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    The Effect of Auricular Graft Donor Site on Morbidity and Cosmetic Appearance in Cartilage Tympanoplasties
    (Aves, 2020) Huseyinoglu, Aydin; Uzun, Cem; Koder, Ahmet; Yagiz, Recep; Benlier, Erol; Bulut, Erdogan
    OBJECTIVES: The aim of the present study was to compare the postoperative morbidity and cosmetic results between the use of the scapha and the use of the tragus as the auricular cartilage graft donor site in patients who had undergone cartilage tympanoplasty. The fascia graft was used as the control. MATERIALS and METHODS: The patient's visual symmetry, cosmetic satisfaction, and anthropometric measurements were studied to objectively evaluate the cosmetic condition. The formation of skin scar changes, pigmentation changes, and sensory changes as clinical criteria were compared. RESULTS: A total of 234 patients and their 257 operated ears were included in the study. Forty prospectively operated ears with preoperative findings were also included. All patients (100%) felt that their results were good, as indicated by the visual analog scale, and the anthropometric ear measurements used to reinforce the data showed no significant differences between the groups. A significant difference with respect to clinical sensory changes was found between the groups only in patients undergoing unilateral surgery via the retro auricular approach (p<0.05). There was no difference between the scapha and tragus groups with respect to scar formation or skin pigmentation change. CONCLUSION: Neither scapha nor tragus use for graft retrieval led to dissatisfaction or cosmetic problems in the postoperative period. Sensory changes in the skin on clinical evaluation were less common in patients in whom the scapha donor site was preferred than in cases in which the tragus was used.
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    Effects of Intratympanic Steroid on Cisplatin Ototoxicity: An Electrophysiological and Ultrastructural Study
    (Akad Doktorlar Yayinevi, 2018) Tas, Abdullah; Bulut, Erdogan; Tas, Memduha; Yagiz, Recep; Turan, Pinar; Huseyinoglu, Aydin; Karasalihoglu, Ahmet R.
    Ototoxicity refers to the inner ear dysfunction caused by a drug or a chemical agent which manifests as hearing loss or balance impairment, or both. Currently, antibiotics, diuretics, anti-inflammatory drugs, antineoplastic agents, antimalarial drugs and some other agents are known to cause ototoxicity. Cisplatin is an antineoplastic agent for which the ototoxicity incidence may vary based on the treatment protocol. In the present study, we aimed to perform an electrophysiological and ultrastructural evaluation regarding the protective effectiveness of intratympanic steroids on cisplatin ototoxicity. Electrophysiological assessment included tympanometry and auditory brainstem response (ABR), and 16 guinea pigs (32 ears) with normal hearing were randomly assigned to 4 groups as follows: control, cisplatin, cisplatin/steroid and cisplatin/physiological saline. Following the electrophysiological measurements, temporal bones were dissected for ultrastructural examinations. In the cisplatin group, a statistically significant (p<0.05) threshold difference was noted for the ABR test versus the other groups while this threshold difference was lower in the cisplatin/steroid group compared to the other groups. Ultrastructural evaluations revealed abnormal outer hair cell stereocilia morphology and severe degenerative changes in the cisplatin and cisplatin/physiological saline groups. Mild degenerative alterations were seen in the outer hair cell stereocilia morphology in the guinea pig cochlea administered with intratympanic steroid. We believe intratympanic steroid administration showed protective effectiveness on the cisplatin-induced ototoxic damage in our study.