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    Serum neutrophil-lymphocyte ratios, C-reactive protein and sedimentation levels in Parkinson's disease
    (Cukurova Univ, Fac Medicine, 2018) Solmaz, Volkan; Genc, Elmas Pekdas; Aksoy, Durdane; Cevik, Betul; Kurt, Semiha Gulsum; Benli, Ismail
    Purpose: We aimed to investigate the systemic inflammation status by analyzing the Neutrophil/Lymphocyte (N/L) ratio, Erythrocyte Sedimentation Rate (ESR), and C - reactive protein (CRP) in patients with Parkinson's disease (PD). Materials and Methods: 101 PD patients, and 60 healthy subjects of similar age and gender were include in this study. The demographic data and duration of the disease, the drugs, duration of usage of Parkinson drugs, Hoehn-Yahr stage were noted. After full neurological examination blood samples are collected and neutrophil, lymphocyte counts, high sensitive CRP, ESR levels are detected. Results: The N/L ratio and the CRP levels were statistically higher in Parkinson's group. There was a statistically significant but weak positive correlation between the CRP levels and the N/L ratio with the disease duration. Similarly, there was a statistically significant but weak positive correlation between the CRP levels and the N/L ratios with Hoehn-Yahr stages. When the N/L rates of the Parkinson's patients were correlated with the CRP and the ESR levels separately, it was observed that there was a weak but statistically significant correlation between the CRP and the N/L ratio Conclusion: N/L ratio, and CRP levels, which are very important indicators of peripheral inflammation, was higher in PD. Our findings suggest that these biochemical markers may have a predictive value for the diagnosis of PD.