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Öğe Asymptomatic choroid plexus cysts in the lateral ventricles: an incidental finding on diffusion-weighted MRI(Springer-Verlag, 2002) Cakir, B; Karakas, HM; Unlu, E; Tuncbilek, NWe assessed the role of diffusion-weighted imaging (DWI) in the detection of choroid plexus cysts. We reviewed more than 1000 patients who had undergone MRI in a 1-year period. We reviewed echo-planar DWI with b = 1000 S/mm(2), acquired at 1.0 tesla, for any difference in signal intensity which might indicate choroid plexus cysts. On conventional images, all cystic lesions were isointense with cerebrospinal fluid, and 72 cysts could not be identified. On DWI, 90 rounded high-signal foci were detected in 58 patients; 64 cysts were bilateral. Focal ventricular expansion due to large cysts was observed in nine cases. DWI were found to show choroid plexus cysts undetected within the cerebrospinal fluid on conventional images.Öğe Bilateral exostoses of the internal auditory canal(Edizioni Centauro, 2005) Unlu, E; Albayram, S; Argimak, Y; Cakir, BAlthough exostoses of the external auditory canal are not uncommon, those of the internal canal are extremely rare, and only a few cases have been reported in the literature. Several of these cases have been verified with radiologic methods. Our aim is to present this rare pathology detected with CT findings associated with literature.Öğe The fate of intramuscularly injected fat autografts: An experimental study in rabbits(Springer, 2004) Aygit, AC; Sarikaya, A; Doganay, L; Top, H; Cakir, B; Firat, MFAn experimental study was designed to assess the viability and revascularization of intramuscularly injected fat autografts. For the study, 18 rabbits were divided into two groups. In the first group, fat was injected intramuscularly (12 rabbits). Autologous fat was obtained from the inguinal area and subsequently injected into the thigh muscle. In the second group, physiologic saline was injected intramuscularly to determine the effects of cannulation and pressure on muscle tissue (6 rabbits). Fat autografts were performed on the right side of the animal, and the left side was used as the control. Scintigraphic imaging and histopathologic examination of the limbs were performed after injection of adipose tissue on days 15, 30, 45, 60, 90. and 120. On the technetium-99m (Tc-99m) hexamethylpropylene amine oxime scintigraphy, whereas similar activity distribution was observed between the left and right thigh on days 15, 30, and 45, there was increased uptake at the right thigh on days 60, 90, and 120. This increased uptake indicates that there is viable fat tissue in this region. Histopathologic evaluation showed that microcysts resulting from degeneration of some adipocytes and inflammatory changes on day 15 additionally increased vascularity and fibrosis in some animals on day 30, as well as fibrosis, microcysties, and focal calcification areas in adipose tissue on day 45 and later. It was observed that adipose tissue survived in more than 50% of the graft area in all the animals. These findings show that fat autografts can survive in muscle tissue with less than 50% fibrotic change.Öğe Inflammatory pseudotumor of the spleen with EBV positivity: report of a case(Wiley-Blackwell, 2004) Puyan, FO; Bilgi, S; Unlu, E; Yalcin, O; Altaner, S; Demir, M; Cakir, BInflammatory pseudotumor (IPT) of the spleen is a rare benign tumor with unknown etiology. It causes problems in the diagnosis because of mimicking some hematopoetic malignancies. Here we report the case of a 36-yr-old woman complaining of nausea and insomnia. Laboratory investigations were limited to increase of leukocyte and thrombocyte count. Ultrasonography and magnetic resonance (MR) imaging showed circumscribed solid lobulated mass, measuring about 6.5 cm in diameter, located in the dorsal region of the spleen. Splenectomy was performed with the differential diagnosis including hamartoma and lymphoma of the spleen. Histological examination of the sharply demarcated splenic mass consisted of myofibroblasts and admixture of inflammatory cells. Immunohistochemistry and in situ hybridization were performed. IPT of the spleen was diagnosed. Epstein-Barr virus (EBV) was detected in the tumor by in situ hybridization. This rare entity is presented because of its clinical, radiological and pathological difficulties in the differential diagnosis.Öğe MRI findings of Wernicke encephalopathy revisited due to hunger strike(Elsevier Ireland Ltd, 2006) Unlu, E; Cakir, B; Asil, TBackground and Purpose: The purpose of this study was to determine the characteristic magnetic resonance imaging (MRI) findings among a group of patients who presented with Wernicke encephalopathy (WE) due to the neurological complications of a long-term hunger strike (HS). Methods: MRI studies also including the fluid-attenuated inversion recovery (FLAIR) sequence and diffusion-weighted imaging (DWI) of six male patients with WE aged from 25 to 38 years (mean age 31 years) were evaluated. Results: In all subjects, T2-weighted sequences, FLAIR and DWI revealed a signal hyperintensity within the posteromedial thalami and surrounding the third ventricle. In particular, on coronal images, the hyperintense areas around the third ventricle showed a suggestive double wing configuration. We observed an increased signal on proton-density and T2-weighted images in the mamillary bodies of three patients. Four patients demonstrated additional hyperintensities within the periaqueductal region and/or the tectal plate. At least one lesion area in five of six patients demonstrated contrast enhancement. Conclusion: The consistent imaging findings of our study suggest that MRI is a reliable means of diagnosing WE. Acute WE is sometimes underdiagnosed, yet early diagnosis and treatment of WE is crucial in order to avoid persistent brain damage. MRI, including postcontrast T1-weighted imaging, DWI beneath standardized T2-weighted imaging, and FLAIR sequences may prove to be a valuable adjunct to clinical diagnosis and to provide additional information in acute and/or subacute WE. (c) 2005 Elsevier Ireland Ltd. All rights reserved.Öğe Persistent large choroid plexus cyst -: A case report(Sci Printers & Publ Inc, 2001) Gücer, F; Yüce, MA; Karasalihoglu, S; Cakir, B; Yardim, TBACKGROUND: Prenatally diagnosed choroid plexus cysts regress or resolve spontaneously during pregnancy. A persistent large choroid plexus cyst with a prenatal diagnosis has not been reported previously CASE: A 28-year-old, healthy primigravida was referred to our department at 32 weeks' gestation for a suspected fetal intracranial anomaly. Ultrasonography revealed a lateral ventricle 13 mm in width. The ventricle was dilated only in the atrium region. The choroid plexus was not distinct from the inner wall of the ventricle and did not fill the atrium of the lateral ventricle. The patient was followed with biweekly ultrasonography until delivery, and the left ventricular width increased from 13 to 17 mm. At 38 weeks' gestation the patient delivered a 3,350-g girl. Magnetic resonance imaging showed a 1.7x2.5x3.0-cm cyst in the left lateral ventricle. Follow-up magnetic resonance imaging scans at 6 and 11 months showed unchanged findings. Clinical and neurologic examinations at 11 months of age showed normal development. CONCLUSION: Although small (<1 cm), postnatally persistent choroid plexus cysts are clinically insignificant variants of normal; the prognosis of large, persistent cysts (1 cm) is less clear. Long-term neurologic follow-up is mandatory for these neonates.Öğe Plasma total homocysteine level and its association with carotid intima-media thickness in obesity(Editrice Kurtis S R L, 2005) Uysal, O; Arikan, E; Cakir, BBackground: Elevated plasma concentrations of total homocysteine (tHcy) and obesity are risk factors for cardiovascular disease. The relationship between hyperhomocysteinemia and obesity has not been totally elucidated. Objective: The first aim of the study was to investigate whether anthropometric measurements and insulin resistance contribute to the variation in homocysteine levels in obese adults. Our second aim was to determine if any relationship exists between the carotid intima-media thickness (IMT) and plasma tHcy levels in obese subjects without traditional cardiovascular risk factors. Material and Methods: Fifty-five obese (15 male, 40 female) and 30 (111 male, 19 female) age- and sex-matched apparently healthy volunteers were included. Exclusion criteria were smoking, hypertension, diabetes, vitamin ingestion, hyperlipidemia, renal failure, liver disease, pregnancy, menopause and secondary obesity such as Cushing's syndrome, hypothyroidism. tHcy, folate, vitamin B-12 levels, fasting insulin, glucose, total cholesterol, triglycerides, HDL, LDL particles, uric acid, creatinine and creatinine clearance were measured. Non-invasive ultrasound measurements of carotid IMT were performed. Results: tHcy levels and carotid IMT were comparable between obese and nonobese subjects. Waist/hip ratio (WHR) was related to tHcy and carotid IMT. Hyperhomocysteinemic subjects (tHcy > 19.2 mu mol/l) had greater WH R than normo-homocysteinemic subjects. Both tHcy levels and carotid IMT were higher in male subjects both in obese and non-obese subjects. No association was observed between insulin resistance and tHcy and carotid IMT. Renal function and abdominal obesity were significant predictors of plasma tHcy levels. Conclusions: We concluded that, in obese subjects who are free from atherosclerosis and impaired renal function, plasma tHcy levels do not differ from healthy subjects. Plasma tHcy concentrations are not related to carotid IMT in obese subjects during the non-atherogenic stage. Although no significant difference was observed between insulin-resistant and insulin-sensitive subjects compared to the plasma tHcy levels, the relationship between tHcy levels and some components of the insulin resistance syndrome may support the opinion that tHcy may be considered a component of the insulin resistance syndrome.Öğe Primary angiosarcoma of the spleen: In vivo and in vitro MRI findings(Elsevier Science Inc, 2001) Karakas, HM; Demir, M; Ozyilmaz, F; Cakir, BPrimary splenic angiosarcomas are extremely rare rumors with very poor prognosis. These tumors, highly aggressive and lethal, present with widespread metastatic disease or splenic ruptures. The possibility to lengthen the survival by splenectomy before the development of splenic rapture makes an early radiological diagnosis a necessity. Multimodality imaging findings of a patient with splenic angiosarcoma is presented. In vivo and in vitro magnetic resonance imaging (MRI) features of the spleen are compared to macro- and micropathological findings. (C) 2001 Elsevier Science Inc. All rights reserved.Öğe Relationship between mastoid pneumatization and middle ear barotrauma in divers(Wiley, 2002) Uzun, C; Adali, MK; Koten, M; Yagiz, R; Aydin, S; Cakir, B; Karasalihoglu, ARObjectives/Hypothesis: Previous studies have shown a relationship between eustachian, tube function and size of mastoid pneumatization, as well as eustachian tube function and middle ear (ME) barotrauma. The purpose of this study is to investigate a possible relationship between size of mastoid pneumatization and ME barotrauma in sports scuba (self-contained underwater breathing apparatus) divers. Study Design: Prospective, blinded. Material and Methods: Twenty-four sports scuba divers (48 ears), who were fit to dive in the predive and otolaryngologic examination, were included in the study. Size of mastoid pneumatization was measured by simplified rectangular dimension method on a mastoid x-ray taken at Schuller's view. Divers were counseled to refer to the investigators if any symptoms occurred during and/or after diving. All symptomatic ears were examined within 24 hours of diving by the same investigator, who was blinded to the degree of pneumatization. Results: ME barotrauma occurred in 15 ears (31%) of 11 divers (46%) at one time or another. The median degree of pneumatization in ears with barotrauma (22.9 cm(2)) was significantly smaller than that in unaffected ears (34.1 cm(2); (P <.001). Furthermore, findings showed that with increasing degree of pneumatization, there was a decreasing risk of symptomatic barotrauma (P <.001). No barotrauma occurred in ears with a pneumatization greater than 34.7 cm(2). However, barotrauma occurred in all 3 ears with a pneumatization degree smaller than 13.6 cm(2). Conclusion: Our findings indicate an in-verse relationship between size of pneumatization and risk of symptomatic ME barotrauma in sport scuba divers.Öğe The role of contrast-enhanced MR angiography in the assessment of recently ruptured intracranial aneurysms: a comparative study(Springer, 2005) Unlu, E; Cakir, B; Gocer, B; Tuncbilek, N; Gedikoglu, MWe evaluated contrast-enhanced MR angiography (MRA) for the identification of recently ruptured cerebral aneurysms. We studied 23 aneurysms in 18 patients (age range 34-72 years) with aneurysms of the anterior (n=17) and posterior (n=6) circulation by comparing 3D time-of-flight (TOF), contrast-enhanced MRA and digital subtraction angiography (DSA). In four of 23 aneurysms, 3D-TOF did not show the lesion. Contrast-enhanced MRA successfully depicted all aneurysms except one. T1 contamination artefacts from subarachnoid or intraparenchymal haemorrhages were evident on the 3D-TOF images in six cases. The artefacts were completely eliminated on the contrast-enhanced MRA images by subtraction of the pre-contrast images. The diagnostic information in patients with subarachnoid haemorrhages (SAHs) provided by contrast-enhanced MRA was comparable to that provided by DSA.Öğe Salivary duct carcinoma of the parotid gland metastasizing to the skin - A case report and review of the literature(Lippincott Williams & Wilkins, 2005) Aygit, AC; Top, H; Cakir, B; Yalcin, OSalivary duct carcinomas of parotid gland are rare, as are the skin metastases from them. Four cases are reported with metastases to the skin. We present an additional case, with Subcutaneous metastases of the back and leg. To our knowledge, this is the first case reported in the literature in which the nodule on an extremity was the metastasis of a salivary duct carcinoma of parotid gland.Öğe Tc-99m MDP and Tl-201 scintigraphy in a case of metastatic meningeal hemangiopericytoma(Lippincott Williams & Wilkins, 2001) Kaya, M; Cermik, TF; Hacimahmutoglu, S; Salan, A; Saridogan, K; Cakir, B; Yigitbasi, ON[Abstract Not Available]
