Yazar "Carman, Kürşat Bora" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim Yok
    Öğe
    Aquaporin 4 Gene Polymorphism in Children With Febrile Seizure
    (2019) Carman, Kürşat Bora; Tuncel, Tunç; Çalık, Mustafa; Karal, Yasemin; Işıkay, Sedat; Kocak, Ozan; Özçelik, Aysima
    Febrile seizure (FS) has a genetic background. The purpose of this study is to search aquaporin-4 (AQP4) gene polymorphisms in children with FS and to explore their effect on the clinical features of FS. This prospective multicenter, case-control included 122 patients with febrile seizure and matched with age, sex 136 healthy control children. A real-time hybridization method was used to analyze and detect the rs1058424 (A/T) and rs3763043 (C/T) single-nucleotide polymorphisms (SNPs). In patient group, the frequencies of rs3763043 (A/T) genotypes AA, AT and TTwere 48.4%, 42.6%, and 9% respectively, compared with 44,9%, 46,3% and 8,8% respectively, in control group. The results showed that the frequencies of rs1058424 (C/T) genotypes CC, CT, and TT 61,5%, 34,4% and 4,1% respectively in children with febrile seizures, compared 64%, 29,4% and 6,6% respectively in controls (p >0.05). The majority of children experienced simple type FS and their first FS. The statistical analysis showed that wild-type genotype was more common in children with simple FS. There was no statistically significant effect of the SNPs on the features of FS, such as family history, number of seizure or duration. The data obtained from molecular analysis show a lack of association between the rs1058424 (A/T) and rs3763043 (C/T) SNPs and FS in children. This is the first research conducted to examine the relationship between AQP4 and FS.
  • Küçük Resim
    Öğe
    The evaluation of vitamin K status in children with febrile seizure
    (2021) Carman, Kürşat Bora; Karal, Yasemin; Mert, Gülen Gül; Ekici, Arzu; Perk, Pelen; Yarar, Çoşkun; Dinleyici, Ener Çağrı
    Background: Febrile seizure is the most common neurological disorder in childhood. The exact pathophysiology of febrile seizures is unknown. Recent studies showed the role of vitamin K in nonhematological and inflammatory disorders. This study aimed to investigate the serum vitamin K levels in children with febrile seizures. Aims: To evaluate vitamin K levels in children with febrile seizures. Study Design: Prospective case-control study. Methods: This multicenter study examined representative populations in 8 different cities in Turkey between April 1, 2018 and April 1, 2019. Blood samples were taken from all children at presentation. Vitamin K1, vitamin K2, tumor necrosis factor-alpha, interleukin 1 beta, and interleukin 6 levels were determined by enzyme-linked immunosorbent assay. Results: A total of 155 children were included in the study—84 children with febrile seizures and 71 children in febrile control group. Serum vitamin K1 and vitamin K2 levels were also higher in children with febrile seizures than in the controls. The results of statistical analysis showed that vitamin K1 and vitamin K2 levels were correlated with tumor necrosis factor-alpha, interleukin 1 beta, and interleukin 6 levels. The median vitamin K1 and vitamin K2 levels of children experiencing their first febrile seizure were higher than those in children with recurrent febrile seizures. Type of febrile seizure has no effect on serum vitamin K1 and vitamin K2 levels. Conclusion: In children with febrile seizures, vitamin K levels are higher than those in the control group. These new findings may contribute to elucidating the etiopathogenesis of febrile seizures.