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Öğe Comparative Investigation of Anti-Inflammatory Effect of Platelet-Rich Fibrin after Mandibular Wisdom Tooth Surgery: A Randomized Controlled Study(Mdpi, 2023) Karaca, Gamze Tanan; Duygu, Gonca; Er, Nilay; Ozgun, ErayThis study evaluated the anti-inflammatory effect of platelet-rich fibrin (PRF) applied to the extraction socket after impacted mandibular third molar surgery with subjective and objective parameters. Forty-eight patients with impacted wisdom teeth in bilateral and similar positions were included in the study. The control group was formed with the standard surgery and the PRF group was formed with local PRF application in addition to standard procedure (n = 96). The anti-inflammatory activity of PRF on postoperative 2nd and 7th days was evaluated subjectively by clinical parameters and objectively by biochemical parameters. Postoperative 2nd- and 7th-day follow-up data of pain, edema, and trismus in the PRF group were found to be statistically significantly lower. Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were found to be statistically significantly lower in the PRF group than the control in the postoperative 2nd-day follow-up period (p < 0.001). There was no statistically significant difference in interleukin 6 (IL-6) and tumor necrosis factor-alpha (TNF-& alpha;) parameters when the PRF group and the control group were compared in both follow-up periods (p > 0.05). The study has demonstrated the effectiveness of locally applied PRF after ITM surgery via clinical parameters and objective data. The quantitative analysis of CRP and ERS can be an effective parameter in determining the amount of inflammation after ITM surgery.Öğe Does Saline Irrigation at Different Temperatures Affect Pain, Edema, and Trismus After Impacted Third Molar Surgery: A Clinical Trial(W B Saunders Co-Elsevier Inc, 2023) Canakci, F. Gulfesan; Er, Nilay; Duygu, Gonca; Karaca, Gamze TananPurpose: Lower impacted third molar surgery is a very common oral-maxillofacial surgical procedure, which has complications such as facial swelling, pain, and trismus. This clinical trial aimed to compare the intensity of postoperative morbidity (pain, facial swelling, and trismus) following the third molar surgery performed using saline irrigation at different temperatures (4 degrees C, 10 degrees C, or 25 degrees C).Materials and Methods: This double-blind, single-center, split-mouth, randomized prospective clinical trial was conducted among 48 systemically and periodontally healthy patients who had bilaterally asymp-tomatic mandibular third molars. Patients were randomly allocated into 2 groups (n = 24) according to the temperature of the saline used. In each patient, one impacted third molar was determined as the test group (4 degrees C or 10 degrees C saline irrigation) and the other impacted third molar as the control group (25 degrees C saline irri-gation). Trismus and swelling were evaluated on the 1st, 3rd, and 7th days postoperatively. Pain perception by visual analog scale (VAS) and the total number of analgesics taken during the 7 postoperative days were recorded. Data were analyzed using the Shapiro-Wilk test, the chi-square test, one-way analysis of variance, Duncan test, the Kruskal-Wallis test, the Dunn test, and the Friedman test (P < .05).Results: Forty-eight patients (28 females, 20 males) with a mean age of 24.6 +/- 3.8 years were included in the study. The duration of operations was similar. VAS values of test groups [test group 1 (4 degrees C): 4.0, test group 1 (10 degrees C): 8.0] and the number of analgesics taken [test group 1 (4 degrees C): 0, test group 1 (10 degrees) C): 3] were significantly lower (P < .001) than control groups (VAS, control group 1: 13.0, control group 2: 15.5, number of analgesic taken, control group 1: 5.5, control group 2: 4.0). Significant differences were found between the test groups in VAS values and the number of analgesics taken (P < .001). Also, the lowest trismus and facial swelling values were detected in the 4 degrees C test group at all time points (P < .001). Conclusion: In the impacted third molar surgery, the use of cooled saline irrigation during bone removal may be a simple, inexpensive, and effective method for reducing early postoperative complaints. (c) 2022 American Association of Oral and Maxillofacial SurgeonsÖğe Efficacy of platelet rich fibrin in the reduction of the pain and swelling after impacted third molar surgery: Randomized multicenter split-mouth clinical trial(Biomed Central Ltd, 2015) Ozgul, Ozkan; Senses, Fatma; Er, Nilay; Tekin, Umut; Tuz, Hakan Hifzi; Alkan, Alper; Kocyigit, Ismail DorukBackground: Impacted third molar removal is a routine procedure in oral and maxillofacial surgery. Platelet-rich fibrin (PRF) is a second generation platelet concentration which is produced by simplified protocol. The aim of this study was to assess the effectiveness of PRF in the healing process by evaluating the changes in pain and swelling after third molar surgery. Methods: Fifty-six patients (23 male, 33 female) who provide the inclusion criteria were selected to participate in this study. The evaluation of the facial swelling was performed by using a horizontal and vertical guide. The pain was evaluated in the postoperative period using a visual analog scale (VAS) of 100 mm. Results: Horizontal and vertical measurements showed more swelling at the control side (without PRF) in 3th day postoperatively (p < 0.05). There were no statistically significant differences regarding pain among the groups. Conclusion: As a conclusion, PRF seems to be effectiveness on postoperative horizontal swelling after third molar surgery. PRF could be used on a routine basis after third molar extraction surgery.Öğe Improved Dental Implant Drill Durability and Performance Using Heat and Wear Resistant Protective Coatings(Allen Press Inc, 2018) Er, Nilay; Alkan, Alper; Ilday, Serim; Bengu, ErmanThe dental implant drilling procedure is an essential step for implant surgery, and frictional heat in bone during drilling is a key factor affecting the success of an implant. The aim of this study was to increase the dental implant drill lifetime and performance by using heat- and wear-resistant protective coatings to decrease the alveolar bone temperature caused by the dental implant drilling procedure. Commercially obtained stainless steel drills were coated with titanium aluminum nitride, diamond-like carbon, titanium boron nitride, and boron nitride coatings via magnetron-sputter deposition. Drilling was performed on bovine femoral cortical bone under the conditions mimicking clinical practice. Tests were performed under water-assisted cooling and under the conditions when no cooling was applied. Coated drill performances and durabilities were compared with those of three commonly used commercial drills with surfaces made from zirconia, black diamond. and stainless steel. Protective coatings with boron nitride, titanium boron nitride, and diamond-like carbon have significantly improved drill performance and durability. In particular, boron nitride-coated drills have performed within safe bone temperature limits for 50 drillings even when no cooling is applied. Titanium aluminium nitride coated drills did not show any improvement over commercially obtained stainless steel drills. Surface modification using heat-and wear-resistant coatings is an easy and highly effective way to improve implant drill performance and durability, which can improve the surgical procedure and the postsurgical healing period. The noteworthy success of different types of coatings is novel and likely to be applicable to various other medical systems.Öğe İNTERNETTEN SATIN ALINAN SİGARA BIRAKTIRMA İLACI KULLANIMI İLE OLUŞAN ‘KİSSİNG LEZYON’ GÖRÜNÜMLÜ KİMYASAL İRRİTASYON: VAKA RAPORU(2015) Ocak, Hakan; Er, Nilay; Etöz, Osman A.; Alkan, AlperMedian romboid glossit (MRG) dilin dorsalyüzeyinde posterior bölgede oluşan papiller atrofi olarak tanımlanır. MRG simetrik olarak palatal lezyonlar ile ilişkili olduğunda bu durum ''kissing lezyon'' olarak tanımlanır ve bu hastalarda immünsüpresyon ve insan bağışıklık yetmezlik virüsü (HIV) düşünülmelidir. Internet sitesinden satın alınan sigara bıraktırma ürünü kullanımı ile oluşan kissing lezyon görünümünde mukozal irritasyon vakası sunulmuştur. Özellikle palatal lezyonlar ilk bakışta malignite şüphesi uyandırsa da özenli tıbbi anamnez ve klinik değerlendirme ile predispozan faktör saptanmıştır. Bu tür lezyonlar ile karşılaşıldığında, hekimler ağız kavitesinde ilaç emiliminin benzer durumlara neden olabildiğini saklayabileceği düşüncesi ile ayrıntılı anamnez alınması gerektiğini akılda tutmalıdır. Aksi takdirde hastaya gereksiz yere pek çok teşhis yöntemi uygulanabilirÖğe Preventive effect of doxycycline sponge against bisphosphonate-related osteonecrosis of the jaws: an animal study(Taylor & Francis Ltd, 2016) Capar, Gonca Duygu; Sapmaz-Metin, Melike; Kutan, Esma; Tomruk, Ceyda Ozcakir; Yalcin, Gul Merve; Er, Nilay; Ozfidan, Gulnur KizilayThe aim of this study is to investigate the effect of doxycycline collagen sponge on bisphosphonate-related osteonecrosis of the jaw (BRONJ) and the level of serum biomarkers as an indicator of osteonecrosis. Twenty-four rats were divided into four groups. Animals in the control group were injected with saline and animals in Groups I, II and III were injected with zoledronate three times a week for eight weeks. After eight weeks, the following procedures were performed in each group. In Group I: extraction of maxillary first molar, in Group II: extraction of maxillary first molar and mucoperiosteal coverage was performed and in Group III: extraction of maxillary first molar and mucoperiosteal coverage with doxycycline collagen sponges was performed. At the end of 16 weeks, all animals were sacrificed. Serum collagen type I C-telopeptide (CTx), tartrate-resistant acid phosphatase (TRACP 5b) and alkaline phosphatase (ALP) levels' analysis, clinical examination, histological and histomorphometrical analysis were performed. As a result no significant difference in CTx, TRACP 5b and ALP levels was observed between groups. Complete mucosal healing was observed in all animals in the control group and 66.7% of animals in Group III. The necrotic bone area in Group III was significantly lower than the other groups (p < 0.01). Statistically significant difference was observed between groups in terms of detached osteoclast number (p < 0.01). In conclusion, local application of doxycycline could have a positive effect in reducing the risk of BRONJ in rats.Öğe Removal of a supernumerary tooth displaced into the infratemporal fossa during extraction(Istanbul Univ Press, Istanbul Univ Rectorate, 2018) Yucesoy, Turker; Ocak, Hakan; Er, Nilay; Alkan, AlperAccidental displacement of an impacted tooth into the infratemporal fossa (ITF) is a rare but serious complication because of the vulnerability of the surrounding anatomical structures. Here we present the case of a 40-year-old man who reported pain on the right side of his face. Panoramic radiography and cone-beam computed tomography revealed an impacted third molar and a supernumerary tooth positioned immediately below it. Under local anesthesia, the third molar was easily extracted; however, the supernumerary tooth was inadvertently displaced into the ITF. The position of the tooth was confirmed by radiographic examination, and it was immediately removed intraorally by expanding the flap and carefully dissecting the soft tissues. Clinical aspects of this rare complication were evaluated, with special emphasis on the reliability of imaging modalities and surgical techniques.Öğe Surgical management of stage-2 medication-related osteonecrosis of the jaw with transplantation of human amniotic membrane: Preliminary results(Elsevier, 2022) Canakci, F. GulfeSan; Er, Nilay; Duygu, Gonca; Varol, G. F. UsunMedication-related osteonecrosis of the jaw (MRONJ) is a drug adverse reaction. Seven osteonecrosis areas in 5 cases were treated with stage-2 MRONJ using human amniotic membrane (HAM) transplantation after sequestrectomy. Patients were evaluated in terms of infection (pain, erythema, and pus), mucosal coverage, and pain at 1, 2, 4, 8, and 12 weeks. Patients who showed improvement (total mucosal coverage, no sign of infection and pain) at the end of 12 weeks were followed up every 8 weeks. Also, radiographic examinations (panoramic radiography at every 8 weeks, cone-beam computed tomography at every 6 months) were performed to evaluate bone destruction. Complete mucosal closure was achieved in 6 necrosis sites. In only 1 patient, mucosal coverage was not achieved. No pain and infection relapse were observed during the followups. HAM might be an effective material in terms of soft tissue healing and elimination of pain and infection for stage-2 MRONJ. Clinical Trials Registration Number: NCT04967963 (C) 2021 Published by Elsevier Masson SAS.Öğe Temporomandibular joint arthrocentesis videos on YouTube: Are they a good source of information?(Elsevier, 2022) Er, Nilay; Canakci, F. GulfesanBackground: YouTube has been increasingly used as a source of information by patients in the field of health, but many studies revealed poor information quality. This study evaluated the content and quality of YouTube videos on Temporomandibular Joint Arthrocentesis (TMJA) as an information resource for patients. Material and methods: YouTube search with the two keywords temporomandibular joint arthrocentesis and temporomandibular joint lavage was performed. The first 160 videos were listed for each term according to relevancy.Results were assessed for inclusion and categorized for source, purpose, target, arthrocentesis method described, and the narrator of the videos. An evaluation was performed independently by two oral and maxillofacial surgeons. The quality of videos was analyzed for the content and defined as poor, moderate, and excellent. DISCERN was also performed by scoring between 0 and 5. Results: A total of 43 videos were evaluated. The most upload source was individual users (46.5%) and the most video upload purpose was information for professionals (37.2%). The method with the most information about was the two-needle technic, which had a rate of 44.2 percent. The average usefulness score of the vid-eos was 3.00 and 57.1% of the videos resulted in poor quality. A statistically significant positive high correla-tion was found between DISCERN and usefulness scoring (r = 0.793; p < 0.001).Conclusion: The majority of YouTube videos are of poor quality and this situation affects the patients' deci-sions about treatment. Health professionals should be aware of the content on YouTube and produce high -quality, accurate, and up-to-date information for patient education.(c) 2022 Elsevier Masson SAS. All rights reserved.