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    Effect Mechanism Of Immunosupressive Drugs
    (Pera Yayincilik Hizmetleri, 2009) Ayna, Tulay Kilicaslan; Ciftci, Hayriye Senturk; Tozkir, Hilmi; Gurtekin, Mehmet; Carin, Mahmut
    Effective immunosuppression is a key to successful organ transplantation. This study will provide an overview of different immunosuppressive agents used in solid organ transplantation. An increasing number of immunosuppressive agents are available and these agents target different steps of the immunological response to an allograft. These immunosuppressive agents are steroids, anti- proliferative agents (azathioprine and mycophenolate), calcineurin inhibitors (cyclosporine and tacrolimus), TOR inhibitors (sirolimus and everolimus), polyclonal and monoclonal antibody preparations.
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    Positive Mixed lymphocyte Culture Test Result Due to HLA-DP Mismatch
    (Galenos Publ House, 2011) Ayna, Tulay Kilicaslan; Tozkir, Hilmi; Ciftci, Hayriye Senturk; Gurkan, Hakan; Tekgunduz, Emre; Algunes, Cetin; Gurtekin, Mehmet
    Graft Versus Host Disease (GVHD) remains a major cause of morbidity and mortality in allogeneic stem cell transplantation (SCT). The MLC assay has been generally accepted as a standard test for determining HLA-D region compatibility. In this study, the MLC test has been carried out on the related recipient-donor couple who were prepared for allogeneic SCT and were found to be matched for HLA-A, -B, -Cw, DR, DO but not for -DP. The result of the MLC test was positive. We observed that HLA-DP mismatch was responsible for the increased proliferation values in MLC test.