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Öğe The comparison of electron microscopy and scintigraphy in determining the protective effect of dimethylsulphoxide (DMSO) on ischemia/reperfusion injury through pringle maneuver(H G E Update Medical Publishing S A, 2001) Hatipoglu, AR; Temiz, E; Yüksel, M; Hoscoskun, Z; Coskun, I; Hüseyinova, GBackground/Aims: We investigated the role of the electron microscopy and hepatobiliary scintigraphy in determining the effect of DMSO (dimethysulphoxide) and ischemia/reperfusion injury in the liver after the Pringle maneuver. Methodology: Twenty-four rabbits were divided into the following groups; A: Control group, B: Pringle, C: 10mg/kg DMSO, D: 1g/kg DMSO + Pringle. Group A was considered as a control group and only laparotomy was applied. Group B was exposed to Pringle maneuver only. Group C:was given 10mg/kg of DMSO via the vena cava inferior. Group D was given 1g/kg of DMSO- A clamp was fastened for the groups of B, C and D in the 30th minute of the Pringle maneuver and a biopsy was applied five minutes later. Fifteen minutes later a dynamic hepatobiliary scintigraphy was applied. From dynamic images, liver peak time and activity half time of the liver were obtained. Results: It was found that liver peak time and liver activity half time values of the group B, C and D were significantly longer than group A. Liver peak time and liver activity half time values of group B was not different from group C. However, some values of group D were found to be significantly shorter than groups B and C. In the electron microscopy examination, only in group B were some specific degenerative changes observed in the sinusoids. We observed less irreversible changes in group C than in group B. Oh the other hand, the least irreversible changes were in group D. Conclusions: As a conclusion, while electron microscopy is regarded as the gold standard, hepatobiliary scintigraphy may be thought of as an easily applicable: method in determining the ischemic reperfusion injury in the clinical comparison of the protective agents.Öğe Laparoscopic repair of inguinal hernia(Monduzzi Editore, 1997) Hoscoskun, Z; Hatipoglu, AR; Ahsen, MLaparoscopic herniorrhaphy performed to 15 patients with inguinal hernias, between May-1994 and December-1996 at the Trakya University Faculty of Medicine Department of Surgery, were evaluated. All the patients were male. The ages of patients varied between 20 and 67 (mean 47,13). 10 right inguinal hernias, 4 left inguinal hernias and one bilateral inguinal hernia were presented. Hernia repair was performed with TAPP in 12 patients and with TEP in 3 patients. All of the operations were achieved with laparascopic technique. In TAPP group, minor complication was seen in 3 patients. There were no complication in TEP group. Average operation time was 156 min. for TAPP, 100 min. for TEP. Hospitalization period averaged 24,55 hrs. for TAPP, 24 hrs. for TEP. Returning to daily activity was 2,5 days for TAPP, 2 days for TEP.Öğe The results of 96 cases applied laparoscopic cholecystectomy(Monduzzi Editore, 1997) Hatipoglu, AR; Hoscoskun, Z; Ahsen, MIn this study, 96 laparoscopic cholecystectomy cases performed by two surgeons, between March-1993 and January-1997 at the Trakya University Faculty of Medicine Department of Surgery, were evaluated. The age of the patients varied between 21-77. Cholecystectomy was completed with open technique in 8 cases (9,09%). Subcutaneous emphysema was found in one patient, subcutaneous hemathoma in the other one. Intraabdominal bleeding occured in 3 patients (3,40%). While 2 of them were being treated by conservative methods, laparatomy was needed for the other patient. Mortality was not seen. Average operation time was 90,6 min. Finally, in experinced hands, laparascopic cholecystectomy may Se performed safely as the open technique.