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    Effect of Ginkgo biloba extract (EGb 761) on the healing of left colonic anastomoses in rat
    (Wiley, 2007) Kisli, Erol; Ozdemir, Huelya; Kosem, Mustafa; Surer, Hatice; Ciftci, Ali; Kanter, Mehmet
    Background The aim of this study was to assess the effect of Ginkgo biloba extract (EGb 761) on healing of experimental colonic anastomoses in a rat model. Methods Rats were divided into four groups: postoperative day (POD) 3 untreated control group, POD 3 EGb 761 group, POD 7 untreated control group, and POD 7 EGb 761 group. In the oral EGb 761 groups, the agent was given at 9.6 mg daily per orogastric route using a 4-F fine feeding catheter. We measured bursting pressures and hydroxyproline content and histologically examined the resected anastomoses on POD 3 and POD 7. Results The bursting pressures increased more in the EGb 761 group than in the untreated control group on POD 3, but this difference was not statistically significant. Hydroxyproline content was higher in the EGb 761 group than in the untreated control group on POD 3, and this difference was statistically significant. Anastomosis bursting pressure values and hydroxyproline contents were significantly higher in the EGb 761 group than in the untreated control group on POD 7. Histological examination showed greater fibroblastic activity in the EGb 761 group than in the untreated control group on POD 3. There was no significant difference in anastomotic polimorphonuclear leukocyte, mononuclear cells and blood vessel neodevelopment between the POD 3 groups, but there was significant difference in fibroblastic activity and blood vessel neodevelopment between the POD 7 groups. Conclusions These results showed us that EGb 761 administration resulted in enhanced stability of colonic anastomoses during the first postoperative week.
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    Hepatic hydatid disease in children and adults living in different areas in Turkey
    (Saudi Med J, 2007) Inan, Mustafa; Ayvaz, Suleyman; Baser, Murat; Karaayvaz, Muammer; Ciftci, Ali; Hatipoglu, Ahmet R.; Gul, Hatice
    Objective: To compare the clinical features of the hepatic hydatid disease in the operated children and adults living in the east and west part of Turkey. Methods: Between January 2001 and May 2005, 105 patients were operated with the diagnosis of hepatic hydatid cyst in Trakya and Yuzuncu Yil University Hospitals, Turkey. The patients (n=105) were retrospectively evaluated in 4 groups; Edirne Ch: (18 children under 18 year-old) and Edirne Ad: (20 adults) were from Edirne, Van Ch: (22 children under 18 year-old) and Van Ad: (44 adults) from Van. The patients in each group were analyzed according to their clinical and radiological findings. Results: The frequency of hepatic hydatid cysts in children was significantly higher in boys in Edirne Ch group and in girls in Van Ch group (p<0.05). In adults, the disease was also seen significantly higher in males in Edirne Ad group and females in Van Ad group (P<0.05). There were no difference symptoms of the disease, concomitant extra hepatic cysts and total cyst number in children and adults in the same region (p>0.05). The number of huge hepatic cysts and history of contact with animal were more common in children and adults living in Van. Conclusion: While the course of hepatic hydatid disease has the similar clinical features among the children and adults in the same region, remarkable regional differences have been found on it.