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    Successful use of fondaparinux in a child with heparin-induced thrombocytopenia
    (Lippincott Williams & Wilkins, 2012) Tokgoz, Huseyin; Caliskan, Umran; Demir, Muzaffer
    Heparin-induced thrombocytopenia (HIT) is a well described side effect of heparin therapy. A 12-year-old boy developed deep-vein thrombosis. Risk factors for initial thrombosis are antiphospholipid syndrome and heterozygous mutation for prothrombin G20210A. Anticoagulant therapy with warfarin for 12 months was effective, but discontinuation of warfarin after 12 months resulted in recurrence of thrombosis. Unfractionated heparin (UFH) was initiated during the acute period, but heparin-induced thrombocytopenia developed. Transition from UFH to fondaparinux resulted in successful anticoagulation for a period of platelet recovery. We report a case of HIT developing with a background of prothrombotic genetic risk factors and antiphospholipid syndrome. This case study highlights several difficulties in pediatric HIT cases. Blood Coagul Fibrinolysis 23: 769-771 (C) 2012 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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    Two Pediatric Cases of Essential Thrombocytopenia Characterized By Extremely Rare Mutations (CALR and MPL W515K)
    (Amer Soc Hematology, 2015) Tokgoz, Huseyin; Caliskan, Umran; Kucukkaya, Reyhan; Demir, Ahmet; Hancer, Veysel Sabri
    [Abstract Not Available]