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    A 48-month randomized controlled trial of caries prevention effect of a one-time application of glass ionomer sealant versus resin sealant
    (Japanese Soc Dental Materials Devices, 2016) Haznedaroglu, Eda; Guner, Sirin; Duman, Canan; Mentes, Ali
    The aim of this study was to compare the caries prevention effectiveness, retention rates and the level of fluoride of saliva of a glass-ionomer sealant (GIS) with that of a resin-based sealant (RS). Eighty GIS and 80RS were placed on the first permanent molars in 40 children aged 7-10 years. Children were re-examined at 6, 12, 24, 36 and 48 months after the procedure. Saliva samples were collected before the sealant was applied and again at each appointment, and fluoride levels were measured. After 48 months, occlusal caries were seen in 4 and 12 teeth in GIS and RS groups respectively. There was a statistically significant difference in the fluoride levels of saliva between baseline and up to 12th month in GIS group. GISs presented effective prevention of caries development, even though the failure rate is higher when compared to the RSs. An increased salivary fluoride level due to GISs might be an additive effect on the prevention of dental caries.
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    Dental Fluorosis and Catalase Immunoreactivity of the Brain Tissues in Rats Exposed to High Fluoride Pre- and Postnatally
    (Humana Press Inc, 2016) Guner, Sirin; Uyar-Bozkurt, Suheyla; Haznedaroglu, Eda; Mentes, Ali
    This study evaluated dental fluorosis of the incisors and immunoreactivity in the brain tissues of rats given chronic fluoride doses pre- and postnatally. Female rats were given drinking water with 0, 30 or 100 ppm fluoride ad libitum throughout gestation and the nursing period. In addition, 63 male offspring were treated with the same water regimens as the mothers after weaning and were followed for 1, 3 or 5 months. The upper and lower incisors were collected, and all teeth were examined under a stereomicroscope and scored by two blinded examiners using a modified rodent enamel fluorosis index. Cortical, hippocampal and cerebellar brain samples were evaluated morphologically and immunohistochemically. All fluoride-treated pups were born with low body weight (p = 0.001). All animals from the fluoride groups had enamel fluorosis with defects of various degrees. The increase in the dental fluorosis scores in the fluoride treatment groups was significant (p < 0.01). The catalase immunoreactivity in the 30- and 100-ppm fluoride groups was significantly higher than that in the controls after 1, 3 and 5 months (p < 0.001). In conclusion, this study showed that rats with dental fluorosis had catalase immunoreactivity in the brain tissues, which may reflect the neurobehavioral toxicity of fluoride.
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    FLUORINE ACCUMULATIONS IN DRINKING WATER OF HAVSA DISTRICT (EDIRNE, TURKEY) AND ASSESSMENT OF WATER QUALITY IN TERMS OF TEETH HEALTH
    (Yildiz Technical Univ, 2018) Tokatli, Cem; Guner, Sirin
    This study was carried out to determine the fluorine accumulations in groundwater of Havsa District, where is located in the Edirne Province of Turkey in Thrace Region. Drinking water samples were collected from 15 stations including almost all the residential areas of the Havsa District in winter season of 2016. Fluorine concentrations of water samples were determined by using a spectrophotometer and Cluster Analysis (CA) was applied to detected data in order to classify the groundwater of investigated residential areas according to fluorine contents. Geographic Information System (GIS) was also used in order to make a visual explanation by presenting distribution map of fluorine contents and detected data were evaluated according to national and international quality criteria. And also the detected data were evaluated in terms of teeth health of local people, who constantly drinks this water. According to data observed, the fluorine concentrations in the Havsa District were determined between 0.006 ppm (Bakislar Village) - 0.567 ppm (Haskoy Village). According to the results of CA, 2 statistically significant clusters were formed as Updistrict Cluster with higher fluorine contents and Downdistrict Cluster with lower fluorine contents.