study showed that DFX reduced oxidative stress in lung contusions in rats and histopathologically ensured the recovery of the lung tissue.Öğe Dietary Intakes of Adolescents Living in Edirne, Turkey(Routledge Journals, Taylor & Francis Ltd, 2008) Garipagaoglu, Muazzez; Oner, Naci; Vatansever, Ulfet; Inan, Mustafa; Kucukugurluoglu, Yasemin; Turan, CagriObjective: To assess the dietary intakes of the adolescents in the area of Edirne, Turkey. Design: Cross-sectional, prospective, epidemiological study. Settings and Subjects: Our study group consists of 1944 adolescents aged between 12 to 17 years; 940 females and 1004 males. Interventions: Three-day self-reported food records were collected from the subjects and evaluated by a nutrient database pro.-ram. Reported nutrient intake data were analyzed for gender differences. Minitab statistical program was used to compare nutritional data of subjects. Results: Energy, calcium, magnesium, folic acid, vitamins A, E, thiamine. and fiber intakes of whole adolescents, and also iron intakes of female adolescents were most likely to be inadequate compared with the recommendations. Iron, calcium, folic acid, thiamine, and fiber intakes were below two thirds of RDA/DRI in a large proportion of the adolescents. The intakes of protein, riboflavin, vitamin C, phosphorus and zinc were found to be adequate in a large percentage of the subjects. Forty eight percent of females and 60.1 % of males were below 2/3 of the RDA for energy. Conclusion: Pediatricians and dietitians should train the adolescents living in our region and our country on practical strategies for making healthy food choices rich in nutrient content relative to energy value to ensure intakes that approach the recommendations.Öğe Educational Perspective of the Balkan Medical Journal(Galenos Publ House, 2013) Inan, Mustafa[Abstract Not Available]Öğe Effect of curcumin on ipsilateral and contralateral testes after unilateral testicular torsion in a rat model(Karger, 2008) Basaran, Umit Nusret; Dokmeci, Dikmen; Yalcin, Omer; Inan, Mustafa; Kanter, Mehmet; Aydogdu, Nurettin; Turan, NesrinObjective: The aim of the study was to determine the protective effect of curcumin on testicular ischemia- reperfusion ( I/ R) injury. Materials and Methods: 32 male rats were divided into four groups ( n = 8): group 1: control; group 2: ischemia; group 3: I/ R, and group 4: I/ R+CUR. Curcumin ( 150 mg/ kg, p. o.) was administered before 30 min of reperfusion in group 4. Malondialdehyde ( MDA) levels, Johnsen's testicular biopsy scores, and mean seminiferous tubule diameter measurements were evaluated in testes. In addition, endothelial nitric oxide synthase ( eNOS) and inducible nitric oxide synthase ( iNOS) expressions were evaluated immunohistochemically. Results: MDA levels in control groups were significantly lower than other groups in ipsilateral and contralateral testes. Johnsen's scores in the control group were significantly higher than in other groups. MDA levels and Johnsen's scores in the I/ R+ CUR group were similar to the ischemia and I/ R groups in ipsilateral and contralateral testes. The immunoreactivity of iNOS and eNOS were increased in I/ R ipsilateral testicular groups. After I/ R, iNOS and eNOS expression increased slightly in contralateral groups. Additionally, the curcumin treatment decreased iNOS and eNOS immunoreactivity in ipsilateral and contralateral testes. Conclusion: The results suggest that curcumin did not protect the unilateral nor contralateral testes. This observation may depend on inhibition of iNOS and eNOS due to inhibition of the antioxidant, anti- inflammatory effects of nitric oxide. Copyright (C) 2008 S. Karger AG, Basel.Öğe The effects of methylene blue on renal scarring due to pyelonephritis in rats(Springer, 2007) Aksu, Burhan; Inan, Mustafa; Kanter, Mehmet; Puyan, Fulya Oz; Uzun, Hafize; Durmus-Altun, Gulay; Gurcan, SabanThe aim of this study was to evaluate the efficiency of methylene blue (MB) in preventing renal scar formation after the induction of pyelonephritis (PNP) in a rat model with delayed antimicrobial therapy. An inoculum of the K-12 strain of Escherichia coli was injected into both kidneys. Control groups received isotonic saline instead of bacterial solution. Four equal groups were then formed: the PNP group was untreated and the PNP ciprofloxacin (CIP) treated group was treated only with CIP intraperitoneally (i.p.) starting on the third day following bacterial inoculation. In the PNP (MB)-treated group, MB was given i.p., and in the PNP MB + CIP-treated group, MB + CIP were administered i.p.. In the sixth week following bacterial inoculation, all rats were sacrificed, and both kidneys of the rats in all groups were examined biochemically and histopathologically for renal scarring. Renal scar was significant in the groups treated with MB alone or MB + CIP combination compared with untreated or antibiotic only groups. Delayed treatment with antibiotics had no effect on scarring. These results suggest that the addition of MB to the delayed antibiotic therapy might be beneficial in preventing PNP-induced oxidative renal tissue damage.Öğe The effects of N-acetylcysteine on intestinal ischemia/reperfusion injury in rats(Saudi Med J, 2009) Ayvaz, Suleyman; Aksu, Burhan; Inan, Mustafa; Uzun, Hafize; Aydin, Seval; Bilgi, Selcuk; Umit, Hasan C.Objectives: To evaluate the effects of N-acetylcysteine (NAC) on the injury of intestinal ischemia-reperfusion. Methods: Forty-eight Wistar-Albino rats were divided into 6 groups: as control, ischemia, ischemia-reperfusion, ischemia + N-acetylcysteine, ischemia-reperfusion + N-acerylcysteine (IRN), and reperfusion + N-acetylcysteine (RN). Histopathologic examination was performed to all groups. In the tissue and plasma, and erythrocyte samples, malondialdehyde, superoxide dismutase, glutathione, and nitric oxide (NO) levels were evaluated. The present study was carried out in Trakya and Istanbul University, Edirne, Turkey between December 2002 and July 2003. Results: The most severe histopathological damage was seen in the intestinal ischemia-reperfusion group, and this damage was observed to be reduced by NAC administration. Lowest plasma malondialdehyde levels were observed in RN group. The tissue glutathione levels were found to be higher in RN group than those in IRN group. Conclusion: It was found that administration of NAC has important effects on the injury of intestinal ischemia, as well as, reperfusion in rats. N-acerylcysteine administration causes an improvement in the histopathologic findings of ischemia/reperfusion damages. The N-acerylcysteine treatment protects the antioxidant enzymes in the tissue, plasma, and the erythrocytes, which are crucially important in the intestinal schemia/reperfusion injury in rats.Öğe Effects of sphingosylphosphorylcholine against cholestatic oxidative stress and liver damage in the common bile duct ligated rats(W B Saunders Co-Elsevier Inc, 2009) Aksu, Burhan; Umit, Hasan; Kanter, Mehmet; Guzel, Ahmet; Inan, Mustafa; Civelek, Sabiha; Aktas, CevatThe goal of this study was to evaluate the possible protective effects of sphingosylphosphorylcholine (SPC) against cholestatic oxidative stress and liver damage in the common bile duct ligated rats. Fifty-six animals were included in each of the following 7 groups: control, SPC control, phosphate-buffered solution control, sham operated, bile duct ligation (BDL), BDL plus phosphate-buffered solution, and BDL plus SPC. Sphingosylphosphorylcholine was administered 14 days at a daily dose of 2 mu m/mL intraperitoneally. The severity of cholestasis and hepatic injury was determined by changes in the plasma enzyme activities of aspartate aminotransferase, alanine aminotransferase, gama glutamin transferase, and levels of total bilirubin and direct bilirubin. Malondialdehyde, nitric oxide, and superoxide dismutase were determined to evaluate the oxidative status in the liver tissue. Myeloperoxidase activity and levels of tissue hydroxyproline were determined to assess neutrophil activation and collagen accumulation, respectively. Treatment with SPC markedly reduced serum transaminase activities as compared to BDL rats. Sphingosylphosphorylcholine also inhibited the increase in liver malondialdehyde; nitric oxide levels significantly and also attenuated the depletion of superoxide dismutase in the liver after BDL. Similarly, the increase in tissue myeloperoxidase activity and hydroxyproline owing to BDL was also attenuated by the SPC treatment. These data were supported by histopathologic findings. The a-smooth muscle actin-positive cells in the BDL were observed to be reduced with the SPC treatment. In conclusion, these findings suggested that SPC can attenuate hepatic damage in extrahepatic cholestasis by prevention of oxidative stress, and inflammatory process. All these findings suggest that SPC may be a promising new therapeutic agent for cholestatic liver injury. (C) 2009 Elsevier Inc. All rights reserved.Öğe Esophageal duplication associated with esophageal atresia and tracheoesophageal fistula in a child(Elsevier Ireland Ltd, 2007) Inan, Mustafa; Basaran, Umit N.; Aksu, Burhan; Dereli, Murat; Dortdogan, ZaferEsophageal atresia with tracheoesophageal fistula is an uncommon congenital anomaly. Duplication of the gastrointestinal system is even more infrequent. We describe an unusual case of these two conditions occurring in the same children, although distal esophageal duplication was not recognized initially after repair of the esophageal atresia and tracheoesophageal fistula. (C) 2007 Elsevier Ireland Ltd. All rights reserved.Öğe Etiology of neonatal gastric perforations(Wiley, 2007) Duran, Ridvan; Inan, Mustafa; Vatansever, Uelfet; Aladag, Nuekhet; Acunas, BetuelBackground: Neonatal gastric perforation (NGP) is a rare event and its etiology is still controversial. Although it has previously been described as spontaneous, recently some risk factors have been reported to be associated with the development of NGP including prematurity and nasal ventilation. The purpose of the present paper was to report and discuss etiology, clinical features, and outcome of the authors' NGP cases over a 10 year period. Methods: Charts of five infants with NGP was reviewed in terms of gender, birthweight, gestational age, time of diagnosis, associated disease, site of perforation, type of surgery performed, and clinical outcome. Results: There were three boys and two girls with a mean birthweight and gestational age of 1650 g and 32 weeks, respectively. Three of them were premature. Mean perforation time was day 10 postnatally. Three infants had associated problems including prematurity, respiratory distress syndrome type 1, necrotizing enterocolitis, mechanical ventilator support, and one of them had tracheaesophageal fistula. Mothers of two out of these three infants had chorioamnionitis. One full-term infant received dexamethasone because of brain edema. Only one patient had no associated problem. Perforation occurred in the lesser curvature in three infants and in the greater curvature in two infants. Mortality rate was 60%. Conclusions: Contrary to previous literature, and similar to recent publications, it was found that essentially low-birthweight infants with tracheaesophageal fistula or chorioamnionitis and full-term babies on steroid therapy may have a risk for NGP, suggesting that an infant with contributing factors should be monitored more carefully for the development of NGP.Öğe Factors associated with childhood constipation(Blackwell Publishing, 2007) Inan, Mustafa; Aydiner, Cagatay Y.; Tokuc, Burcu; Aksu, Burhan; Ayvaz, Suleyman; Ayhan, Sinan; Ceylan, TuranAim: To evaluate factors associated with constipation, determine its risk factors and identify common methods of managing constipation among schoolchildren from ages 7-12 in Edirne, Turkey. Methods: This was a cross-sectional and descriptive study and 1900 children were stratified by the school population, age and gender. The questionnaire collected information from parents about the prevalence of constipation and associated factors as well. It asked about bowel movements, socio-demographic data, personal and family stressors, parental concern about constipation, and treatment methods. Results: The overall prevalence of constipation was 7.2%. It was 7.3% in boys and 7.2% in girls (P > 0.05). The parameters of siblings with health problems, constipation history in family members, abnormal oral habits, and little regular sporting activity were more common in constipated children than in non-constipated ones (P < 0.05). In the logistic regression analysis, never having used school toilets (OR: 5.9) and having problem to control their bowel after 2 years of age (OR: 3.1) were found to be major risk factors for constipation in schoolchildren ages 7-12 years. Constipated children had a lower consumption rate of fruits and vegetables and a higher consumption rate of milk-group foods, biscuits and macaroni than non-constipated children. Parental concern was at 90% and the rate of medical consultation was 23.2% for constipated children. Conclusions: The risk factors for childhood constipation may be genetic, psychological or organic. Bowel functions may be affected by dietary habits. Parents, health and education professionals should give special attention to childhood constipation.Öğe FOLLOW-UP AND RESULTS OF OUR VESICOURETERAL REFLUX DISEASES(Springer, 2018) Karaca, Zeynep; Ozkayin, Nese; Basaran, Umit; Inan, Mustafa; Aksu, Burhan; Altun, GUlay; Kucuk, Funda[Abstract Not Available]Öğe Hepatic hydatid disease in children and adults living in different areas in Turkey(Saudi Med J, 2007) Inan, Mustafa; Ayvaz, Suleyman; Baser, Murat; Karaayvaz, Muammer; Ciftci, Ali; Hatipoglu, Ahmet R.; Gul, HaticeObjective: To compare the clinical features of the hepatic hydatid disease in the operated children and adults living in the east and west part of Turkey. Methods: Between January 2001 and May 2005, 105 patients were operated with the diagnosis of hepatic hydatid cyst in Trakya and Yuzuncu Yil University Hospitals, Turkey. The patients (n=105) were retrospectively evaluated in 4 groups; Edirne Ch: (18 children under 18 year-old) and Edirne Ad: (20 adults) were from Edirne, Van Ch: (22 children under 18 year-old) and Van Ad: (44 adults) from Van. The patients in each group were analyzed according to their clinical and radiological findings. Results: The frequency of hepatic hydatid cysts in children was significantly higher in boys in Edirne Ch group and in girls in Van Ch group (p<0.05). In adults, the disease was also seen significantly higher in males in Edirne Ad group and females in Van Ad group (P<0.05). There were no difference symptoms of the disease, concomitant extra hepatic cysts and total cyst number in children and adults in the same region (p>0.05). The number of huge hepatic cysts and history of contact with animal were more common in children and adults living in Van. Conclusion: While the course of hepatic hydatid disease has the similar clinical features among the children and adults in the same region, remarkable regional differences have been found on it.Öğe Intestinal perforation: Rewiev of our experience in the neonatal period(Aves, 2007) Duran, Ridvan; Vatansever, Ulfet; Aksu, Burhan; Inan, Mustafa; Acunas, BetulAim: Despite rapid advances in neonatal intensive care, intestinal perforation (IP) has remained a major and life- threatening complication in neonates. Spontaneous intestinal perforation (SIP) is a recently defined entity, which is mostly seen in very low birthweight (VLBW) newborn infants. We want to report and discuss etiology, clinical features, and outcome of our IP cases. Material and Method: Charts of thirteen infants with IP was reviewed in terms of gender, birth weight, gestational age, day of perforation, diagnosis, location of perforation, type of surgery performed, and clinical outcome. Results: There were nine boys and four girls. Eight of them were preterm. Mean perforation time was day nine postnatally. 11 infants had the causes of IP including meconium ileus (n= 6), necrotizing enterocolitis (NEC) (n= 4), esophageal atresia (n= 1), following malrotation surgery (n= 1) and, three of them were on mechanical ventilator support. Two VLBW infants developed IP following oral ibuprofen administration. Perforation occurred in the distal ileum in the majority of infants. Conclusions: We found that essentially NEC, meconium ileus, and mechanical ventilation were associated with intestinal perforations and SIP following oral ibuprofen administration was observed in two preterm infants.
