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    The Effects of Licorice Root Powder (Glycyrrhriza glabra) on Performance, Serum Parameters, Egg Yolk Cholesterol and Antioxidant Capacity of Laying Japanese Quail
    (2018) Doğan, Sibel Canoğulları; Erdogan, Zeynep; Şekeroğlu, Ahmet; Baylan, Mikail; Küçükgül, Altuğ
    This study was conducted with the objectives to determine the effects of licorice rootpowder (Glycyrrhriza glabra) on performance, serum parameters, egg yolk cholesteroland antioxidant capacity in laying Japanese quail. Two hundred and forty 10-wk-oldJapanese quails were randomly assigned to four dietary groups, each one four timesreplicated with fifteen quails per dietary groups. Control group fed the basal diet; othergroups were fed basal diet supplemented with 0, 0.5, 1.0 and 1.5% licorice root powder.There were no significant differences in terms of final live weight, feed intake, feedconversion ratio, egg weight, serum cholesterol, triglyceride and High-DensityLipoprotein (HDL) concentration between treatment groups. Egg production was higherin control group and 0.5% licorice root powder supplemented groups. 1.0% licorice rootpowder supplemented group had lower egg production rate. Licorice root powdersupplementation decreased Low Density Lipoprotein (LDL) concentration and increasedglucose concentration significantly. Licorice root powder supplementation increased totalantioxidant status (TAS) and reduced total oxidant status (TOS) and oxidative stressindex (OSI). It was concluded from this study that supplementation of licorice rootpowder at the level of 0.5, 1.0 and 1.5% to the feed of laying quails had no adverseeffects on performance. Licorice root powder supplementation can be used to reducecholesterol level and increase antioxidant status in quails.
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    The Effects of Unsaturated Fatty Acid Supplementation to Ration on Superovulation Performance and Embryo Quality of Donor Cows
    (Galenos Publ House, 2021) Coban, Serdal; Erdogan, Zeynep
    This study was conducted to determine the effects of omega-3 (alinolenic acid) fatty acid supplementation to donor cow rations on superovulation performance, embryo number and quality, and blood-progesterone levels. The study was carried out with two groups, each consisting of 10 black-and-white breed dairy cows. Control group was fed with the basic ration prepared, and the experimental group was fed with the ration added with omega-3 polyunsaturated fatty acid (PUFA) source at a level of 3.82% of the basic ration dry matter (DM) for 60 days training period. Thus, each of experimental group's cow consumed 900 g-day feed additives consisting 149.4 g omega-3 daily. The superovulation protocol was started at the 40th day of feeding period. According to the findings of the study, the difference between the groups in terms of the response to superovulation was found to be insignificant (P>0.05). Similarly, there was no significant difference in blood progesterone levels between the groups (P>0.05). However, the difference between the control group and the experimental group in terms of transferable and non-transferable embryo rates was found to be significantly important (P<0.05). The total number of transferred embryos was determined as 37 in the experimental group and 79 in the control group. The total number of non-transferable embryos was recorded as 78 in the trial group and 43 in the control group. At the end of the study, it was concluded that supplementation to donor cow rations with omega-3 fatty acid sources might have a negative effects on transferrable embryo number and quality.
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    The natural flavonoid apigenin sensitizes human CD44+ prostate cancer stem cells to cisplatin therapy
    (Elsevier France-Editions Scientifiques Medicales Elsevier, 2017) Erdogan, Suat; Turkekul, Kader; Serttas, Riza; Erdogan, Zeynep
    Prostate cancer (PCa) is the second most common type of cancer and the fifth leading cause of cancerrelated death among men. Development of chemoresistance, tumor relapse and metastasis remain major barriers to effective treatment and all been identified to be associated with cancer stem cells (CSCs). Natural flavonoids such as apigenin have been shown to have the ability to improve the therapeutic efficacy of common chemotherapy agents through CSCs sensitization. Thus, the aim of this study was to evaluate the combination of apigenin with cisplatin on CD44(+) PCa stem cell growth and migration. Platinum-based anti-neoplastic drugs have been used to treat a number of malignancies including PCa. However, acquired resistance and side effects unfortunately have limited cisplatin's use. A CD44(+) subpopulation was isolated from human androgen-independent PC3 PCa cells by using human CD44-PE antibody. IC50 values were determined by MTT test. RT-qPCR, Western blot analyses and image-based cytometer were used to investigate apoptosis, cell cycle and their underlying molecular mechanisms. Cell migration was evaluated by wound healing test. The combination of the IC50 doses of apigenin (15 mu M) and cisplatin (7.5 mu M) for 48 h significantly enhanced cisplatin's cytotoxic and apoptotic effects through downregulation of Bcl-2, sharpin and survivin; and upregulation of caspase-8, Apaf-1 and p53 mRNA expression. The combined therapy suppressed the phosphorylation of p-PI3K and p-Akt, inhibited the protein expression of NF-kB, and downregulated the cell cycle by upregulating p21, as well as cyclin dependent kinases CDK-2, -4, and -6. Apigenin significantly increased the inhibitory effects of cisplatin on cell migration via downregulation of Snail expression. In conclusion, our study showed the possible therapeutic approach of using apigenin to potentially increase the effects of cisplatin by targeting CSCs subset in prostate cancer. (C) 2017 Elsevier Masson SAS. All rights reserved.
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    PERFORMANCE, EGG QUALITY AND SERUM PARAMETERS OF JAPANESE QUAILS FED DIET SUPPLEMENTED WITH SPIRULINA PLATENSIS
    (Parlar Scientific Publications (P S P), 2016) Dogan, Sibel Canogullari; Baylan, Mikail; Erdogan, Zeynep; Akpinar, Gulsen Copur; Kucukgul, Altug; Duzguner, Vesile
    This experiment was conducted to evaluate the influence of Spirulina platensis on growth performance, egg quality and some serum parameters of laying Japanese quails. For this experiment, 100 ten weeks-old, female Japanese quails (Coturnix coturnix Japonica) with similar body weight were caged individually and were randomly divided into four groups of 25 quails each. Quails were fed diets supplemented with 0 (control), 0.5, 1.0 and 2.0% Spirulina platensis for 8 weeks. Spirulina platensis addition did not affect feed conversion ratio, feed intake, egg production, egg weight, shape index, eggshell thickness and haugh unit, significantly (P>0.05). However, there were significant differences (P<0.05) in final body weight, yolk index, albumen index and eggshell weight of experimental groups. There were significant differences (P<0.05) between groups in low density lipoprotein (LDL cholesterol) and high density lipoprotein (HDL cholesterol) concentrations. The LDL cholesterol concentration decreased while HDL cholesterol concentration increased with the increased supplementation of Spirulina platensis. Spirulina platensis supplementation also decreased plasma total cholesterol and trigyliceride levels between groups numerically but not statistically (P>0.05). The mean egg yolk cholesterol levels dropped by 19.65 and 18.93% in the 1.0 or 2.0% Spirulina platensis supplemented groups compared with control group. In conclusion, Spirulina algae can be used safely in laying quails diets with important effects on serum parameters and egg yolk cholesterol.