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Öğe Anti-hcv pozitif hemodiyaliz hastalarında eritrosit ve serum ferritin düzeyleri ile karaciğer enzim düzeyleri arasındaki ilişkinin değerlendirilmesi(2008) Mağın, Hasan; Seymen, Pınar; Aydemir, Birsen; Gülyaşar, Tevfik; Seymen, H. Oktay; Demirtunç, RefikAmaç: Hepatit C enfeksiyonu olan hastalarda, kronik enflamasyona bağlı olarak hepatosellüler depolardan ferritin salınmakta ve bu hepatosellüler hasarın bağımsız bir göstergesi olarak kabul edilmektedir. Serum eritrosit ferritin seviyelerinin, serum ferritin düzeyleri gibi, karaciğer hasarını göstermede aminotransferazlar ile birlikte kullanılıp kullanılamayacağı bilinmemektedir. Çalışmamızda amacımız, anti-HCV pozitif hemodiyaliz hastalarında, karaciğer hasarının göstergesi olan aminotransferaz enzim düzeyleri ile eritrosit ve serum ferritin düzeyleri arasındaki ilişkiyi ortaya koymaktır. Gereç ve yöntem: Beş farklı diyaliz merkezinde diyalize giren, aktif enfeksiyonu, malignitesi ve polisitemisi bulunmayan, kan transfüzyonu yapılmamış, anti- HCV' si pozitif 40 hastada eritrosit ferritin, serum ferritin, CRP, HBsAg, anti-HİV, anti-HCV, ALT (alaninaminotransferaz ) ve AST (aspartat aminotransferaz) düzeylerine bakıldı. SPSS (ver. 12) istatistik programı kullanılarak sonuçlar değerlendirildi. Bulgular: Hastaların 17' si erkek 23'ü kadın olup yaş ortalamaları 54±16 yıl, ALT 25 ±19 IU/L, 20±12 IU/L, eritrosit ferritin değerleri 1,8 ± 1,72 ng/gHb, serum ferritin değerleri 992±424 ng/ml olarak bulundu. Yapılan değerlendirmede, serum aminotransferaz değerleri ile serum ferritin değerleri arasında istatistiksel olarak anlamlı pozitif korelasyon saptandı (p< 0,05), ancak eritrosit ferritin ile aminotransferazlar düzeyleri arasında istatistiksel olarak anlamlı pozitif korelasyon saptanmadı (p> 0,05). Sonuç: Anti-HCV pozitif hastalarda hepatosellüler depolardan salınan serum ferritin seviyeleri aminotransferaz enzimleri ile birlikte karaciğer hasarının göstergelerinden biridir. Yaptığımız çalışmada, aminotransferaz seviyeleri ile serum ferritin düzeyleri arasında anlamlı korelasyon saptandı, ancak eritrosit ferritin düzeyleri ile aminotransferaz seviyeleri arasında anlamlı bir korelasyon saptanamamıştır. Bulgular HCV pozitif hemodiyaliz hastalarında, eritrosit ferritin seviyelerinin karaciğer hasarını göstermede serum ferritin gibi iyi bir belirteç olarak kullanılamayacağını düşündürmektedir.Öğe Comparison of Before and After Varicocelectomy Levels of Trace Elements, Nitric Oxide, Asymmetric Dimethylarginine and Malondialdehyde in the Seminal Plasma and Peripheral and Spermatic Veins(Humana Press Inc, 2015) Kiziler, Ali Riza; Aydemir, Birsen; Guzel, Savas; Yazici, Cenk Murat; Gulyasar, Tevfik; Malkoc, Ercan; Acar, AyseIncreased oxidative damage has been suggested to play an important role in the spermatogenesis and sperm function changes in patients with varicocele. However, changes in levels of nitric oxide (NO), asymmetric dimethylarginine (ADMA), malondialdehyde (MDA), iron (Fe), zinc (Zn) and copper (Cu) in blood and seminal plasma, and semen quality, are unknown. The aim of this study was to investigate the NO, ADMA, Fe, Cu, Zn and MDA levels from seminal plasma and peripheral and spermatic vein blood samples of patients with varicocele before and after varicocelectomy. In this before and after comparative study, 29 consecutive patients attending a training hospital in Tekirdag, Turkey, were recruited. MDA and NO levels were determined by spectrophotometric methods. The levels of ADMA were determined by enzyme-linked immunosorbent assay method. Trace element level was determined by atomic absorption spectrophotometric method. The levels of MDA in the seminal plasma and peripheral and spermatic vein samples were observed to decrease significantly in the comparison of before and after phases of the study group (p= 0.022, p= 0.001 and p= 0.034, respectively). Also, the levels of NO in the seminal plasma and spermatic vein samples decreased significantly in the comparison of before and after phases of the study group (p= 0.025 and p= 0.001, respectively), while the levels of ADMA in seminal plasma and spermatic vein samples increased significantly in the comparison of before and after phases of the study group (p= 0.003 and p= 0.001, respectively). There were no significant differences in the levels of trace elements and sperm count (p> 0.05). Oxidative stress is significantly higher in the spermatic vein and seminal plasma samples of patients with varicocele before varicocelectomy. In conclusion, these events may be evaluated accordingly for the potentially beneficial treatment methods.Öğe THE EVALUATION OF RELATIONSHIP BETWEEN ERYTHROCYTE AND SERUM FERRITIN LEVELS WITH AMINOTRANSFERASE ENZYME LEVELS IN ANTI-HCV POSITIVE HEMODIALYSIS PATIENTS(Istanbul Univ, Faculty Medicine, Publishing Office, 2008) Magin, Hasan; Seymen, Pinar; Aydemir, Birsen; Gulyasar, Tevfik; Seymen, H. Oktay; Demirtunc, RefikObjective: Serum ferritine level which is released from hepatocellular stores due to chronic inflammation of HCV infection, is accepted as an independent indicator of hepatocellular damage. It is not known whether intra- erythrocyte ferritin could be used as an indicator of hepatocellular damage as with serum ferritin, AST and ALT. In our study, we evaluated the relationship between aminotransferase level with eriythrocyte ferritin level and serum ferritin level in anti- HCV positive hemodialysis patients. Materials and methods: 40 HCV patients, taking hemodalysis therapy at five different hemodialysis center, were included in the study. They had no active inflamation, malignity and policytemia and had not been given blood transfusion. Erythrocyte and serum ferritin, ALT, AST, CRP, HBs- Ag, anti- HCV, anti- HIV levels were detected. The results were evaluated by using SPSS (ver. 12) statistics program. Results : 17 male and 23 female patients were taken to study and their average age was 54 +/- 16 year. Their alanineaminotransferase values were 25 +/- 29 IU/L, their aspartat aminotransferase values 20 +/- 12 IU/L, erythrocyte ferritin values 1.8 +/- 1.72 ng/gHb and their serum ferritin values were 992 +/- 424ng/ml. When the data evaluated, it was found that, there is a statistically significant positive correlation between the serum aminotransferase levels and the serum ferritin levels (p<0.05), whereas there was no statistically significant pozitif correlation between aminotransferase levels and erythrocyte ferritin levels (p>0.05). Conclusion: In HCV positive patients, AST, ALT and serum ferritin released from hepatoselluler stores shows liver damage. We found a significant positive correlation between aminotransferase levels and serum ferritin levels, but not with erythrocyte ferritin levels. This finding lead us to a conclusion that, erythrocyte ferritin levels are not a good marker for showing hepatocellular damage as like serum ferritin levels in HCV positive hemodialysis patients.Öğe High levels of cadmium and lead in seminal fluid and blood of smoking men are associated with high oxidative stress and damage in infertile subjects(Humana Press Inc, 2007) Kiziler, Ali Riza; Aydemir, Birsen; Onaran, Ilhan; Alici, Bulent; Ozkara, Hamdi; Gulyasar, Tevfik; Akyolcu, Mehmet CanWe measured the levels of malondialdehyde (MDA), protein carbonyls, glutathione S-transferase (GST) and reducte glutathione (GSH) in seminal plasma and spermatozoa from 95 subjects including 50 infertile patients to evaluate the association between oxidative stress and damage and the components of the anti-oxidant defenses in seminal plasma and spermatozoa of infertile subjects and concentrations of cadmium (Cd) and lead (Pb) in the blood and seminal plasma because of tobacco smoke exposure. The reactive oxygen species (ROS) in spermatozoa were also evaluated by luminol (5-amino-2,3-dihydro-1,4-phthalazinedione)-enhanced chemiluminescence assay. The sperm count, motility, and morphology in the smokers infertile group were found to be lower than those in the fertile male group and nonsmokers infertile group (p < 0.001). Concentrations of Cd, Pb, MDA, protein carbonyls, and ROS levels in the smokers infertile group were significantly higher than those in the fertile male and nonsmokers infertile male groups (p < 0.001). However, GSH levels and GST activities were decreased in the smokers infertile male group than those in the fertile male and nonsmokers infertile male groups (p < 0.001). The results indicate that smoking could affect semen quality and oxidative lipid and protein damage in human spermatozoa. From Pearson correlation analysis, positive correlations were demonstrated between the seminal plasma Cd and seminal plasma protein carbonyls and between seminal plasma Pb and spermatozoa ROS levels in smokers of the subfertile group, while there was a significant positive correlation between blood Cd and ROS levels in smokers of the fertile group. There was also a significant negative correlation of the Cd level of the blood and GSH levels of the sperm and seminal plasma. These findings suggest that cigarette smoking enhances the levels of Cd and Pb in seminal plasma and blood and the extent of oxidative damage associated with a decrease in components of the anti-oxidant defenses in the sperm of infertile males.Öğe Relationships among iron, protein oxidation and lipid peroxidation levels in rats with alcohol-induced acute pancreatitis(Humana Press Inc, 2008) Kiziler, Ali Riza; Aydemir, Birsen; Gulyasar, Tevfik; Unal, Ethem; Gunes, PembegulIt has been previously shown that alcohol induces the damage of pancreatic parenchyma tissue, but the mechanism of this damage is still poorly understood. Assuming that oxygen radical damage may be the involved, we measured markers of oxidative damage in pancreatic tissue, blood serum, plasma, and whole blood of rats with early-stage alcohol-induced acute pancreatitis. Thirty-eight male Wistar rats were divided into three groups: the control group (group 1), the acute pancreatitis group 1 day (group 2), and 3 days (group 3) after the injection of ethyl alcohol into the common biliary duct, respectively. The levels of Fe in tissue and serum, whole blood viscosity, plasma viscosity, fibrinogen and homocysteine (Hcy) levels, erythrocyte and plasma malondialdehyde (MDA), and tissue and plasma protein carbonyl levels were found to be significantly higher in groups 2 and 3 than in group 1. However, the levels of reduced glutathione (GSH) in tissue and erythrocytes were significantly lower in groups 2 and 3 than in group 1. These results suggest that elevated Fe levels in serum and pancreatic tissue in rats with early-stage alcohol-induced acute pancreatitis is associated with various hemorheological changes and with oxidative damage of the pancreas.Öğe Roles of selenoprotein K and selenium status in the etiopathogenesis of preeclampsia: Their relationships with maternal lipid peroxidation, oxidative DNA damage, and glutathione peroxidase(Dustri-Verlag Dr Karl Feistle, 2018) Cinemre, Fatma Behice Serinkan; Aydemir, Birsen; Gulyasar, Tevfik; Cinemre, Hakan; Tuten, Abdullah; Yolmaz, Nevin; Yoldoz, MustafaObjective: Preeclampsia (PE) is a complex disease and the underlying mechanisms are not known yet. It is well known that selenium and oxidative stress play a role in the pathogenesis of various diseases as well as PE. The aim of the study was to investigate the changes in selenium status, as an essential trace element, and selenoprotein K (SelK), a newly described selenoprotein which has been suggested to have an antioxidant function in some tissues in patients with preeclampsia. We also aimed at investigating their relationships with maternal lipid peroxidation, oxidative DNA damage, and glutathione peroxidase (GPx) activities. Materials and methods: 38 healthy pregnant and 48 pregnant women with PE were included in the study. Serum selenium levels were measured by graphite-furnace atomic absorption spectrophotometry. Plasma TBARS levels were analyzed by spectrophotometric method; GPx activities, 8OHdG, and SelK levels were determined by ELISA. Results: Plasma TBARS and 8OHdG levels were found to be increased in the PE group compared to the healthy pregnant group. Plasma SelK levels and GPx activities were found to be lower in the PE group than in the healthy control group. However, there was no significant difference in serum selenium levels between two groups. Furthermore, a significant correlation was determined between plasma SelK levels and GPx activities in PE patients group (r = 0.743; p < 0.01). Likewise, a significant positive correlation was found between plasma 8OHdG and TBARS levels (r = 0.457; p < 0.01), serum selenium levels and plasma GPx activities (r = 0.663; p < 0.01), serum selenium and plasma SelK levels (r = 0.851; p < 0.01) in PE. Conclusion: Our findings indicated that a selenoprotein SelK and a selenoenzyme GPx play a role in the etiopathogenesis of PE. Decreases in these antioxidant systems were associated with increase in lipid and DNA oxidation in PE patients. Underlying mechanisms of SelK and its interactions with selenium status and GPx in PE should be clarified in details with further studies.Öğe THYROID DYSFUNCTIONS DUE TO LITHIUM TREATMENT IN BIPOLAR DISORDER: CHANGES IN OXIDATIVE STRESS, TRACE ELEMENTS, AND HEMORHEOLOGICAL PARAMETERS(Polish Society Magnesium Research, 2020) Bahtiyar, Nurten; Cinemre, Fatma Behice Serinkan; Cinemre, Hakan; Kiziler, Ali Riza; Atagun, Murat Ilhan; Gulyasar, Tevfik; Aydemir, BirsenLithium is one of the most widely used medications for the treatment of bipolar disorder (BD). It also has some side effects on thyroid functions. We aimed to investigate the role of oxidative stress, trace elements, and hemorheological parameters on the pathophysiology of thyroid dysfunctions developed by lithium treatment in patients with BD. Patients with BD were divided into three groups: patients that non-lithium-treated, lithium-treated patients for 4-6 weeks, and lithium-treated patients for 40-68 weeks. Blood samples for analysis were taken before and after the treatment period. After analysis, patients were divided into six groups: non-treatment BD group (Group 1); short-term lithium-treatment group that did not develop thyroid dysfunctions (Group 2); short-term lithium-treatment group that developed hyperthyroidism (Group 3); long-term lithium treatment group that developed hypothyroidism (Group 4), long-term lithium-treatment group that developed hyperthyroidism (Group 5), and long-term lithium-treatment group that did not develop thyroid dysfunctions (Group 6). Plasma and whole blood viscosity levels were significantly increased in Groups 4 and 6 compared to Groups 1, 2, and 3. Hemoglobin levels were lower in Group 4 than in Groups 1, 2, and 5. Fibrinogen values were higher in Groups 4 and 5 than Group 1. Plasma and erythrocyte malondialdehyde levels were higher in Group 4 than In Groups 1, 2, 3, and 5. Also, they were increased in Group 6 in comparison with Groups 2 and 3. Erythrocyte glutathione levels were lower in Groups 4 and 6 than Groups 1, 2, 3 and 5. Plasma protein carbonyls levels were higher in Group 4 than in Group 1, or in Group 5 than in Groups 1, 2, and 3, as well as in Group 6 than Groups 1, and 2. Serum zinc levels were higher in Groups 2, 3 and 6 than in Group1. Serum copper levels increased in Groups 2, 4 and 6 in comparison with Group1. The results of this study indicate that oxidative stress increased with treatment time in lithium-induced thyroid dysfunctions. Also, whole blood viscosity, plasma viscosity, fibrinogen, zinc, and copper levels were affected by lithium treatment and treatment duration induced thyroid dysfunctions.
