Yazar "Altan, A" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim Yok
    Öğe
    Effect of collateral circulation on healing of small intestinal anastomosis in rabbits
    (H G E Update Medical Publishing S A, 1997) Altan, A; Cakir, E; Kayapinar, R; Gega, F
    Background/Aims: In patients who have acute superior mesenteric artery occlusion and clearly gangrenous intestines, resection and anastomosis have been advised as the only surgical procedure. Distal and proximal bowel segments adjacent to this necrotic part have collateral blood supply although they have normal macroscopic appearance. After resection of necrotic segment, there will be a lore flow at the anastomosis due to collateral circulation and the healing may therefore be impaired. Methodology: This situation was investigated in rabbits creating unilateral collateral circulation at the small bowel anastomosis. Bursting pressure, tissue hydroxyproline concentration and bursting sites were determined on days 4, 8, and 12. Findings were compared with the those of normal anastomosis. Results: There was significantly decreased mean bursting pressure(106+/-40.3 mmHg) in unilateral collateral circulation group as compared with the that of control group (158+/-26.6 mmHg) on day 8 (p<0.05). On the same day mean hydroxyproline concentration of this group was also lower(7.06+/-0.5 mg/g tissue) than the value of control group(7.69+/-0.4 mg/g tissue), with the statistical significance on the border line(p=0.05). The low values of these two parameters reached normal levels on day 12, Bursting sites Lc)ere mostly on the anastomotic line in unilateral collateral circulation group, while they were mostly on the bowel wall in the control group on day 8. Conclusion: These findings suggest an insufficient healing process in the bowel anastomosis with unilateral collateral circulation on day 8 in rabbits.
  • Küçük Resim Yok
    Öğe
    Role of TIMP-2 in fascia transversalis on development of inguinal hernias
    (Taylor & Francis Inc, 2005) Abci, I; Bilgi, S; Altan, A
    The exact reason for the development of inguinal hernia has not been completely determined. However, it is known that the fascia transversalis ( FT) is one of the structures preventing development of hernias. In the etiology of the inguinal hernia, disorders in collagen metabolism have been proposed, and the role of metalloproteinases in remodeling the collagen has recently been of great importance. We could not encounter any study where the role of metalloproteinase inhibitors was evaluated in inguinal hernia. We obtained samples of FT from patients with direct and indirect hernia and used an immunohistochemical method to determine tissue inhibitor of metalloproteinase-2 ( TIMP-2) expression. In the study group, samples of FT were taken during the operation from 45 patients, of which 35 were indirect and 10 were direct inguinal hernias. In the control group, samples of FT from various abdominal incisions were also taken from 45 patients with no hernia and operated upon for another pathology. TIMP-2 scores of a direct inguinal hernia were significantly less than those of the control group. However, no difference has been found between the TIMP-2 scores of an indirect inguinal hernia and those of the control group. Decreased TIMP- 2 scores in patients with a direct inguinal hernia, compared with both the indirect inguinal hernia group and the control group, explain the reason for the increase in matrix metalloproteinase-2 ( MMP-2) that has been proposed in some studies. Therefore, it can be expressed that a decreased activity of TIMP- 2 plays a role in inguinal hernia development.