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Öğe The comparison of electron microscopy and scintigraphy in determining the protective effect of dimethylsulphoxide (DMSO) on ischemia/reperfusion injury through pringle maneuver(H G E Update Medical Publishing S A, 2001) Hatipoglu, AR; Temiz, E; Yüksel, M; Hoscoskun, Z; Coskun, I; Hüseyinova, GBackground/Aims: We investigated the role of the electron microscopy and hepatobiliary scintigraphy in determining the effect of DMSO (dimethysulphoxide) and ischemia/reperfusion injury in the liver after the Pringle maneuver. Methodology: Twenty-four rabbits were divided into the following groups; A: Control group, B: Pringle, C: 10mg/kg DMSO, D: 1g/kg DMSO + Pringle. Group A was considered as a control group and only laparotomy was applied. Group B was exposed to Pringle maneuver only. Group C:was given 10mg/kg of DMSO via the vena cava inferior. Group D was given 1g/kg of DMSO- A clamp was fastened for the groups of B, C and D in the 30th minute of the Pringle maneuver and a biopsy was applied five minutes later. Fifteen minutes later a dynamic hepatobiliary scintigraphy was applied. From dynamic images, liver peak time and activity half time of the liver were obtained. Results: It was found that liver peak time and liver activity half time values of the group B, C and D were significantly longer than group A. Liver peak time and liver activity half time values of group B was not different from group C. However, some values of group D were found to be significantly shorter than groups B and C. In the electron microscopy examination, only in group B were some specific degenerative changes observed in the sinusoids. We observed less irreversible changes in group C than in group B. Oh the other hand, the least irreversible changes were in group D. Conclusions: As a conclusion, while electron microscopy is regarded as the gold standard, hepatobiliary scintigraphy may be thought of as an easily applicable: method in determining the ischemic reperfusion injury in the clinical comparison of the protective agents.Öğe Comparison of the protective effects of dimethylsulphoxide and methylprednisolone against the warm ischemia on liver parenchima using hepatobiliary scintigraphy(Springer-Verlag, 2001) Yüksel, M; Hatipoglu, AR; Terniz, E; Saihoglu, YS; Berkarda, S; Yigitbas, ON[Abstract Not Available]Öğe Laparoscopic repair of inguinal hernia(Monduzzi Editore, 1997) Hoscoskun, Z; Hatipoglu, AR; Ahsen, MLaparoscopic herniorrhaphy performed to 15 patients with inguinal hernias, between May-1994 and December-1996 at the Trakya University Faculty of Medicine Department of Surgery, were evaluated. All the patients were male. The ages of patients varied between 20 and 67 (mean 47,13). 10 right inguinal hernias, 4 left inguinal hernias and one bilateral inguinal hernia were presented. Hernia repair was performed with TAPP in 12 patients and with TEP in 3 patients. All of the operations were achieved with laparascopic technique. In TAPP group, minor complication was seen in 3 patients. There were no complication in TEP group. Average operation time was 156 min. for TAPP, 100 min. for TEP. Hospitalization period averaged 24,55 hrs. for TAPP, 24 hrs. for TEP. Returning to daily activity was 2,5 days for TAPP, 2 days for TEP.Öğe Laparoscopic versus open cholecystectomy: Effect on pulmonary function tests(H G E Update Medical Publ Ltd., 2000) Coskun, I; Hatipoglu, AR; Topaloglu, A; Yoruk, Y; Yalcinkaya, S; Caglar, TBackground/Aims: Operations often cause impairment in respiration due to pain. This study was designed to compare the changes in pulmonary function tests after open and laparoscopic cholecystectomy. Methodology: Two groups of 35 patients were randomly set up. Each patient had 3 pulmonary function tests performed and 2 postero-anterior grid chest roentgenograms taken. All of these data were evaluated by the same group of investigators. Results: After taking into consideration the difference between pulmonary function tests, values were not significant (P less than or equal to 0.05). All pulmonary function test values decreased significantly on the 1st postoperative day (P less than or equal to 0.05). When postero-anterior chest roentgenograms were compared no clinically evident atelectasis except 3 lineary was seen in the laparoscopic cholecystectomy group, whereas 5 lineary, 7 focal, and 3 segmentary atelectasia were encountered in the open cholecystectomy group (P less than or equal to 0.05). Conclusions: We believe that laparoscopic cholecystectomy has more advantages when speaking of postoperative pulmonary function tests and atelectasia.Öğe A rare cause of acute abdomen(H G E Update Medical Publ Ltd., 2001) Hatipoglu, AR; Karakaya, K; Karagülle, E; Turgut, BSplenic infarction is a rare disorder. We have treated 4 patients during the last year. Abdominal pain in the left upper quadrant was the common complaint. Other complaints were fever, nausea and vomiting. Computed tomography showed infarcted areas in the spleen in all of the patients. S plenectomy was applied to three of the patients with recurring symptoms. The other patient had the first episode treated medically. Pulmonary embolism in one and surgical wound infection occurred in another patient during postoperative follow-up for nine (range: 4-14) months.Öğe The results of 96 cases applied laparoscopic cholecystectomy(Monduzzi Editore, 1997) Hatipoglu, AR; Hoscoskun, Z; Ahsen, MIn this study, 96 laparoscopic cholecystectomy cases performed by two surgeons, between March-1993 and January-1997 at the Trakya University Faculty of Medicine Department of Surgery, were evaluated. The age of the patients varied between 21-77. Cholecystectomy was completed with open technique in 8 cases (9,09%). Subcutaneous emphysema was found in one patient, subcutaneous hemathoma in the other one. Intraabdominal bleeding occured in 3 patients (3,40%). While 2 of them were being treated by conservative methods, laparatomy was needed for the other patient. Mortality was not seen. Average operation time was 90,6 min. Finally, in experinced hands, laparascopic cholecystectomy may Se performed safely as the open technique.Öğe Retroperitoneal localization of hydatid cyst disease(H G E Update Medical Publ Ltd., 2001) Hatipoglu, AR; Coskun, I; Karakaya, K; Ibis, CIn this study we discuss a rare case; hydatid cyst disease that is located in the retroperitoneum. Two cases were treated in our department with hydatid cyst disease located in the retroperitoneum; one of the cysts was in the minor pelvis and the other was on the left psoas muscle. Diagnosis was confirmed with blood tests, and radiological examinations. The cyst wall was excised partially and was oversewn. Following the operation both of the patients were given albendasole tablets for 10 weeks with blood count and liver enzyme monitorization. Hydatic cysts located in retroperitoneum were treated successfully. Especially in the endemic areas hydatid cyst should be remembered when evaluating cystic masses in the retroperitoneum. It can be treated successfully with surgery.
