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Öğe BLK Pathway-Associated rs13277113 GA Genotype Is More Frequent in Systemic Lupus Erythematosus Patients and Associated with Low Gene Expression and Increased Flares(Wiley, 2015) Pamuk, Omer Nuri; Gurkan, Hakan; Balci, Mehmet Ali; Tozkir, Hilmi; Duymaz, Julide; Sari, Gulce; Yazar, Metin[Abstract Not Available]Öğe Comparison of Adherence to Disease Modifying Antirheumatic Drugs in Psoriatic Arthritis and Other Rheumatic Disease(Wiley, 2016) Balci, Mehmet Ali; Oksuz, Mustafa Ferhat; Donmez, Salim; Ozen, Tugce; Dalkilic, Ediz; Tufan, Ayse Nur; Pehlivan, Yavuz[Abstract Not Available]Öğe Development of systemic sclerosis in a patient with common variable immunodeficiency(Academic Press Inc Elsevier Science, 2015) Balci, Mehmet Ali; Pamuk, Gulsum Emel; Donmez, Salim; Pamuk, Omer Nuri[Abstract Not Available]Öğe The epidemiology of dermatomyositis in northwestern Thrace region in Turkey: epidemiology of dermatomyositis in Turkey(Springer Heidelberg, 2017) Balci, Mehmet Ali; Donmez, Salim; Saritas, Fatih; Bas, Volkan; Pamuk, Omer NuriDermatomyositis (DM) is a rare disease that may affect the skeletal muscles and the skin. Literature data on its incidence and prevalence are limited. There are no data on its incidence or prevalence in Turkey. Patients diagnosed with DM at the Trakya University Medical Faculty, Department of Rheumatology from November 2004 to November 2014 were reviewed retrospectively. Patients' clinical and demographic features, laboratory data, treatment modalities, follow-up durations, disease courses, outcomes, and complications were evaluated. Our study included 23 patients with DM; 14 were females and 9 were males (female/male: 1.55). Over the course of the study, the annual incidence of DM was 3.7 per million (95% CI 0-18.8) person years, and the overall prevalence was 32.2 per million (95% CI 18.1-46.3). Incidence in women was higher (4.6/1,000,000 person years) compared to men (2.9/1,000,000 person years). The frequencies of most common findings were as follows: heliotrope rash (82.6%), Gottron papules (87%), proximal myopathy (78.3%), and facial erythema (60.9%). In our hospital-based study, the frequency of DM was lower than those reported in North America; however, they were similar to European countries.Öğe General Features of SLE Patients Presenting with Autoimmune Hemolytic Anemia(Wiley, 2016) Elezi, Regaip; Pamuk, Gulsum Emel; Maden, Muhammet; Balci, Mehmet Ali; Pamuk, Omer Nuri[Abstract Not Available]Öğe The Incidence and Prevalence of Systemic Sclerosis in Northwestern Part of Turkey(Wiley, 2016) Pamuk, Omer Nuri; Balci, Mehmet Ali; Donmez, Salim; Pamuk, Gulsum Emel[Abstract Not Available]Öğe Investigation of Genes Associated With Atherosclerosis in Patients With Systemic Lupus Erythematosus(Turkish League Against Rheumatism, 2021) Balci, Mehmet Ali; Atli, Engin; Gurkan, HakanObjectives: In this study, we aimed to identify patients with systemic lupus erythematosus (SLE) who are genetically at risk for developing atherosclerosis. Patients and methods: Between November 2014 and May 2016, a total of 38 patients with SLE (36 females, 2 males; mean age: 37.6 years; range, 18 to 71 years) and 32 healthy females (mean age: 31.5 years; range, 19 to 54 years) were included in the study. Carotid intima-media thickness (CIMT) was measured using high-resolution B-mode ultrasonography. SurePrint G3 Human Gene Expression 8x60K Microarray kit was used in our study. Genes showing differences in expression between the groups were identified by using GeneSpring GX 10.0 program. Pathway analyses of gene expressions were performed using Ingenuity Pathways Analysis (IPA). Gene ontology analyses were performed using the Protein Analysis Through Evolutionary Relationships (PANTHER). Results: Clinical findings of SLE patients were mainly photosensitivity (71.1%), arthritis (63.2%), lupus nephritis (55.3%), thrombocytopenia (26.3%), and autoimmune hemolytic anemia (21.1%). A total of 155 genes showing expression level difference were detected between SLE patients and healthy controls. In molecular network analysis, 28.2% of all genes were found to be directly or indirectly associated with atherosclerosis and cardiovascular disease. Conclusion: In SLE patients, many genes are expressed differently from healthy individuals. Expression of these genes is important in the pathogenesis of SLE. Genes identified differently in gene expression analysis can help us to identify SLE patients at risk for atherosclerosis in the Turkish population.Öğe Performance of the New ACR Criteria in Systemic Sclerosis: A Multi-center Study(Wiley, 2014) Cakir, Necati; Pamuk, Omer Nuri; Balci, Mehmet Ali[Abstract Not Available]Öğe Performance of the new American College of Rheumatology classification criteria in Turkish systemic sclerosis patients: a multicenter study(Springer London Ltd, 2016) Pamuk, Omer Nuri; Balci, Mehmet Ali; Onat, Ahmet Mesut; Zengin, Orhan; Cakir, Necati; Kisacik, BunyaminIn our study, we compared the sensitivity and specificity of the new ACR/EULAR 2013 criteria to the ACR 1980 criteria in our systemic sclerosis (SSc) population. Three rheumatology centers from Turkey participated into this study. The medical records of SSc patients diagnosed between 2008 and 2014 were retrospectively reviewed, and their features at disease onset were recorded. Patients admitted to each center within the same time period for conditions other than SSc, in whom ANA was positive and was deemed necessary within the diagnostic workup, were included as controls. One hundred and ninety-seven SSc patients (174 females, 23 males) and 103 controls (96 females, 7 males) were included. Limited cutaneous SSc was present in 68 % of patients, and 30.5 % had diffuse SSc. The sensitivity of ACR/EULAR 2013 and ACR 1980 criteria were, respectively, 94.4 and 85.3 % (p = 0.003). The specificity of ACR/EULAR 2013 and ACR 1980 criteria were, respectively, 98.1 and 100 %. According to the new criteria, 13 patients were misclassified; however, according to the ACR 1980 criteria, 29 patients were misclassified (p = 0.005). The sensitivity of ACR/EULAR 2013 criteria was significantly better than that of the ACR 1980 criteria in limited cutaneous SSc group (94.8 vs. 82.8 %). In patients whose disease duration was < 3 years, the new criteria had better sensitivity than the previous criteria (92.7 vs. 78.1 %, p = 0.006). The new ACR/EULAR 2013 criteria for SSc had better sensitivity in Turkish SSc patients, and less patients were misclassified.Öğe The Survival and Prognostic Factors of Patients with Systemic Sclerosis Turkish Experience(Wiley, 2016) Zengin, Orhan; Balci, Mehmet Ali; Pamuk, Omer Nuri; Kisacik, Bunyamin; Donmez, Salim; Onder, Mustafa Erkut; Aksoy, Savas[Abstract Not Available]
