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Öğe Comparison of Protective Effects of Melatonin and Amifostine on Radiation-Induced Renal Oxidative Stress in Rats(Hellenic Veterinary Medical Soc, 2020) Cakina, S.; Gulyasar, T.; Ozen, A.; Parlar, S.; Cukur, Z.; Kurkcu, N.; Uzal, C.In this study, we aimed to compare the protective effects of melatonin and amifostine on radiation-induced oxidative stress. Fifty female Wistar rats (3-4 months old, weighing 200 +/- 25 g) were divided into five groups (with ten rats each) and treated as follows: control (Cont), radiotherapy alone (RT), radiotherapy + amifostine (RT+A-MI), radiotherapy + melatonin (RT+MEL), radiotherapy + amifostine + melatonin (RT+AMI+MEL). Rats were irradiated individually with a single dose of 8 Gy and amifostine (200 mg/kg) and melatonin (10 mg/kg) was administered to rats 30 minutes before irradiation. At the end of this follow-up period (72 hours) the rats were sacrificed. Spectrophotometric Analysis has been performed to kidney tissue samples. As a result of statistical comparison between groups after RT, total antioxidant capacity (TAC) decreased, total oxidant status (TOS) and oxidative stress index (OSI) increased, although the statistically significant change was only for OSI (p = 0.030). Addition of AMI or MEL to RT increased TAC and OSI significantly (p = 0.000), but there was no additive effect for TAC and OSI when both drugs were given together (p = 1.000, p = 0.172, respectively). In terms of TOS, statistically significant increasing was only for AMI (p = 0.000). There was protective effect when both drugs were given together against on Radiation-Induced Renal Oxidative Stress.Öğe CYCLIN D1 (A870G) GENE POLYMORPHISM IN LUNG CANCER(Elsevier Ireland Ltd, 2011) Cakina, S.; Gulyasar, T.; Sipahi, T.; Ozen, A.; Kocak, Z.[Abstract Not Available]Öğe EVALUATION OF BRCA 1-2 GENE MUTATIONS IN PATIENTS WITH TRIPLE NEGATIVE AND ER(-), PR(-), HER-2(+) BREAST CANCER(Elsevier Ireland Ltd, 2011) Uzal, M. C.; Sener, S.; Ozen, A.; Cakina, S.; Sipahi, T.; Cosar, R.; Gulyasar, T.[Abstract Not Available]Öğe GNB3 gene c.825C>T polymorphism and performance parameters in professional basketball players(Akademiai Kiado Zrt, 2014) Gulyasar, T.; Ozturk, L.; Sipahi, T.; Bayraktar, B.; Metin, G.; Yucesir, I.; Sut, N.This study has been conducted to determine whether mean values of peak oxygen consumption (VO2peak), anaerobic test parameters and knee isokinetic test measurements are different among guanine nucleotide-binding protein, beta-3 (GNB3) genotype groups in a group of basketball players. Methods: Seventy-two healthy male (mean age, 22.9 +/- 5.3 years) basketball players from the first division of national league participated. We studied GNB3 gene c. 825C>T (rs5443) polymorphism, then divided the subjects into three groups as CC (n = 21), CT (n = 35), and TT (n = 16). Mean VO2peak, Wingate anaerobic test results, and isokinetic knee muscle strength measurements were compared among the genotype groups. Results: Mean VO2peak (60.1 +/- 3.9; 56.7 +/- 3.6; and 57.8 +/- 3.3, respectively, p < 0.01), mean anaerobic minimum power (5.1 +/- 0.4; 5.3 +/- 0.5; and 4.4 +/- 0.5 W/kg, respectively, p < 0.001), mean anaerobic power drop (57.0 +/- 6.2; 54.2 +/- 6.9; and 62.9 +/- 5.3%, respectively, p < 0.001) were significantly different among the study groups, CC, CT, and TT. Individuals with TT genotype exerted lower performance in terms of isokinetic knee muscle strength. Conclusion: The presence of 825T-allele may impair athletic performance and may serve as a genetic marker of low capacity for athletic performance in male basketball players.Öğe Investigation of GSTM1 polymorphism genotypes and serum trace elements in colorectal cancer(Springer, 2015) Ay, A.; Alkanli, N.; Gulyasar, T.; Sipahi, T.; Cicin, I.[Abstract Not Available]Öğe Midkine Levels and its Relationship with Atherosclerotic Risk Factors in Essential Hypertensive Patients(Wolters Kluwer Medknow Publications, 2018) Guzel, S.; Cinemre, F. B. S.; Guzel, E. C.; Kucukyalcin, V.; Kiziler, A. R.; Cavusoglu, C.; Gulyasar, T.Background and Objectives: Hypertension (HT) is one of the risk factors associated with atherosclerosis. Midkine (MK) plays a role as a growth factor in various biologic and pathologic events. In some reports, MK expression has been shown to be linked with vascular smooth muscle proliferation and neo-angiogenesis in atherosclerotic vessels. The aim was to research relationship of MK serum levels with some atherosclerotic risk factors in hypertensive patients. Methodology: This study examined 60 patients with essential HT and 30 healthy controls. Serum biochemistry, including lipid profile, MK, Vitamin B 12, C-reactive protein, zinc and copper levels were obtained. Results: MK levels of the HT patients were significantly higher than the control group (24.8 +/- 6.8 ng/mL vs. 18.39 +/- 5.6 ng/mL, respectively, P < 0.01). Lipid profile parameters such as total cholesterol, triglyceride, low-density lipoprotein (LDL) were also significantly higher in HT patients (P < 0.021, P < 0.01, and P < 0.01, respectively). Zinc levels were 179.13 +/- 34.06 mu g/dL and 172.55 +/- 45.47 mu g/dL in the HT and control group, respectively. Serum MK levels were positively correlated with diastolic (r = 0.288, P < 0.05) and systolic blood pressures (r = 0.390, P < 0.002), and also with serum total cholesterol (r = 0.406, P < 0.002) and LDL cholesterol (r = 0.318, P < 0.015) levels. Furthermore MK was also negatively correlated with zinc and Vitamin B 12 levels (r = -0.298, P < 0.023, r = -0.334, P < 0.027, respectively). Conclusion: This study has demonstrated an important association between increased serum MK levels and risk factors of atherosclerosis such as HT, increased total and LDL cholesterol.