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    Low sCD163/TWEAK Ratio at First Day After Acute Myocardial Infarction Associated with Adverse Cardiac Remodeling in Non-Elderly Patients
    (Russian Heart Failure Soc, 2022) Altintas, Mehmet Sait; Eyerci, Nilnur; Karayigit, Orhan; Demirtas, Bekir; Gok, Murat; Kiziltunc, Emrullah
    Aim In this study, we aimed to investigate the role of sCD163 /tumor necrosis factor-like weak apoptosisinducing (TWEAK) ratio in cardiac remodeling in non-elderly patients diagnosed with first acute myocardial infarction (MI). Material and Methods Forty-four patients (age ranges: 40-64 years) diagnosed with first-time acute ST-elevation MI in the emergency department were evaluated with cardiac magnetic resonance (CMR) imaging. Adverse remodeling (AR) was defined the increases of left ventricular end-diastolic volume by =12 % by CMR at 6-month post-MI TWEAK and sCD163 were measured at the first day (baseline), 2 weeks and 6 weeks post-MI. Results The average age of patients included in the study was 53.6 +/- 5.1 years. AR was detected in 18 patients at the 6 months post-MI. At the first day post-MI, median sCD163 concentration (116 069 vs 86 394 pg/ mL, p=0.040) and median TWEAK concentration (759.4 vs 220.1 pg /mL, p<0.001) were higher in AR group compared to group without AR (the non-AR group), median sCD163 /TWEAK ratio (101.4 vs. 406.8; p<0.001) was lower. At the first day post-MI, concentrations of TWEAK and sCD163 showed a positive correlation in AR group and group without AR s. At 2 weeks post-MI, positive correlation continued in the non-AR group, but no significant correlation was found in the AR group. At the first day post-MI, sCD163/TWEAK ratio was higher diagnostic performance compared to TWEAK and sCD163. Conclusion In the early phase post-MI, the relationship between sCD163 - TWEAK may have an important role in AR pathogenesis. A lower sCD163 /TWEAK ratio on the first day after MI was associated with an increase in left ventricular end-diastolic volume after 6 months of follow-up.
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    The Role of Interferons in Cardiac Remodeling after Acute Myocardial Infarction
    (Coll Physicians & Surgeons Pakistan, 2022) Eyyupkoca, Ferhat; Eyerci, Nilnur; Ozkan, Can; Kocak, Ajar; Gok, Murat; Ercan, Karabekir
    Objective: To determine the relationship of serial interferon (IFN) measurements and adverse cardiac remodeling (AR) after myocardial infarction (MI). Study Design: Observational multi-centre study. Place and Duration of Study: Departments of Cardiology of Diskapi Yildirim Beyazit Training and Research Hospital, Ataturk Training and Research Hospital, Numune Training and Research Hospital, and Dr. Nafiz Sincan Korez State Hospital, Turkey, from June 2015 to June 2020. Methodology: Forty-seven patients with acute MI were included. IFN levels were measured on the first day and at 14 days and 45 days post-MI. Reverse cardiac remodeling (RR) and AR were defined as the reduction of left ventricular end-diastolic volume by-12% and increases of-12% by cardiac magnetic resonance imaging at the 6-month follow-up. Statistical significance was accepted as p<0.05. Results: Median IFN-alpha (50.1 vs. 34.8 pg/mL, p=0.035), IFN-beta (39.1 vs. 23.0 pg/mL, p=0.013), and IFN-gamma (26.7 vs. 18.5 pg/mL, p=0.023) levels on the first day post-MI were higher in the AR group compared to the RR group. At 14 days post-MI, IFN levels had decreased in the AR group, while they had not changed in the RR group. At 45 days post-MI, IFN levels were similar between the AR and RR groups. High IFN-alpha level on the first-day post-MI was an independent predictor of AR (OR: 1.23, 95% CI: 1.06-1.43, p=0.008). Conclusion: High IFN levels in the acute phase post-MI are associated with AR. Among IFNs, IFN-alpha is an important predictor of AR. Stable IFN levels appear to be associated with cardiac healing.