Yazar "Guercan, Saban" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim Yok
    Öğe
    CUTANEOUS INFECTION CAUSED BY ALTERNARIA ALTERNATA IN AN IMMUNOCOMPETENT HOST
    (Ankara Microbiology Soc, 2009) Guercan, Saban; Piskin, Sueleyman; Kilic, Haluk; Temelli, Baksel Ay; Yalcin, Oemer
    Human infections caused by Alternaria alternata are more frequently reported in immunosupressive hosts. In this report, a rarely seen cutaneous infection, caused by A.alternata in an immunocompetent patient was presented. The patient (71 years-old, male) was admitted to the dermatology unit with complaints of an erythematous and squamatous lesion of 5 cm diameter on left malleolar region. The case was evaluated as immunocompetent based on the normal serum total immunoglobulin and complement levels, anti-HIV negativity, and no known underlying disease. A number of Alternaria spp. conidia and hypha were seen in the microscopical examination of KOH treated cutaneous scrapings of the lesion obtained in two different days. Fungal cultures of the skin scrapings yielded the growth of a fungus identified as A.alternata. Although fungal elements were not detected in haematoxylene-eosin stained smears of the skin biopsy, A.alternato was again isolated in the culture of the biopsy specimen. The identification of the fungus was confirmed by a reference center (Mycology Section of Scientific Institute of Public Health, Belgium) and it was integrated to BCCM/IHEM collection under accession number IHEM 22598. Antifungal susceptibility test efforts failed due to a problem in the preparation of fungal suspension. Oral itraconazole (200 mg/day) and bifonazole cream was used for the treatment and the lesion regressed after the 19(th) day of the therapy. The treatment was continued with oral and local terbinafine for two weeks and the patient fully recovered. Since A.alternata was demonstrated both in the skin scrapings and tissue biopsy through microscopic examination and culture, it was evaluated as the causative agent of skin infection rather than colonization. This was the first A.alternato infection in an immunocompetent patient in the light of the current literature.
  • Küçük Resim Yok
    Öğe
    Investigation of tularemia seroprevalence in the rural area of Thrace region in Turkey
    (Ankara Microbiology Soc, 2007) Kilinc, Guenay Dedeoglu; Guercan, Saban; Eskiocak, Muzaffer; Kilic, Haluk; Kunduracilar, Hakan
    The first published tularemia epidemic in Turkey had been reported in 1936 from Luleburgaz (located in European part-Thrace region- of Turkey), and the second was in 1945 again in the same province. Following a long period of time without any tularemia report from Thrace region, in 2005 another epidemic occurred in a village of Edirne, another province located in the same region. Since there is presumptive evidence of circulation of the infectious agent, Francisella tularensis in Thrace region of Turkey, a large scale seroepidemiological study is needed. In this study, the presence of antibodies against F.tularensis in 1782 subjects, choosen by thirty cluster method, inhabiting in 90 different villages of Edirne, Kirklareli, and Tekirdag provinces in Thrace Region, were investigated. The subjects were included to the study on the basis of volunteering (74.3% were male; mean age: 46 years; age range: 6-92 years) and demographical characteristics and their possible risky behaviours were recorded in a questionnaire form. Antibodies specific for F.tularensis were screened by microagglutination test, and were found positive in five (0.3%) of the subjects between the titers of 1/20- 1/160. All of the seropositive subjects were adult males (ages between 22-74 years); three were living in the two villages of Kirklareli, while the others were from the villages of Tekirdag and Edirne. Rose Bengal test was also found positive in three of the seropositive subjects, and with the thought of a probable cross reaction they were taken into an advanced investigation for brucellosis. The risk evaluation revealed that male gender, being together with livestock and exposure to ticks were the major risk factors. Since the data of this study indicated that F.tularensis is in circulation in Thrace Region, the educational programmes for both the healthcare workers and inhabitants of this region should be attempted for the prevention of a possible epidemic.