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    THE PROTECTIVE EFFECT OF MOCLOBEMIDE AGAINST HYPOXIA-INDUCED LETHALITY IN MICE IS NOT DUE TO A DECREASE IN BODY-TEMPERATURE
    (Pergamon-Elsevier Science Ltd, 1995) ULUGOL, A; KARADAG, HC; DOKMECI, D; ALKHATIB, I; DOKMECI, I
    The protective effect of moclobemide, a reversible and highly selective inhibitor of monoamine oxidase-A, against hypoxia-induced lethality was investigated in the present experiment. Moclobemide showed an apparent protective potency against hypoxia and significantly prolonged the latencies for convulsions and death in a dose-dependent manner. Hypothermia is known to protect animals from hypoxia. Moclobemide also decreased body temperature in mice; however, the hypothermic effect was unrelated to the antihypoxic effect. These results suggest that the protective effect of moclobemide in hypoxia is not due to a decrease in body temperature.