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Öğe Association of selenoprotein W1 (rs3786777) polymorphism, maternal plasma selenoprotein W (SelW), and selenium levels in patients with pre-eclampsia(Dustri-Verlag Dr Karl Feistle, 2019) Cinemre, Fatma Behice Serinkan; Cinemre, Hakan; Erdogan, Elif; Dilaveroglu, Nilgun; Tuten, Abdullah; Kaya, Baris; Yilmaz, NevinObjective: To investigate the role of selenoprotein W1 (SEPW1) single nucleotide polymorphism (SNP) in etiopathogenesis of pre-eclampsia (PE) and its association with maternal selenoprotein W (SelW) and selenium levels. Materials and methods: In this study, 98 pregnant women who were diagnosed with PE and 100 healthy pregnant controls were investigated. To identify the polymorphism of the SEPW1 gene (rs3786777), allele-specific polymerase chain reaction (ASPCR) analysis was used. Serum selenium levels and plasma SelW levels were measured by graphite-furnace atomic absorption spectrophotometry and by ELISA, respectively. Results: Maternal selenium levels (mu g/L) were 92.56 +/- 6.10 and 86.26 +/- 6.33 in pregnant women with and without PE, respectively (p > 0.05). On the other hand, SelW levels (ng/mL) were significantly lower in PE (72.08 +/- 8.10) compared to controls (89.29 +/- 6.99) (p < 0.01). The frequencies of the CC, CA, and AA genotypes were found to be 26%, 61%, and 13% in pregnant women with PE and 28%, 55%, and 17% in healthy pregnant controls. The distribution of the SEPW1 genotypes and alleles did not differ significantly among subjects with and without PE. In PE patients, SelW levels were lower in CC and CA genotypes compared to controls (p < 0.05 and p < 0.001). Conclusion: SEPW1 gene polymorphism did not seem to affect risk of PE in our population. However, SelW levels were low in some genotypes of the gene, suggesting that SelW might have played a role in the etiopathogenesis of PE.Öğe The Role of Maternal Oxidative Stress, Iron/Zinc, Copper/Zinc Ratios and Trace Element Levels in the Pathogenesis of Preeclampsia(2017) Cinemre, Fatma Behice Serinkan; Cinemre, Hakan; Kartal, Nagihan; Gülyaşar, Tevfik; Yıldız, Mustafa; Tüten, Abdullah; Yılmaz, NevinPurpose:Preeclampsia (PE) is a complex disease and the underlying mechanisms are not known, yet. It is well known that oxidative stress and trace elements play a role in the pathogenesis of various diseases. Several studies have shown that the levels and proportions of trace elements are closely related to the severity of the disease. The aim of the study was to investigate the changes in some characteristics parameters, serum zinc, iron, copper levels, and copper/zinc and iron/zinc ratios and plasma lipid peroxidation levels in patients with mild and severe preeclampsiaÖğe The role of selenoprotein P and selenium in the etiopathogenesis of gestational diabetes mellitus: Association with selenoprotein P1 gene (rs3877899) polymorphism(Dustri-Verlag Dr Karl Feistle, 2018) Cinemre, F. Behice Serinkan; Cinemre, Hakan; Yucel, Ayse; Degirmencioglu, Sevgin; Tuten, Abdullah; Yuksel, M. Aytac; Yilmaz, NevinObjective: The aim of this study was to investigate the role of selenoprotein P (SeP) and selenium in the etiopathogenesis of gestational diabetes mellitus (GDM) and their association with a common selenoprotein P1 (rs3877899) single nucleotide polymorphism (SNP) in pregnant women with GDM. Materials and methods: Eighty-six pregnant women with GDM and 90 healthy pregnant women from the same geographic region were included in the study. Fasting glucose, insulin HOMA-IR, and HbA1c were compared. Serum selenium levels were measured by graphite-furnace atomic absorption spectrophotometer. Plasma SeP levels were determined by ELISA. Allele-specific polymerase chain reaction (ASPCR) analysis was used to identify polymorphisms of the selenoprotein P1 gene (SEPP1) (rs3877899). Results: The biochemical parameters of GDM such as fasting glucose, insulin, HOMA-IR, and HbA1c were higher in pregnant women with GDM compared to healthy pregnant women. Maternal selenium levels (mu g/L) were 77.99 +/- 7.21 and 76.04 +/- 7.77 in GDM and healthy pregnant women, respectively (p > 0.05). However, SeP levels (ng/mL) were found to be significantly lower in GDM (35.29 +/- 3.00) compared to control subjects (46.98 +/- 4.59) (p < 0.01). Although there was no significant difference in the distribution of the SEPP1 genotypes and alleles between two groups, SeP levels were higher in the GG genotype of the gene compared to their respective control (p < 0.001). Conclusion: Although frequency of SEPP1 polymorphism and selenium levels did not differ significantly between diabetic and healthy pregnant women, SeP levels increased in pregnant women with GDM suggesting SeP plays a role in the etiopathogenesis of GDM. Moreover, the GG genotype of SEPP1 gene polymorphism may be involved in the development of GDM with a different mechanism. It should be clarified with further studies in larger populations.Öğe Roles of selenoprotein K and selenium status in the etiopathogenesis of preeclampsia: Their relationships with maternal lipid peroxidation, oxidative DNA damage, and glutathione peroxidase(Dustri-Verlag Dr Karl Feistle, 2018) Cinemre, Fatma Behice Serinkan; Aydemir, Birsen; Gulyasar, Tevfik; Cinemre, Hakan; Tuten, Abdullah; Yolmaz, Nevin; Yoldoz, MustafaObjective: Preeclampsia (PE) is a complex disease and the underlying mechanisms are not known yet. It is well known that selenium and oxidative stress play a role in the pathogenesis of various diseases as well as PE. The aim of the study was to investigate the changes in selenium status, as an essential trace element, and selenoprotein K (SelK), a newly described selenoprotein which has been suggested to have an antioxidant function in some tissues in patients with preeclampsia. We also aimed at investigating their relationships with maternal lipid peroxidation, oxidative DNA damage, and glutathione peroxidase (GPx) activities. Materials and methods: 38 healthy pregnant and 48 pregnant women with PE were included in the study. Serum selenium levels were measured by graphite-furnace atomic absorption spectrophotometry. Plasma TBARS levels were analyzed by spectrophotometric method; GPx activities, 8OHdG, and SelK levels were determined by ELISA. Results: Plasma TBARS and 8OHdG levels were found to be increased in the PE group compared to the healthy pregnant group. Plasma SelK levels and GPx activities were found to be lower in the PE group than in the healthy control group. However, there was no significant difference in serum selenium levels between two groups. Furthermore, a significant correlation was determined between plasma SelK levels and GPx activities in PE patients group (r = 0.743; p < 0.01). Likewise, a significant positive correlation was found between plasma 8OHdG and TBARS levels (r = 0.457; p < 0.01), serum selenium levels and plasma GPx activities (r = 0.663; p < 0.01), serum selenium and plasma SelK levels (r = 0.851; p < 0.01) in PE. Conclusion: Our findings indicated that a selenoprotein SelK and a selenoenzyme GPx play a role in the etiopathogenesis of PE. Decreases in these antioxidant systems were associated with increase in lipid and DNA oxidation in PE patients. Underlying mechanisms of SelK and its interactions with selenium status and GPx in PE should be clarified in details with further studies.Öğe THYROID DYSFUNCTIONS DUE TO LITHIUM TREATMENT IN BIPOLAR DISORDER: CHANGES IN OXIDATIVE STRESS, TRACE ELEMENTS, AND HEMORHEOLOGICAL PARAMETERS(Polish Society Magnesium Research, 2020) Bahtiyar, Nurten; Cinemre, Fatma Behice Serinkan; Cinemre, Hakan; Kiziler, Ali Riza; Atagun, Murat Ilhan; Gulyasar, Tevfik; Aydemir, BirsenLithium is one of the most widely used medications for the treatment of bipolar disorder (BD). It also has some side effects on thyroid functions. We aimed to investigate the role of oxidative stress, trace elements, and hemorheological parameters on the pathophysiology of thyroid dysfunctions developed by lithium treatment in patients with BD. Patients with BD were divided into three groups: patients that non-lithium-treated, lithium-treated patients for 4-6 weeks, and lithium-treated patients for 40-68 weeks. Blood samples for analysis were taken before and after the treatment period. After analysis, patients were divided into six groups: non-treatment BD group (Group 1); short-term lithium-treatment group that did not develop thyroid dysfunctions (Group 2); short-term lithium-treatment group that developed hyperthyroidism (Group 3); long-term lithium treatment group that developed hypothyroidism (Group 4), long-term lithium-treatment group that developed hyperthyroidism (Group 5), and long-term lithium-treatment group that did not develop thyroid dysfunctions (Group 6). Plasma and whole blood viscosity levels were significantly increased in Groups 4 and 6 compared to Groups 1, 2, and 3. Hemoglobin levels were lower in Group 4 than in Groups 1, 2, and 5. Fibrinogen values were higher in Groups 4 and 5 than Group 1. Plasma and erythrocyte malondialdehyde levels were higher in Group 4 than In Groups 1, 2, 3, and 5. Also, they were increased in Group 6 in comparison with Groups 2 and 3. Erythrocyte glutathione levels were lower in Groups 4 and 6 than Groups 1, 2, 3 and 5. Plasma protein carbonyls levels were higher in Group 4 than in Group 1, or in Group 5 than in Groups 1, 2, and 3, as well as in Group 6 than Groups 1, and 2. Serum zinc levels were higher in Groups 2, 3 and 6 than in Group1. Serum copper levels increased in Groups 2, 4 and 6 in comparison with Group1. The results of this study indicate that oxidative stress increased with treatment time in lithium-induced thyroid dysfunctions. Also, whole blood viscosity, plasma viscosity, fibrinogen, zinc, and copper levels were affected by lithium treatment and treatment duration induced thyroid dysfunctions.
