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Öğe Bronchiolitis Obliterans Organizing Pneumonia: Three Cases Leading to Respiratory Failure(Bilimsel Tip Publishing House, 2005) Altiay, Gundeniz; Hatipoglu, Osman Nuri; Tabakoglu, Erhan; Yalcin, Omer; Caglar, TuncayBronchiolitis obliterans organizing pneumonia (BOOP) is an entity of unknown etiology characterized histologically by granulation tissue plugs within the lumens of small airways extending into the alveolar ducts and airways. The typical presenting symptoms and signs are dyspnea, cough, fever, weight loss, and a chest radiograph with single or multiple alveolar opacities. Some cases progress rapidly and have a poor prognosis. We followed-up three idiopathic BOOP cases in one month. Pathological diagnosis was based on transbronchial lung biopsy (TBLB) in all of them. The characteristic features of all cases were progressive respiratory failure. We treated them with high dose prednisolone for three days (first day 80 mg q6h, second day 80 mg q8h, third day 80 mg q12h) and continued with 1 mg/kg/d prednisolone. We observed rapid radiological and clinical improvement in all cases. Interestingly, these three patients were admitted to our clinic with progressive respiratory failure in the same one month period.Öğe The Influence of the Turkish Anti-Tobacco Law on Primary School Children in Edirne(Galenos Publ House, 2011) Tabakoglu, Erhan; Caglar, Tuncay; Hatipoglu, Osman N.; Altiay, Gundeniz; Edis, Ebru Cakir; Sut, NecdetObjective: The Turkish anti-tobacco law was accepted and effectuated in 1996. All forms of cigarette advertising, the sale of tobacco products to persons under the age of 18 and smoking in public institutions were all restricted. In this paper, we aimed to evaluate the influence of the Turkish anti-tobacco law on children for the periods before the law, after three years and after 10 years. Material and Methods: A self-completed questionnaire was distributed among primary school children. This included questions about the children's smoking habits, their opinions of parents' and teachers' smoking habits, tobacco use in public places and the recognition rate of 16 food, drink, cigarette and toothpaste logos and brand names, The first, second and third applications of the questionnaire were performed with students who attended the same classes in the same primary schools, accounting for 772 children in June 1996, 1,157 children in February 1999 and 719 children in June 2006. Results: When these three periods were evaluated, it could be seen that the prevalence of having smoked significantly decreased (13.9%, 4%, 2.2%, p<0.001), as did the rate of purchasing cigarettes within the past week (36.6%, 29.1%, 15.8%, p<0.001). The disagreement with parents' and teachers' smoking habits and tobacco usage in public places increased significantly (p<0.001), while the recognition rates of some cigarette brand names and logos significantly decreased, specifically with regards to Marlboro, Camel and Samsun (p<0.001). Conclusion: The Turkish anti-tobacco law has had a positive effect on primary school children in Edirne, and therefore could be a model for other countries.Öğe Mortality Rates and Related Factors in Respiratory Intensive Care Unit Patients(Aves, 2007) Altiay, Gundeniz; Tabakoglu, Erhan; Ozdemir, Levent; Tokuc, Burcu; Cevirme, Leyla; Hatipoglu, Osman Nuri; Caglar, TuncayThe aim of this study is to identify the mortality rates and the influential factors in the respiratory intensive care unit (ICU). We prospectively evaluated a total of 150 patients consecutively admitted with respiratory failure between May 2003 and May 2005 in Trakya University Hospital, and 135 patients were enrolled in the study. The patients excluded from the study were the ones who died within the first 24 hours of ICU (n: 8), or had malignant diseases (n: 7). Chi-square test and t-test were used to compare hospital survivors with non-survivors, and logistic regression analysis was performed to define independent factors influencing the mortality rates in the hospital. To determine the efficiency of APACHE II, ROC analysis was used. 92 of the patients were male and 43 were female. The mean age was 64.9 +/- 12.9 years. The mortality rate was 32.6% (n: 44). The highest mortality rate was in patients with severe pneumonia/sepsis. (54.2%). The main conditions independently associated with increased mortality rate were arrhythmias (odds ratio [OR], 8.10; 95% confidence interval [CI], 2.67-24.58; p < 0.05), the need for invasive mechanical ventilation (OR, 6.04; 95% CI, 1.88 - 19.34; p < 0.05), the need for cardiotonic medication (OR: 5.36; % 95 CI: 1.67 - 17.22, p<0.05) and ventilator-associated pneumonia (OR: 5-21; 95% CI: 1.54-17.63; p < 0.05).Öğe A new clinical model in pulmonary embolism and its correlation with V/P scan results(Sage Publications Inc, 2006) Hatipoglu, Osman N.; Hanci, Emel; Tabakoglu, Erhan; Altiay, Gundeniz; Cermik, Tevfik Fikret; Caglar, TuncayThe study was prospectively designed to assess the correlation between a new clinical model empirically developed for acute pulmonary embolism (PE) and ventilation/perfusion (V/P) scan results. One hundred sixty consecutive patients with suspected acute PE underwent clinical evaluation before V/P scintigraphy. The clinical probability of PE was categorized according to a structured clinical model empirically developed as low, intermediate, or high, and the results were compared with those of V/P scintigraphy. Forty, 61, and 59 patients were classified as low, intermediate, and high clinical probability, respectively. Seventy-five percent (30/40) of the patients with low clinical probability were also of low scintigraphic probability or had a normal result (r(s): 0.39, p=0.000); 28% (17/61) of the patients with intermediate clinical probability demonstrated intermediate scintigraphic probability (r(s): 0.20, p=0.012); and 68% (40/59) of the patients with high clinical probability were also of high scintigraphic probability (r(s): 0.43, p=0.000). Overall, the correlation of two scoring systems was statistically significant (r(s): 0.39, p=0.000). Unilateral leg swelling (p=0.027), syncope or near syncope (p=0.002), amputation of a hilar artery (p=0.007), and electrocardiographic signs of right ventricular overload (p=0.000) prevailed in patients with high scintigraphic probability. Syncope-near syncope or hemodynamic collapse PLUS electrocardiographic signs of right ventricular overload or hypoxemia combination had the most significant correlation with a high scintigraphic probability (r(s): 0.31; p=0.000). In conclusion, the new clinical model empirically developed was significantly successful to provide comparable results with V/P scan. This consistency was particularly prominent in patients with low or high clinical probability for PE.Öğe Prevalence of asthma and allergic diseases in primary school children in Edirne, Turkey, two surveys 10 years apart(Wiley, 2010) Selcuk, Ziya Toros; Demir, Ahmet Ugur; Tabakoglu, Erhan; Caglar, TuncayTo assess change in prevalence and risk factors of asthma and allergic diseases among primary school children in rural and urban parts of Edirne, Turkey, a series of cross-sectional studies were conducted in 1994 and 2004. A questionnaire was administered to the parents of primary school children aged 7-12, in urban and rural parts of Edirne, Turkey (5412 in 1994 and 5735 in 2004). Response rates in 1994 and 2004 were 84% and 82.5%, respectively. There were significant differences between the age distribution, urban habitation (1994: 70.1%, 2004: 75.8%, p < 0.001), passive smoking (1994: 74.7%, 2004: 60.0%, p < 0.001), and family atopy (1994: 12.7%, 2004: 18.2%, p < 0.001) between the two surveys. Current prevalence of asthma and wheeze increased in the 2004 when compared to 1994 in both rural and urban regions (current asthma for rural and urban regions, 5.2% and 5.8% in 1994; 8.6% and 12.1% in 2004, respectively). Female-to-male ratio of current asthma increased from 0.7 in 1994 to 0.9 in 2004. Comparison of the risk factors in the two surveys suggested urban habitation and factors other than family atopy, passive smoking and no breast feeding as possible contributors for the increasing asthma and wheeze. Prevalence of asthma and allergic diseases increased among school children in Edirne, Turkey from 1994 to 2004. Life style changes and urbanization could be related to this increasing trend.Öğe A Rare Cause of Hemoptysis(Aves, 2009) Ciftci, Abdullah; Ozdemir, Levent; Hatipoglu, Osman Nuri; Caglar, TuncayHemoptysis is a bleeding in the respiratory system together with a cough. Common causes of hemoptysis are bronchitis, lung cancer, bronchiectasis, pulmonary tuberculosis, pulmonary embolism and pneumonia. A 67-year old patient was diagnosed to have pepticulcus who was suffering from melana and hematemesis, and then hemoptysis developed while he was being treated in gastroenterology clinic. Because of this, we consultated him. In his case history, diabetes, hypertension, and a coronary bypass operation 3 years ago were available. In the chest radiograph, a homogenous and smooth-edged lesion sized 5x5 cm was observed on the periphery of the right lung. In the computerized tomography, lung fistulization and thrombosed fluid collection that is making pressure on the heart was observed on the right lung. The patient was operated in the cardiovascular surgery, and as a result of the rupture of the saphen graft that was placed during the bypass operation, right lung fistulization and hemoptysis developed. Thus, we found it appropriate to present this case as a rare cause of hemoptysis.Öğe Relationship Between Pregnancy-Associated Plasma Protein-A and Lung Cancer(Elsevier Science Inc, 2009) Bulut, Ismet; Coskun, Abdurrahman; Ciftci, Abdullah; Cetinkaya, Erdogan; Altiay, Gundeniz; Caglar, Tuncay; Gulcan, ErimBackground: Pregnancy-associated plasma protein-A (PAPP-A) has insulin-like growth factor (IGF)-dependent IGFBP-4 protease activity and plays an important role in amplifying local IGF-1 activity in wound healing, vascular repair. and bone remodeling. We postulated that PAPP-A may contribute to the availability and activity of IGFs, which affect lung cancer. Therefore, we determined the levels of PAPP-A in patients with lung cancer and their possible clinical significance. Methods: The study population consisted of 83 patients with lung cancer and 33 healthy subjects as a control group. Serum PAPP-A levels were determined using an ultrasensitive enzyme-linked immunosorbent assay. Results: The serum PAPP-A levels were higher in patients with lung cancer [median (interquartile range) 10.7 (7.6-14.2) ng/mL] than in the control group [6.2 (5.2-9.8) ng/mL, P < 0.001]. There was a significant negative correlation between the serum PAPP-A levels and Karnofsky performance status (r = -0.330; P < 0.001) and a positive correlation with patient age (r = 0.358; P < 0.001). Conclusion: PAPP-A is a proatherosclerotic metalloproteinase that is also thought to be an inflammatory marker. We found that the serum PAPP-A levels increased in patients with lung cancer and postulated that PAPP-A levels may be a prognostic factor in such cases.Öğe Skin prick test results in patients from Thrace region presenting with pulmonary symptoms(Aves Yayincilik, Ibrahim Kara, 2007) Edis, Ebru Cakir; Tabakoglu, Erhan; Caglar, Tuncay; Hatipoglu, Osman N.; Altiay, GuendenizObjectives: The aim of the study was to determine the profile of allergen sensitization in patients presenting with pulmonary symptoms. Patients and Methods: Skin test results of 196 patients (136 females, 60 males; mean age 34.7 +/- 11.7 years) presenting with pulmonary complaints between October 1999 and April 2005; total IgE results and allergy information forms were analyzed retrospectively. Results: Median value of IgE was (%25-75) 202 U/ml (118-530) in the patients enrolled. The most frequent symptom was shortness of breath (65.3%), and the second was cough (63.8%). These symptoms aggravated while patients were dusting. Sensitivity to at least one allergen was observed in 59.7% of the patients. Sensitivity to a single allergen was present in 18.9% and to multiple allergens in 40.8% of all patients. The most frequent allergy was determined to house dust mite (39.8%) and was followed by allergy to tree pollens (26%). Sensitivity rate to D. Farinea was 33.7% and 32.7% to D. Pteronyssinus. Conclusion: House dust mite were the primary causes of sensitization in patients presenting with allergic symptoms in the Thrace region. The fact that the symptoms aggravated in 46.9% of the patients while they were dusting at home, seemed to support this finding.Öğe Socioeconomic features and predisposing factors in patients with bronchiectasis(Aves Yayincilik, Ibrahim Kara, 2007) Ozdemir, Levent; Tabakoglu, Erhan; Hatipoglu, Osman Nuri; Altiay, Guendeniz; Ozlen, Burcu; Ciftci, Abdullah; Caglar, TuncayObjectives: The aim of this study was to determine socioeconomic features of cases with bronchiectasis and to determine predisposing factors which might play a role in the development of this condition. Patients and Methods: A total of 69 cases with bronchiectasis (43 males, 26 females; mean age 53.7 +/- 15.6 years) were retrospectively evaluated. Patients, totally in whom the was, predisposing factors for bronchiectasis, cigarette and alcohol consumptions, education and and monthly income levels were recorded. Results: Most of the cases multiple predisposing factors for bronchiectasis. Pneumonia (68%), measles (32%), and tuberculosis (18%) were the most common causes. Forty-two percent of the cases were primary school graduates and 20% never attended school. Fifty-five percent of the cases smoked cigarettes and 19% of the cases used alcohol. The mean monthly income was found to be 438.2 +/- 363 YTL. Conclusion: We concluded that bronchiectasis is prominent among individuals with low socioeconomic level.Öğe Treatment of a primary pulmonary alveolar proteinosis case with severe hypoxaemia by using segmental lavage technique(Acad Medicine Singapore, 2007) Edis, Ebru Cakir; Tabakoglu, Erhan; Caglar, Tuncay; Hatipoglu, Osman Nuri; Cevirme, Leyla; Alagol, Aysin[Abstract Not Available]
