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    Comparison of Medicaments Used in Regenerative Endodontics in Terms of Dentin Microhardness and Adhesion of Mineral Trioxide Aggregate
    (Univ Indonesia, Fac Dentistry, 2020) Saricam, Esma; Bulak, Neslihan; Ozyurt, Esra; Ozcan, Suat
    Eliminating microorganisms in the root canal system is important for the success of regenerative endodontics. Objective: This study evaluated the effects of different antibiotic pastes used for regenerative endodontic procedures on dentin microhardness and the push-out bond strength of mineral trioxide aggregate (MTA) to root canal dentin. Methods: Sixty-four maxillary central incisors were instrumented and randomly divided into the following four groups (n = 16) for medicament treatment: triple antibiotic paste, amoxicillin+clavulanic acid, cefaclor, and control (no dressing). After 21 days, two root segments were obtained by sectioning the roots horizontally for push-out and microhardness evaluations. MTA was placed into the root canal of the sectioned segment for the push-out test. In the microhardness evaluation, three indentations were made at 500 and 1,000 mu m from the canal lumen. The arithmetic mean was then calculated for each distance. ANOVA with post hoc Scheffe test and t test were used for the statistical analyses. The significance level was set at p < 0.05. Results: No significant difference was found between the groups in terms of push-out bond strength (p > 0.05). Cefaclor and amoxicillin+clavulanic acid reduced the microhardness values of the dentin at 500 mu m (p < 0.05) while cefaclor had the lowest value at 1,000 mu m (p < 0.05). Conclusion: Cefaclor reduced the microhardness value more than the other medicaments did at a depth of 1,000 mu m. The pastes provided similar adhesion of MTA.