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Öğe Additional Benefit of Canakinumab on Proteinuria in a Case With Muckle-Wells Syndrome in Remission Under Anakinra(Turkish League Against Rheumatism, 2020) Ilgen, Ufuk; Kucuksahin, Orhan[Abstract Not Available]Öğe Assessment of loneliness in patients with inflammatory arthritis(Wiley, 2021) Emmungil, Hakan; Ilgen, Ufuk; Turan, Sezin; Kilic, OzgeAim This study aimed to explore loneliness and associated factors in Turkish patients with inflammatory arthritis. Method Adult patients with rheumatoid arthritis (RA) (n = 58), ankylosing spondylitis (AS) (n = 53), and psoriatic arthritis (PsA) (n = 30), respectively, were included in the study. A single-item visual analog scale (VAS) for loneliness, UCLA Loneliness Scale-8 (ULS-8), Beck depression inventory (BDI), Beck anxiety inventory (BAI), revised multidimensional scale of perceived social support, Health Assessment Questionnaire-Disability Index (HAQ-DI) were used for the psychometric and functional assessments. Multiple regression models were generated for predicting the ULS-8 and HAQ-DI scores. Results There was no difference between disease groups in terms of the ULS-8 and HAQ-DI scores. Among demographic and clinical parameters, only the education status and number of drugs used had associations with the ULS-8 score. Single-item VAS score for loneliness did not predict the ULS-8 score well. There were significant correlations between the ULS-8 and HAQ-DI, depression, anxiety, social support, and physician global VAS scores. Only the education status significantly predicted (beta = -0.208) the ULS-8 score in multiple regression analysis (adjusted R-2 = 0.15, P < .001). Beck depression, anxiety, and patient global VAS scores remained significant for predicting the HAQ-DI after multiple regression with the covariates ULS-8, depression, anxiety, social support, patient and physician global VAS scores, and the number of drugs used (adjusted R-2 = 0.53, P < .001). Disease activity and the ULS-8 scores were not found to be associated in any disease group. Conclusion Loneliness is associated with depression, anxiety, lack of social support, disability, higher number of drugs used, and lower education but not with disease activity in Turkish patients with RA, AS, and PsA. Perception and expression of loneliness vary according to the cultural background. Single-item scales for loneliness may lack reliability compared to the more comprehensive ULS-8.Öğe ASSESSMENT OF LONELINESS IN PATIENTS WITH INFLAMMATORY ARTHRITIS(Bmj Publishing Group, 2019) Emmungil, Hakan; Ilgen, Ufuk; Turan, Sezin; Kilic, Ozge[Abstract Not Available]Öğe Association of simple hematological parameters with disease manifestations, activity, and severity in patients with systemic sclerosis(Springer London Ltd, 2020) Yayla, Mucteba Enes; Ilgen, Ufuk; Okatan, Ilyas Ercan; UsluYurteri, Emine; Torgutalp, Murat; Kelesoglu Dincer, Ayse Bahar; Aydemir Guloksuz, Emine GozdeIntroduction/objectives Neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), mean platelet volume (MPV), and red cell distribution width (RDW) may potentially reflect inflammatory status in systemic autoimmune diseases. The aim of this study is to investigate the association between these proposed markers and disease manifestations, activity, and severity in systemic sclerosis (SSc). Method We conducted a cross-sectional study of 69 systemic sclerosis (SSc) patients and 50 healthy volunteers in a single center. Adult patients with SSc and healthy controls were compared in terms of NLR, MLR, MPV, RDW, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP). Venous blood samples were drawn after at least 8 h of fasting in the morning. Extension of skin fibrosis was evaluated by using modified Rodnan skin score (mRSS). Disease severity and activity were assessed by Medsger disease severity and European Scleroderma Trials and Research Group (EUSTAR) disease activity scores, respectively. Associations of disease manifestations, clinical, laboratory, and capillaroscopic findings, mRSS, and the disease activity and severity scores with the proposed hematological markers were evaluated. Multiple regression models were generated for significant associations. Results The neutrophil number was higher (p = 0.004) and lymphocyte number was lower (p < 0.001) in SSc group compared to controls. SSc group also had higher NLR, MLR, and RDW. In multiple logistic regression, only the NLR (regression coefficient = 3.49, p = 0.031) and CRP (regression coefficient = 0.17, p = 0.037) remained significantly different between SSc and healthy control groups (Cox and Snell R-2 = 0.243, Nagelkerke R-2 = 0.337, p < 0.001). NLR and MLR positively correlated with mRSS, EUSTAR score, and CRP. MLR also positively correlated with Medsger score. Higher monocyte counts independently predicted higher EUSTAR and Medsger scores in multiple linear regressions. Patients with digital ulcers had higher NLR and MLR. We did not find any difference in MPV values between SSc and healthy control groups. Conclusions Globally available and inexpensive hematological tests, particularly the NLR and MLR, may be associated with vascular and cutaneous manifestations as well as disease activity and severity in SSc.Öğe Autoimmunity in psoriatic arthritis: pathophysiological and clinical aspects(Tubitak Scientific & Technological Research Council Turkey, 2021) EmmungIl, Hakan; Ilgen, Ufuk; DIreskenelI, Rafi HanerPsoriatic arthritis (PsA) is an underdiagnosed entity with a broad impact on the quality of life. Although the pathogenesis is largely unknown, autoimmune footprints of the inflammation in PsA have increasingly been recognized. Most of the genetic variation predisposing to PsA is mapped to the class I major histocompatibility complex (MHC) region and shared by a variety of autoimmune diseases. Polymorphisms in the genes IL12B, IL23R, IL13, TNIP1, TRAF3IP2, TYK2, and many others explain the non-HLA genetic risk with little known functional consequences. Entheseal and synovial cellular infiltrate with oligoclonal CD8(+) T cells and occasional germinal centers, loss of regulatory T cell function, and specific autoantibodies such as anti-PsA peptide, anti-LL-37, and anti-ADAMTSL5 are the immunopathological findings suggestive of autoimmunity. 'hese were supported by clinical observations of autoimmune multimorbidity and treatment response to calcineurin/mTOR and co-stimulation inhibition.Öğe Clusters in Behcet's syndrome(Bmc, 2022) Ilgen, UfukClustering is an important clinical feature of Behcet's syndrome (BS) and may have pathogenetic and therapeutic implications. Recent and previous studies on BS phenotype differ substantially in terms of methodology. Correlation matrices and factor analyses were not efficient enough to uncover clusters. Clustering patterns may change according to demographic factors such as age and sex. Clustering patterns may also be profoundly influenced by the misperception of symptoms that are assumed to be secondary to BS, when, in fact, they represent manifestations of BD mimics. This can give rise to misleading conclusions and should be kept in mind when interpreting data obtained by clustering or other phenotype analyses of BS. A true geographical/racial variability in disease expression could be studied in a multinational consensus cohort. Pathogenetic studies in separate clusters of BS have still been lacking.Öğe Colchicine Intolerance: Does the Pharmaceutical Preparation Matter?(Galenos Publ House, 2021) Ilgen, Ufuk; Emmungil, Hakan; Kucuksahin, Orhan[Abstract Not Available]Öğe Complexity of familial Mediterranean fever genetics(Aves, 2020) Ilgen, Ufuk[Abstract Not Available]Öğe Correlation Between Prognostic Nutritional Index and Primary Sjogren's Syndrome Disease Activity(Wiley, 2021) Kalkan, Kbra; Ilgen, Ufuk; Ademoglu, Zeliha; Emmungil, Hakan[Abstract Not Available]Öğe Diaphragmatic muscle ultrasonography and sarcopenia in older people(Springer, 2021) Ilgen, Ufuk; ozbas, Burak; Karatas, Ali; Kilic, Guner; Kocyigit, Suleyman Emre[Abstract Not Available]Öğe Different Colchicine Preparations for Familial Mediterranean Fever: Are They the Same?(Wiley, 2019) Emmungil, Hakan; Ilgen, Ufuk; Turan, Sezin; Yaman, Samet; Kucuksahin, Orhan[Abstract Not Available]Öğe Different pharmaceutical preparations of colchicine for Familial Mediterranean Fever: are they the same?(Springer Heidelberg, 2020) Emmungil, Hakan; Ilgen, Ufuk; Turan, Sezin; Yaman, Samet; Kucuksahin, OrhanThis study aimed to investigate the benefit of changing the pharmaceutical preparation of colchicine in Turkish Familial Mediterranean Fever (FMF) patients resistant to one preparation in terms of frequency of the attacks. Turkish adult FMF patients under treatment with an imported colchicine preparation-in the form of compressed tablet form-due to resistance to domestic colchicine preparations, which are film-or sugar-coated tablets, and not using anti-interleukin-1 or other biologic agents were included in the study. Baseline disease characteristics along with MEFV mutations were identified. Daily colchicine doses and attack frequencies before and after the pharmaceutical change were compared. Fifty patients resistant to coated tablet preparations of colchicine and under treatment with the compressed tablets were identified. The median duration of disease was 6 (interquartile range 2.7-14) years and duration under treatment with the imported colchicine was 21 (range 8-60) months. Eight (16%), ten (20%), and 32 (64%) patients had 0-3, 4-6, and more than 7 attacks per year, respectively, before the compressed tablets. After treatment with the compressed tablet form of colchicine, 44 (88%), 5 (10%), and 1 (2%) patients had 0-3, 4-6, and more than 7 attacks, respectively ( p < 0.0001). Daily colchicine doses were similar before and after the pharmaceutical change (1.85 +/- 0.47 vs 1.84 +/- 0.37 mg, p = 0.9). Turkish FMF patients with ongoing attacks under domestic coated tablet preparations of colchicine may benefit from the compressed colchicine tablets. This may be explained by the difference in pharmacokinetic properties of different colchicine preparations.Öğe Enteropathic Arthritis Beyond the Criteria(Oxford Univ Press Inc, 2022) Ilgen, Ufuk; Emmungil, Hakan[Abstract Not Available]Öğe Fetal exposure to canakinumab: a report of three pregnancies(Springer London Ltd, 2022) Ilgen, Ufuk; Eyupoglu, Sahin; Yayla, Mucteba Enes; Kucuksahin, Orhan[Abstract Not Available]Öğe Imaging in myositis: MRI or 18F-FDG PET/CT?(Springer London Ltd, 2022) Ilgen, Ufuk; Emmungil, Hakan[Abstract Not Available]Öğe Intraclass correlation coefficient and reliability of muscle mass measurements(Wiley, 2021) Ilgen, Ufuk; Ucar, Ismail[Abstract Not Available]Öğe Less IgA deposits with more severe disease: the immunoclinical paradox in Henoch-Schonlein Purpura with MEFV mutations(Springer London Ltd, 2019) Ilgen, Ufuk; Nergizoglu, Gokhan[Abstract Not Available]Öğe On the Coexistence of Takayasu Arteritis and Inflammatory Bowel Disease(Lippincott Williams & Wilkins, 2021) Ilgen, Ufuk; Emmungil, Hakan; Tezel, Huseyin Ahmet[Abstract Not Available]Öğe Pigmented villus fragments on synovial fluid examination(Aves, 2022) Ilgen, Ufuk; Emmungil, Hakan[Abstract Not Available]Öğe A Rare Case of Granulomatosis With Polyangiitis With Cardiac and Splenic Involvements(Lippincott Williams & Wilkins, 2020) Turan, Sezin; Ilgen, Ufuk; Kalkan, Kubra Erol; Ustabasioglu, Fethi; Can, Nuray; Emmungil, Hakan[Abstract Not Available]