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Öğe Intranasal miRNAs-17/20 Administration Alleviates Early Brain Injury After Subarachnoid Hemorrhage in Rats(Springer, 2023) Malcok, U. A.; Doganlar, O.; Tufekcioglu, N. K.; Ovali, M. A.; Aykora, D.; Doganlar, Z. B.; Buyuk, B.Early brain injury (EBI) in the first 24-72 h is the leading cause of mortality and disability related to subarachnoid hemorrhage (SAH). Both melatonin and microRNAs (miRs) are involved in the regulation of a number of neuronal molecular signaling procedures in the central nervous system, ranging from hypoxia, inflammation to neuronal apoptosis. The present study was performed to explore the effect of miRs-17/20 and combined treatment with melatonin on early brain injury after SAH and underlying molecular mechanisms in rats. In this study 54 Wistar albino rats were divided into six experimental groups: Sham, SAH, SAH + Melatonin, SAH+miRs-17/20 control, SAH+MEL+miRs-17/20, and SAH+MEL+miRs-17/20. The Garcia's Neurological Scoring Scale and motor coordination tests were used for clinical observation. H&E staining was performed to evaluate pathological score. The gene expression levels were determined by qRT-PCR and key proteins were quantitated by Western blot assay. miRs-17/20 with or without melatonin treatment suppressed the expression and activity of both the HIF1/VEGF/MMPs and the IL6R/JAK2/STAT3 axis. miRs-17/20 with or without melatonin treatment also mitigated the clinical impairment, pyknosis, and edema in the hippocampus and cortex and neurodegeneration induced by SAH. Our results show that miRs-17/20 alleviated EBI by reducing hypoxic conditions, hypoxia-induced molecular signaling, and neuronal apoptosis.Öğe Investigation of Natural Radioactivity of Surface Soil Samples in the Vicinity of Edirne-Turkey(Polish Acad Sciences Inst Physics, 2016) Zaim, N.; Tugrul, A. B.; Atlas, H.; Buyuk, B.; Demir, E.; Baydogan, N.; Altinsoy, N.The study was carried out to determine radioactivity concentrations in surface soil samples of the city of Edirne in connection with the potential radiological hazards due to Chernobyl event. The natural radionuclide ((226)Ra, (232)Th and (40)K) contents were determined for nine different locations in nine different towns of the Edirne city. Radiation levels were measured. Natural beta-ray activity was also determined for the same locations. The average estimated activity values were determined and compared with reported values for other cities in Turkey and also for many countries of the world. The studied areas do not pose radiological risks to the inhabitants due to harmful effects of the ionizing radiation from the natural radioactivity of the soil.