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Öğe TURKISH RADIOLOGIC SOCIETY BREAST IMAGING GROUP STANDARTS FOR BREAST CANCER SCREENING(Aves, 2012) Aribal, Erkin; Tuncbilek, Nermin; Celik, LeventBreast cancer is common in Turkey and the most common cause of death from cancer in women. There is not a written guide in Turkey for breast cancer screening. The first trials about mamographic screening were started in 1960's in the Western countries. The results of 8 randomised controlled trials and screening programs in these countries showed that early detection of breast cancer has reduced breast cancer mortality. The information from these experiences and knowledge in the literature show that annual mammography screening in women over the age of 40 is the most effective method. However, in national screening programs, the aim to ensure optimal benefit in respect of the resources of the country, may cause the need for different screening policies which may not correspond exactly with this guide. This guide was created on behalf of the Turkish Society of Radiology Breast Radiology Group, and recommendations for screening of healthy women and women at risk for breast cancer were established in the light of scientific data.Öğe The value of MRI contrast enhancement in biopsy decision of suspicious mammographic microcalcifications: a prospective multicenter study(Springer, 2021) Taskin, Fusun; Kalayci, Cem Burak; Tuncbilek, Nermin; Soydemir, Efe; Kurt, Nazmi; Kaya, Handan; Aribal, ErkinObjectives To investigate the inclusion of breast MRI in radiological assessment of suspicious, isolated microcalcifications detected with mammography. Methods In this prospective, multicenter study, cases with isolated microcalcifications in screening mammography were examined with dynamic contrast-enhanced MRI (DCE-MRI) before biopsy, and contrast enhancement of the relevant calcification localization was accepted as a positive finding on MRI. Six experienced breast radiologists evaluated the images and performed the biopsies. Imaging findings and histopathological results were recorded. Sensitivity, specificity, NPV, and PPV of breast MRI were calculated and compared with histopathological findings. Results Suspicious microcalcifications, which were detected by screening mammograms of 444 women, were evaluated. Of these, 276 (62.2%) were diagnosed as benign and 168 (37.8%) as malignant. Contrast enhancement was present in microcalcification localization in 325 (73.2%) of the cases. DCE-MRI was positive in all 102 invasive carcinomas and in 58 (87.9%) of 66 DCIS cases. MRI resulted in false negatives in eight DCIS cases; one was high grade and the other seven were low-to-medium grade. The false-negative rate of DCE-MRI was 4.76%. The sensitivity, specificity, PPV, and NPV for DCE-MRI for mammography-detected suspicious microcalcifications were 95.2%, 40.2%, 49.2%, and 93.3%, respectively. Conclusions In this study, all invasive cancers and all DCIS except eight cases (12.1%) were detected with DCE-MRI. DCE-MRI can be used in the decision-making algorithm to decrease the number of biopsies in mammography-detected suspicious calcifications, with a tradeoff for overlooking a small number of DCIS cases that are of low-to-medium grade.