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    Efficacy of Alpha-methyldopa and Nifedipine in the Treatment of Postpartum Hypertension
    (Galenos Yayincilik, 2005) Sayin, N. Cenk; Altunda, Gonul; Varol, Fusun G.
    Objective: To evaluate the efficacy of alpha-methyldopa and nifedipine on postpartum hypertension in women who had various hypertensive disorders of pregnancy. Materials and Methods: A total of 83 women with preeclampsia, eclampsia and superimposed preeclampsia on chronic hypertension who had delivered in our department and also exhibited persistent hypertension over 160/110 mmHg after the postpartum 24th hours were included in the study. The patients were randomly divided into two groups. The patients in Group 1 (n=41) received alpha-methyldopa (750 mg/d) and in Group 2 (n=42) nifedipine (40 mg/d) in divided doses. Another antihypertensive drug was added to the therapy if the therapy was insufficient, and a third if needed. Antihypertensive therapy was discontinued after normotensive values were observed after 48 hours during therapy. The number of drugs were lessened and then discontinued in women taking two or more antihypertensive drugs. Mann-Whitney U and Chi-squaretests were applied for statistical analysis. Results: The patients were 17 to 41 years old, and the mean +/- SD age was similar between two groups (28.1 +/- 5.9 vs. 27.1 +/- 5.9 years, P=0.48). Women in Group 1 required antihypertensive therapy for 8.6 +/- 5.5 days, whereas Group 2 patients required therapy for 6.7 +/- 2.5 days (P=0.13). Twenty-one patients (51.2%) taking alpha-methyldopa did not need another antihypertensive drug, however 19 women (46.3%) received two and one patient (2.4%) received three different antihypertensive drug combinations. Twenty-nine patients (69%) taking nifedipine did not need another antihypertensive drug, however 11 women (26.1%) received two and two patients (4.7%) received three different antihypertensive drug combinations. There was no significant difference in single agent (P=0.15), double agent (P=0.09) or triple agent (P=1) antihypertensive therapy between two groups. Conclusion: Nifedipine and alpha-methyldopa treatment had similar effectiveness on postpartum hypertension in women with various hypertensive disorders of pregnancy. Also, the required duration of antihypertensive therapy was short.