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    Frequency of gallstones after renal transplantation and factors that affect gallstone formation
    (John Wiley & Sons Inc, 2007) Celik, Aykut Ferhat; Altiparmak, Mehmet Riza; Pamuk, Guelsuem Emel; Pamuk, Oemer Nuri; Apaydin, Sueheyla
    BACKGROUND: We investigated the frequency of gallstones (GSs) in our renal transplant recipients and evaluated the effects of various factors on GS formation. METHODS: One hundred and eight-two patients who had undergone renal transplantation at our center in the last 12 years were included in the study. Of these, 163 patients were followed up regularly, of whom 118 were using cyclosporine A (CsA). Abdominal ultrasonography of all patients was performed, and biochemical parameters were also determined. RESULTS: Median duration of patient follow-up was 36 months. GSs were diagnosed in 5 patients (3.1%). Mean age and follow-up duration of the CsA group were lower than those of the non-CsA group (p < 0.05 and p < 0.001, respectively). The frequency of GSs was 3.4% in the CsA group and 2.2% in the non-CsA group (p > 0.05). Median time to detect GS formation in the post-transplantation period was 85 months. The CsA group had a significantly shorter GS-free follow-up period than the non-CsA group (p = 0.008). According to Cox multivariate regression analysis, the only factor that affected GS formation in the post-transplantation period was the use of CsA. CONCLUSION: The use of CsA showed a trend toward increasing the risk of developing a GS sooner in the post-transplant period, particularly for young men.