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    THE EFFECT OF WARFARIN ON SURVIVAL IN PATIENTS WITH LUNG CANCER
    (Lippincott Williams & Wilkins, 2012) Ciftci, Abdullah; Altiay, Gundeniz
    [Abstract Not Available]
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    Pulmonary involvement in brucellosis
    (Aves Yayincilik, Ibrahim Kara, 2007) Batmaz, Emrah; Edis, Ebru Cakir; Ciftci, Abdullah; Akkoyun, Sevin; Hatipoglu, Osman N.; Genchallac, Hakan
    Brucellosis is a zoonotic disease caused by a Gramnegative bacillus of the Brucella gender. Involvement is multisystemic primarily affecting the reticuloendothelial system, joints,heart, and kidneys. Although the disease can be spread by inhalation, pulmonary involvement is rare. A 72-year-old female patient presented with complaints of chest pain and shortness of breath. She was admitted with a preliminary diagnosis of pneumonia. She did not respond to antibiotic therapy. Computed tomography performed for the differential diagnosis of pulmonary embolism showed no evidence for thrombus, but ground glass opacities in the lingular segment of the left lung, the right middle lobe, and bilateral lower lobes. Specific antibiotic therapy Was started upon detection of Brucella spp. by hemoculture. The patient's pain disappeared and no sign of venous thromboembolism was observed.
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    A Rare Cause of Hemoptysis
    (Aves, 2009) Ciftci, Abdullah; Ozdemir, Levent; Hatipoglu, Osman Nuri; Caglar, Tuncay
    Hemoptysis is a bleeding in the respiratory system together with a cough. Common causes of hemoptysis are bronchitis, lung cancer, bronchiectasis, pulmonary tuberculosis, pulmonary embolism and pneumonia. A 67-year old patient was diagnosed to have pepticulcus who was suffering from melana and hematemesis, and then hemoptysis developed while he was being treated in gastroenterology clinic. Because of this, we consultated him. In his case history, diabetes, hypertension, and a coronary bypass operation 3 years ago were available. In the chest radiograph, a homogenous and smooth-edged lesion sized 5x5 cm was observed on the periphery of the right lung. In the computerized tomography, lung fistulization and thrombosed fluid collection that is making pressure on the heart was observed on the right lung. The patient was operated in the cardiovascular surgery, and as a result of the rupture of the saphen graft that was placed during the bypass operation, right lung fistulization and hemoptysis developed. Thus, we found it appropriate to present this case as a rare cause of hemoptysis.
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    Relationship Between Pregnancy-Associated Plasma Protein-A and Lung Cancer
    (Elsevier Science Inc, 2009) Bulut, Ismet; Coskun, Abdurrahman; Ciftci, Abdullah; Cetinkaya, Erdogan; Altiay, Gundeniz; Caglar, Tuncay; Gulcan, Erim
    Background: Pregnancy-associated plasma protein-A (PAPP-A) has insulin-like growth factor (IGF)-dependent IGFBP-4 protease activity and plays an important role in amplifying local IGF-1 activity in wound healing, vascular repair. and bone remodeling. We postulated that PAPP-A may contribute to the availability and activity of IGFs, which affect lung cancer. Therefore, we determined the levels of PAPP-A in patients with lung cancer and their possible clinical significance. Methods: The study population consisted of 83 patients with lung cancer and 33 healthy subjects as a control group. Serum PAPP-A levels were determined using an ultrasensitive enzyme-linked immunosorbent assay. Results: The serum PAPP-A levels were higher in patients with lung cancer [median (interquartile range) 10.7 (7.6-14.2) ng/mL] than in the control group [6.2 (5.2-9.8) ng/mL, P < 0.001]. There was a significant negative correlation between the serum PAPP-A levels and Karnofsky performance status (r = -0.330; P < 0.001) and a positive correlation with patient age (r = 0.358; P < 0.001). Conclusion: PAPP-A is a proatherosclerotic metalloproteinase that is also thought to be an inflammatory marker. We found that the serum PAPP-A levels increased in patients with lung cancer and postulated that PAPP-A levels may be a prognostic factor in such cases.
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    Socioeconomic features and predisposing factors in patients with bronchiectasis
    (Aves Yayincilik, Ibrahim Kara, 2007) Ozdemir, Levent; Tabakoglu, Erhan; Hatipoglu, Osman Nuri; Altiay, Guendeniz; Ozlen, Burcu; Ciftci, Abdullah; Caglar, Tuncay
    Objectives: The aim of this study was to determine socioeconomic features of cases with bronchiectasis and to determine predisposing factors which might play a role in the development of this condition. Patients and Methods: A total of 69 cases with bronchiectasis (43 males, 26 females; mean age 53.7 +/- 15.6 years) were retrospectively evaluated. Patients, totally in whom the was, predisposing factors for bronchiectasis, cigarette and alcohol consumptions, education and and monthly income levels were recorded. Results: Most of the cases multiple predisposing factors for bronchiectasis. Pneumonia (68%), measles (32%), and tuberculosis (18%) were the most common causes. Forty-two percent of the cases were primary school graduates and 20% never attended school. Fifty-five percent of the cases smoked cigarettes and 19% of the cases used alcohol. The mean monthly income was found to be 438.2 +/- 363 YTL. Conclusion: We concluded that bronchiectasis is prominent among individuals with low socioeconomic level.