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    Analysis of various potential prognostic markers and survival data in clear cell renal cell carcinoma
    (Brazilian Soc Urol, 2017) Ebru, Tastekin; Fulya, Oz Puyan; Hakan, Akdere; Vuslat, Yurut-Caloglu; Necdet, Sut; Nuray, Can; Filiz, Ozyilmaz
    Purpose: Clear cell renal cell cancers frequently harbor Von Hippel-Lindau gene mutations, leading to stabilization of the hypoxia-inducible factors (HIFs) and their target genes. In this study, we investigated the relationship between vascular endothelial growth factor (VEGF), HIF-1 alpha, HIF-2 alpha, p53 positivity, microvessel density, and Ki-67 rates with prognostic histopathologic factors (Fuhrman nuclear grade, stage, and sarcomatoid differentiation) and survival in clear cell renal cell carcinomas. Material and Methods: Seventy-two nephrectomy specimens diagnosed as clear cell renal cell carcinoma between 2000 and 2012 were reevaluated. Immunohistochemically VEGF, HIF-1 alpha, HIF-2 alpha, p53, CD34 (for microvessel density evaluation), and Ki-67 antibodies were applied to the tumor areas. The relationships of these antibodies with prognostic factors and survival rates were evaluated with statistical analyses. Results: Mean survival time was 105.6 months in patients with ccRCC. Patients with high expression of VEGF, HIF-1 alpha and HIF-2 alpha positivity, a high Ki-67 proliferation index, and a high microvessel density evaluation score had a shorter survival time (p<0.05). Conclusions: Our findings supported that with the use of these immunohistochemical markers, prognosis of renal cell carcinoma may be predicted at the first step of patient management. New treatment modalities targeted to HIF-1 alpha and HIF-2 alpha might be planned as well as VEGF-targeted therapies in the management of clear cell renal cell carcinomas.
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    Primary mucinous adenocarcinoma of the larynx in female patient: a rare entity
    (Elsevier Science Inc, 2012) Ebru, Tastekin; Omer, Yalcin; Fulya, Oz Puyan; Ufuk, Usta; Kemal, Kutlu
    Laryngeal malignant tumors are mainly composed of squamous cell carcinomas. Glandular carcinomas of the larynx are rare tumors that constitute less than 1% of all laryngeal malignancies where adenocarcinoma not otherwise specified is the most common histologic subtype. Here we report a case of a 70-year-old female patient with primary laryngeal mucinous adenocarcinoma. The rarity of the tumor type and the differential diagnosis of this tumor before reporting it as a primary adenocarcinoma of the larynx are discussed here with literature findings. (C) 2012 Elsevier Inc. All rights reserved.
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    SARCOMATOID CARCINOMA AND MALIGNANT PERIPHERAL NERVE SHEATH TUMOUR IN LUNG: TWO CASE REPORTS, IMPORTANCE OF CLINICOPATHOLOGIC CORRELATION
    (Wiley-Blackwell, 2014) Ebru, Tastekin; Inci, Kutlu; Erhan, Isler; Nuray, Can; Kemal, Kutlu
    [Abstract Not Available]