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    The Effect of N-acetylcysteine on Brain Tissue of Rats Fed with High-Cholesterol Diet
    (Walter De Gruyter Gmbh, 2008) Eskiocak, Sevgi; Altaner, Semsi; Bayir, Serpil; Cakir, Erol
    Objectives: The effect of N-acetylcysteine in rats fed a high-cholesterol diet on oxidative stress in the plasma and brain tissue of rats was investigated. Methods: The animals were maintained on a basal diet (control, n=10) or a high-cholesterol diet (1 % w/w) for eight weeks. The rats fed high-cholesterol diet were separated to three group; high-cholesterol diet (n=10), low N-acetylcysteine (n=10) and high N-acetylcysteine groups (n=9). Low and high N-acetylcysteine groups received N-acetylcysteine at a dose of 50 and 100 mg/kg/day respectively via intraperitoneally for eight weeks. Malondialdehyde, glutathione, nitric oxide, cholesterol and triglyceride levels were analyzed in the samples. The results were analyzed by Kruskal-Wallis variance analysis and then a Mann-Whitney U test. Results: When N-acetylcysteine was administered at a low dose, lipid peroxidation products in the brain significantly decreased compared with the high-cholesterol group, while glutathione content enhanced. On the other hand, when N-acetylcysteine was administered at a high dose, lipid peroxidation products in the brain and plasma significantly increased compared with the control group. Conclusions: These results suggest that N-acetylcysteine has a dual effect. If the N-acetylcysteine dose was carefully selected, N-acetylcysteine may have a neuroprotective effect against oxidative stress and hypercholesterolemia.