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    Conjoined Twins: Unicephalus Non-Janiceps Tetrapus Tetrabrachius
    (Springer India, 2022) Yener, Cem; Sayin, N. Cenk; Altan, Esra; Varol, Fusun
    Conjoined twins are an uncommon type of monoamniotic twins with an incidence of about 1.5 per 100,000 births worldwide. Non-janiceps is the extremely rare sub-type of cephalopagus which is reported as 1 in 58 of all conjoined twins or 1 in 3 million births. We present a G6, P5 31-year-old pregnant who was diagnosed with a unicephalus non-janiceps conjoined twins. Due to its incompatibility with life, the pregnancy was electively terminated. The prognosis of conjoined twins depends on the location and extent of the conjoined area and the accompanying congenital anomalies of the fetuses. Early diagnosis is vital because it can help in assessing the type of conjoined twins and subsequently pre-postnatal decision making. Elective termination of non-janiceps type of conjoined twins which is incompatible with life is a justifiable possibility.
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    Letter to the editor related to the article Surgical outcomes of cesarean scar pregnancy: an 8-year experience at a single institution published by Xu et al.
    (Springer Heidelberg, 2022) Yener, Cem; Sayin, Cenk; Inan, Cihan; Altan, Esra; Ates, Sinan; Varol, Fusun
    [Abstract Not Available]
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    MEASUREMENT OF FETAL NASAL BONE LENGTH, PRENASAL THICKNESS AND CORPUS CALLOSUM LENGTH OF FETUSES IN THRACE REGION OF TURKEY
    (2020) Varol, Füsun; Yener, Cem; Sütçü, Havva; Altan, Esra; Ateş, Sinan; Sayın, Cenk
    Aim: The nasal bone can be imaged with ultrasonography from the 10th week of pregnancy. In situations where the nasal bone isaplastic or hypoplastic, the risk of chromosomal anomalies increases. Thickening of the prenasal soft tissue is also apparent in the vastmajority of second-trimester fetuses with Down syndrome. In addition to these, corpus callosum is an another fetal structure that can bevisualized from 18th weeks of the gestation by ultrasound. Agenesis or dysgenesis of it is related with neuro-disabilities. In this study ourobjective was to provide reference charts for fetal nasal bone length, prenasal thickness and corpus callosum length obtained byprenatal sonography between 19th and 23rd weeks of pregnancy.Materials and Methods: The medical records of pregnant women who were followed-up in Trakya University School of Medicine,Department of Obstetrics & Gynecology, Division of Perinatology during the time period of 1st of January 2018 to 31st of December2019 were reviewed retrospectively. We studied 167 patients in between 19th and 23rd weeks of pregnancy.Results: Nasal bone length, prenasal thickness and corpus callosum length increased as the gestation proceeded. Mean±SD for nasalbone length, prenasal thickness and corpus callosum length (mm) between 19th and 23rd weeks were 6.65±0.7, 4±0.5, 20.1±1.4respectively.Conclusion: Ultrasound measurements of nasal bone length, prenasal thickness and corpus callosum can be performed within thesecond-trimester anomaly scan, and these measurements appear to be highly necessary because these measurement sensitive forprenatal diagnosis of chromosomal abnormalities and genetic syndromes.
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    Prenatal diagnosis of 20p13 microdeletion syndrome
    (Elsevier Taiwan, 2021) Yener, Cem; Say, Cenk; Inan, Cihan; Gurkan, Hakan; Atli, Emine Ikbal; Atli, Engin; Altan, Esra
    Objective: The objective of this study was to report the first case of prenatal diagnosis of the fetal 20p13 microdeletion syndrome in the literature. Case report: The mother was 31 years old and had a first trimester serum screening that indicated the fetus was at low risk. The prenatal ultrasound at 23 weeks of gestation showed mild ventriculomegaly (10.2 mm) and absent septum pellucidum. She underwent amniocentesis because of the abnormal imaging results. Karyotype analysis revealed normal results. Chromosome microarray analysis (CMA) was then performed to provide genetic analysis of the fetus and parents. CMA detected 317.902 kb deletion of 20p13 in fetus. Finally, pregnancy was terminated at 32 weeks of gestation. Conclusion: This study is the first to report the prenatal diagnosis of a 20p13 microdeletion syndrome. Our results further confirmed that genes in this region, including SOX12, NRSN2 are essential for normal fetal growth and TBC1D20 for normal brain development. (c) 2021 Taiwan Association of Obstetrics & Gynecology. Publishing services by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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    Quadruplet Pregnancy with Complete Mole and Three Viable Fetuses
    (Taylor & Francis Inc, 2022) Yener, Cem; Sayin, N. Cenk; Keskin, Fatma Elif Usturali; Altan, Esra; Ates, Sinan; Varol, Fusun
    Background: The coexistence of a hydatidiform mole and a fetus can occur in a multiple pregnancy, being less frequent in triplets and quadruplets because of their infrequency. With assisted reproduction, multiple pregnancies are becoming more frequent, and we can expect more frequent coexistence with a molar pregnancy. Case report: This G3, P1 30-year-old mother, after assisted conception, was diagnosed with a quadruplet pregnancy, one of which was a molar conceptus. Due to the potential for malignancy, the pregnancy was electively terminated. Conclusion: Despite the difficulty in conceiving, elective termination of a multiple pregnancy associated with a molar pregnancy may be the most judicious course of action to protect the mother's life.