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Öğe Evaluation of quality of life, anxiety, and depression in the spouses of patients with obstructive sleep apnea syndrome(Wolters Kluwer Medknow Publications, 2019) Yazici, O.; Hatipoglu, O. N.Background: Impaired quality of life can be seen in the spouses of the obstructive sleep apnea syndrome (OSAS) patients. The main aim of the study is to assess the quality of life, anxiety, and depression in the spouses of the OSAS patients. Materials and Methods: A total of 100 OSAS patients and their spouses were included in the study. The demographic features of patients and the findings related to their disease and relevant clinical conditions were recorded. The quality of life of the spouses was evaluated by Short Form-36, their depression levels by Beck's depression inventory (BDI), anxiety levels by Beck's anxiety inventory, and the hospital anxiety and depression scale (HADS). Results: About 33% and 26% of patients' spouses showed depression by BDI and HADS, respectively; 14% of them showed anxiety by hospital anxiety scale. Among the subparameters of quality of life in spouses of patients who receive PAP (positive airway pressure) treatment, scores of physical condition, physical role restrictions, and role restrictions due to emotional problems were significantly higher than the ones in spouses of nontreated patients (P < 0.05). Depression scores of spouses of patients who use PAP were significantly lower than the ones who do not use the device (P < 0.05). A significant difference was not found between the two groups by means of anxiety scores (P 0.05). Conclusion: The use of continuous PAP improves not only the quality of life for OSAS patients but also for their spouses and reduces the spouses' depression risk.Öğe High plasma d-dimer level is associated with decreased survival in patients with lung cancer(Elsevier Science London, 2007) Altiay, G.; Ciftci, A.; Demir, M.; Kocak, Z.; Sut, N.; Tabakoglu, E.; Hatipoglu, O. N.Aims: An elevated plasma D-dimer level indicates the activation of coagulation and fibrinolysis. In the present study, we investigated the association of pre-treatment haemostatic parameters (D-dimer, fibrinogen and prothrombin fragment 1 + 2) with clinicopathological parameters and outcome in patients with lung cancer. Materials and methods: Plasma levels Of D-dimer and other parameters were measured in 78 evaluable patients with lung cancer (60 non-small cell lung cancers, 18 small cell lung cancers). At diagnosis, 35 patients (44.9%) were locally advanced stage (IIIA/B) and 43 patients (55.1%) had metastatic disease (IV). Multivariate statistical analysis was carried out using Cox's proportional hazards model. The receiver operating characteristic curve was used to determine the cutoff values for D-dimer, fibrinogen and prothrombin fragment 1 + 2. Results: The median survival for all patients was 264 days (95% confidence interval 200-328 days). A significant association between the plasma levels Of D-dimer and the response to chemotherapy was observed (P = 0.03). With the univariate analysis, tumour stage, pre-treatment plasma levels Of D-dimer, fibrinogen, platelet count, lactate dehydrogenase concentration and Karnofsky performance status were predictive for survival. With the multivariate analysis (P <= 0.11), the plasma level Of D-dimer (P < 0.001), tumour stage (P = 0.01) and Karnofsky performance status (P = 0.02) were identified as independent predictive factors. The median survival times were 405 days (95% confidence interval 165-644 days) and 207 days (95% confidence interval 146-267 days, P < 0.001), respectively, for patients with a low D-dimer level (<= 0.65 mu g/ml) and a high D-dimer level (> 0.65 mu g/ml). Conclusions: Elevated plasma levels Of D-dimer in patients with lung cancer are associated with decreased survival and a poor response to treatment. Pre-treatment for the D-dimer level may be useful in the prediction of survival and the response to treatment.Öğe THE PREDICTORS OF LONG-TERM SURVIVAL AND MORTALITY IN PATIENTS WITH COPD TREATED WITH MECHANICAL VENTILATION(Wiley-Blackwell, 2016) Altiay, G.; Yasin, M.; Sut, N.; Tabakoglu, E.; Hatipoglu, O. N.[Abstract Not Available]
