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Öğe 99mTc(V)-DMSA scintigraphy in monitoring the response of bone disease to vitamin D3 therapy in renal osteodystrophy(Springer, 2002) Sarikaya, A; Sen, S; Hacimahmutoglu, S; Pekindil, GRenal osteodystrophy (ROD) is a common and serious complication for uremic patients and patients are treated with 1,25-dihydroxy vitamin D-3. The bone scanning agent Tc-99m-phosphate has also been used to evaluate in ROD but it is not clear that bone scintigraphy has a role in the follow-up of treatment. In this study Tc-99m(V)-DMSA scintigraphy was performed in eleven patients [age 40.7 +/- 17.3 (mean +/- SD) yr] with ROD before and after vitamin D-3 therapy. Images were obtained after hemodialysis performed following tracer injection to maintain normal blood levels of the radiopharmaceutical and to reduce soft tissue activity. Lumbar vertebra-to-soft tissue uptake ratios (LUR) were quantified with the planar Tc-99m(V)-DMSA images. Alkaline phosphatase and parathyroid hormone levels after treatment had significantly decreased compared with pre-therapy. In all patients there was visually decreased uptake in bone structures after treatment. After treatment the mean LUR ratio was significantly lower than those of before treatment (3.59 +/- 2.63 vs. 1.65 +/- 0.62; p = 0.01). LUR values were correlated with pre-therapy alkaline phosphatase and parathyroid hormone. These findings indicate that Tc-99m(V)-DMSA scintigraphy is sensitive in evaluating the response of ROD to vitamin D-3 therapy.Öğe Clearance of technetium-99m-labeled DTPA in hyperthyroidism without clinical evidence of lung disease, and relation to pulmonary function(Springer, 2005) Guldiken, S; Tugrul, A; Altiay, G; Hacimahmutoglu, S; Durmus-Altun, GObjective: The mechanisms of dyspnea and exercise intolerance have not been fully elucidated. We aimed to investigate the clearance rate of technetium-99m diethyltriaminepentaaceticacid (Tc-99m DTPA) from lungs in hyperthyroid patients without clinical evidence of lung disease and to explore the interactions between their Tc-99m DTPA radioaerosol lung scintigraphy, spirometric measurements, and the levels of thyroid hormones. Methods: We studied 19 hyperthyroid patients and 16 sex- and age-matched controls. Thyroid hormone levels were assessed. Spirometric lung function tests, diffusing capacity of the lung for carbon monoxide (DLCO) and the clearance rate of Tc-99m DTPA were performed in all participants. Ratio of DLCO value to the alveolar ventilation (DLCO/VA) and the means of half-time (T-1/2) of Tc-99m DTPA clearance rate, which were used to evaluate alveolar-capillary membrane permeability, were calculated. Results: There were no statistical differences between spirometfic parameters (VC, FVC, FEV1/FVC, FEF 25-75) of the two groups (p > 0.05). Although the mean FEV1 level was significantly lower in the hyperthyroid patients than the control subjects (p < 0.01), in five patients FEV1 was only less than 80 percent of the predicted value. No significant difference in the means of DLCO, DLCO/VA or T-1/2 values of Tc-99m DTPA clearance was observed between the two groups (p > 0.05). In hyperthyroid patients, there was a positive relation between DLCO/VA, DLCO/VA % and T-1/2 values of Tc-99m DTPA clearance (p < 0.01, r = 0.732, p < 0.01, r = 0.742, respectively). The lung volumes and the levels of thyroid hormones did not show a significant relationship to T-1/2 values of Tc-99m DTPA clearance in hyperthyroid group (p > 0.05). Conclusions: We conclude that increased thyroid hormones have no effect on permeability of alveolar-capillary membrane in hyperthyroid patients.Öğe Irbesartan has a masking effect on dipyridamole stress induced myocardial perfusion defects(Lippincott Williams & Wilkins, 2004) Altun, GD; Altun, A; Yildiz, M; Firat, MF; Hacimahmutoglu, S; Berkarda, SBackground and aim The angiotensin 11 type 1 (AT(1)) receptor antagonist irbesartan is used for the treatment of hypertension, but its anti-ischaemic effect is not yet known. Our aim was to assess the effect of irbesartan administration on the diagnostic yield of Tc-99m sestamibi single photon emission computed tomography (SPECT) in patients with coronary artery disease (CAD) after dipyridamole stress. Methods Our study group consisted of 13 patients (11 men and two women; mean age, 53.3 +/- 10.6 years; body mass index, 26.9 +/- 3.3 kg.m(-2)) with angiographically documented CAD. All patients underwent Tc-9m sestamibi SPECT studies at rest, before (STRESS-1) and 2 weeks after irbesartan (150 mg daily) administration (STRESS-2) at dipyridamole stress. The extent and severity of defects were analysed by using visual and quantitative Tc-99m sestamibi SPECT. Results The mean summed stress score was significantly higher during the STRESS-1 study than the STRESS-2 study (13.2 +/- 7.4 vs. 11 +/- 74, P=0.003). The mean size of perfusion defects at stress was significantly larger for the STRESS-1 group than the STRESS-2 group (17.8% +/- 2.85% vs. 15.3% +/- 2.95%, P=0.01). Conclusion Our study showed that the AT(1) receptor blocker irbesartan reduces the extent and severity of Tc-99m sestamibi perfusion defects after dipyridamole stress in patients with CAD. Irbesartan may alter coronary blood flow reserve. The continued use of irbesartan before stress myocardial perfusion SPECT has a masking effect on stress induced myocardial perfusion defects. For this reason AT(1) receptor blockers must be stopped before stress myocardial perfusion scintigraphic examinations. (C) 2004 Lippincott Williams Wilkins.Öğe Tc-99m MDP and Tl-201 scintigraphy in a case of metastatic meningeal hemangiopericytoma(Lippincott Williams & Wilkins, 2001) Kaya, M; Cermik, TF; Hacimahmutoglu, S; Salan, A; Saridogan, K; Cakir, B; Yigitbasi, ON[Abstract Not Available]Öğe Tc-99m MIBI filling pattern in a photopenic area of a Tc-99m MDP scan in a patient with metastatic bone involvement of breast carcinoma(Lippincott Williams & Wilkins, 2002) Altun, GD; Uzal, C; Hacimahmutoglu, S; Pekindil, G; Sarikaya, A; Yigitbasi, NÖA 71-year-old woman had locally advanced invasive breast cancer in July 1997. She underwent modified radical mastectomy for left breast cancer in October 1997 after she had been treated with six of courses neoadjuvant chemotherapy and local radiation therapy. She was referred for bone scintigraphy due to bone pain in September 1999. The bone scan showed metastatic involvement in the left temporoparietal area as increased Tc-99m MDP uptake with large central photopenia. The computed tomographic (CT) scan of the cranium revealed lytic bone lesions located in the same region, which was irregularly contoured. Tc-99m MIBI imaging was performed 1 week after the bone scan. Increased uptake without central photopenia was observed in the same area as the bone scan abnormality. It was described as a Tc-99m MIBI filling pattern of the photopenic area seen with Tc-99m MDP.Öğe Tc99m MIBI scintigraphy in metastatic bone involvement of breast cancer(Springer-Verlag, 2001) Altun, GD; Uzal, C; Hacimahmutoglu, S; Pekindil, G; Sarikaya, A[Abstract Not Available]
