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    RAR? gene methylation is a candidate for primary glioblastoma treatment planning.
    (Makerere Univ, Fac Med, 2016) Atli, Emine Ikbal; Kalkan, Rasime; Ozdemir, Muhsin; Aydin, Hasan Emre; Arslantas, Ali; Artan, Sevilhan
    Background: We screened RAR beta methylation in primary glioblastoma multiforme (GBM) and the results were evaluated based on the clinical data and treatment type. Objective: The objective of this study was to find new areas for the usage of MS-HRM applications in the determination of methylation levels in primary GBM samples and it shows the association of RAR beta methylation with the clinical outcome. Methods: In our study, tumor samples were collected during surgical resection by the Department of Neurosurgery. The clinical and radiologic data was carefully reviewed, compared, and evaluated with the histological results. The methylation status of RAR beta was determined by using MS-HRM. Results: RAR beta gene methylation was detected in 24 out of 40 cases (60%), with different quantitative methylation levels. The mean survival time was 19 months form ethylated cases and 15 months for the non-methylated cases. The survival time of the patients who received treatment was 25 months and the survival time of the patients who received radiotherapy alone or where no treatment protocol applied was 15-20 months. Therefore, a significant difference in survival rates has been observed (P< 0.05). This study indicates a potential prognostic value for GBM treatment planning. Conclusion: Our study is the first study to investigate RAR beta methylation in primary GBMs. We conclude that the RAR beta gene could be a new prognostic and predictive candidate marker to designate the treatment protocol for primary GBMs.
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    Therapeutic efficacy of tadalafil and eriythropoietin in experimental spinal cord injury
    (Turkish Assoc Trauma Emergency Surgery, 2016) Kokoglu, Cagri; Delen, Emre; Arslantas, Ali; Arslantas, Didem; Kokoglu, Burcu; Ozbek, Zuhtu; Uslu, Sema
    BACKGROUND: This experimental study was an investigation of the efficacy of erythropoietin and tadalafil in rats with induced spinal cord injury (SCI). METHODS: Thirty-five Sprague Dawley rats were distributed into 5 groups. First group was used for normal biochemical values. Spinal cord injury was induced in 4 remaining groups with clip compression technique after laminectomy process to T10 vertebra. Second group was designated solvent group and received 1 cc physiological serum after injury. Third group was medicated with intraperitoneal 2000 u/kg single dose erythropoietin after injury. Orogastric 2 mg/kg single dose tadalafil was administered to fourth group after injury. Fifth group did not receive any treatment and was used for biochemical values with injury. All subjects were sacrificed 48 hours after application. Malondialdehyde (MDA) and total antioxidant capacity (TAOC) values were evaluated using blood and tissue samples. RESULTS: Lowest serum and tissue MDA values were found in group with erythropoietin intake. While highest serum TAOC values of all groups were seen in tadalafil group, highest tissue TAOC values were observed in group given erythropoietin. CONCLUSION: It was concluded that by decreasing oxidative stress, tadalafil and erythropoietin can inhibit secondary damage in SCI.