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Öğe Akut koroner sendrom ve stabil angina pektorisli hastalarda osteoprotegerin düzeyleri ile koroner arter hastalığının yaygınlığı ve geç dönem prognoz arasındaki ilişki(Trakya Üniversitesi Tıp Fakültesi, 2009) Aksu, Feyza; Özçelik, FatihBu çalışma stabil angina pektoris ve anstabil angina pektoris / ST elevasyonsuz miyokard infarktüslü hastalarda serum osteoprotegerinin koroner arter hastalığının tanısı, yaygınlığı ve prognozundaki yerini değerlendirmek için yapıldı. Çalışmaya 30 kontrol grubu, 65 stabil angina pektoris grubu, 65 akut koroner sendrom grubu olmak üzere toplam 160 kişi alındı. Sonrasında 4. ayda kontrol izlemleri yapıldı. Stabil angina pektoris grubundan 4 hastaya, akut koroner sendrom grubundan 3 hastaya 4 ay sonrasında ulaşılamadı. Akut koroner sendrom grubundan 7 hastada takip süresinde ölüm gerçekleşti. Tüm hastalardan yatışlarının 1. saatinde, akut koroner sendrom grubundaki hastalardan ek olarak 24. saatte ve 5. günde osteoprotegerin için kan alındı. Kontrol gurubu ile stabil angina grubu ve kontrol grubu ile akut koroner sendrom grubu arasında 1. saat osteoprotegerin düzeylerinde istatistiksel olarak anlamlı farklılık vardı (sırasıyla p<0,01 ve p<0,001). Akut koroner sendrom grubunda 1. saat, 24. saat ve 5. gün osteoprotegerin düzeyi giderek azalmakta olup, arasında istatistiksel anlamlılık yoktu (p=0,538). 247,71 pg/ml değeri cut-off olarak alındığında bu değerin üzerindeki 1. saat osteoprotegerin düzeylerinin koroner arter hastalığını göstermedeki duyarlılığı %91,54, özgüllüğü %46,67, pozitif prediktif değeri %88,1, negatif prediktif değeri %56 olarak bulundu. 1. saat, 24. saat ve 5. gün osteoprotegerin değerleriyle Gensini değerleri arasında da korelasyon bulunmadı. Osteoprotegerin düzeyi ile hastalıklı koroner arter damar sayısı arasında ilişki gösterilmedi. Çalışmamız, stabil angina pektoris ve anstabil angina pektoris / ST elevasyonsuz miyokard infarktüslü hastalarda serum osteoprotegerinin koroner arter hastalığının şiddeti ya da yaygınlığı ile ilişkili olmadığını ve prognostik bir önem taşımadığını sadece koroner arter hastalığının bir belirteci olduğunu göstermektedir.Öğe Antioxidant and renoprotective effects of sphingosylphosphorylcholine on contrast-induced nephropathy in rats(Taylor & Francis Ltd, 2016) Aksu, Feyza; Aksu, Burhan; Unlu, Nermin; Karaca, Turan; Ayvaz, Suleyman; Erman, Hayriye; Uzun, HafizeContrast induced nephropathy (CIN) is a major cause of morbidity, and increased costs as well as an increased risk of death. This study was evaluated effects of exogenous sphingosylphosphorylcholine (SPC) administration on CIN in rats. Eight animals were included in each of the following eight groups: control, control phosphate-buffered solution (PBS), control SPC 2, control SPC 10, CIN, CIN PBS, CIN SPC 2 and CIN SPC 10. The induced nephropathy was created by injected with 4g iodine/kg body weight. SPC was administered 3d at a daily two different doses of 2m/mL and 10m/mL intraperitoneally. The severity of renal injury score was determined by the histological and immunohistochemical changes in the kidney. Malondialdehyde (MDA), nitric oxide (NO) and superoxide dismutase (SOD) were determined to evaluate the oxidative status in the renal tissue. Treatment with 2 and 10M SPC inhibited the increase in renal MDA, NO levels significantly and also attenuated the depletion of SOD in the renal injuryCIN. These data were supported by histopathological findings. The inducible nitric oxide synthase positive cells and apoptotic cells in the renal tissue were observed to be reduced with the 2 and 10M SPC treatment. These findings suggested that 2 and 10M doses can attenuate renal damage in contrast nephropathy by prevention of oxidative stress and apoptosis. The low and high dose SPC may be a promising new therapeutic agent for CIN.Öğe A Case of Uncorrected Tetralogy of Fallot Presenting with Acute Ischemic Stroke(Aves, 2014) Tekatas, Aslan; Kehaya, Sezgin; Cagli, Bekir; Akdemir, Vedat; Aynaci, Ozer; Dogru, Yuce; Aksu, FeyzaTetralogy of Fallot (FT) is the most common cyanotic congenital heart disease. FT is mainly composed of ventricular septal defect, right ventricular outflow tract obstruction, pulmonary stenosis and right ventricular hypertrophy, but also can include dextrapositioned aorta (overriding aorta), additional malformations such as atrial septal defect, and coronary artery anomalies. In the first week of life patients undergo palliative anastamosis between a pulmonary artery and subclavian artery and after they become eligible for major surgery total correction isperformed. With neurological involvement ischemic or venous stroke, syncope and seizures can occur. Generally, clinical presentation is cerebral venous thrombosis. IIschemic stroke in children is associated with hyperviscosity and microstasis, and in adults with phlebotomy, microcytosis and traditional stroke risc factors such as hypertension, diabetes mellitus and cardiac rhythm disorders. Patients with uncorrected FT rarely survive adulthood. In this study, we present a case without total correction, who lived up to the age of 39 years and presented with arterial stroke instead of expected venous thrombosis, along with stroke mechanisms in the literature.Öğe Demonstration of a persistent left superior vena cava by transthoracic echocardiography using agitated saline injection(Pulsus Group Inc, 2007) Erdogan, Okan; Aksu, Feyza; Birsin, Atilla[Abstract Not Available]Öğe Effects of sphingosylphosphorylcholine against oxidative stress and acute lung injury induced by pulmonary contusion in rats(W B Saunders Co-Elsevier Inc, 2015) Aksu, Burhan; Ayvaz, Suleyman; Aksu, Feyza; Karaca, Turan; Cemek, Mustafa; Ayaz, Ahmet; Demirtas, SelimBackground/purpose: The goal of this study was to evaluate effects of exogenous sphingosylphosphorylcholine (SPC) administration on acute lung injury induced by pulmonary contusion in rats. Methods: Eight animals were included in each of the following five groups: control, contusion, contusion phosphate-buffered solution (PBS), contusion SPC 2, contusion SPC 10. SPC was administered 3 days at a daily two different doses of 2 mu m/ml and 10 mu m/ml intraperitoneally. The severity of lung injury was determined by the neutrophil activation and histological and immunohistochemical changes in the lung. Malondialdehyde (MDA), nitric oxide (NO), superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione (GSH) were determined to evaluate the oxidative status in the lung tissue. Results: Treatment with 2 mu M SPC inhibited the increase in lung MDA and NO levels significantly and also attenuated the depletion of SOD, GPx, and GSH in the lung injury induced by pulmonary contusion. These data were supported by histopathological findings. The inducible nitric oxide synthase (iNOS) positive cells and apoptotic cells in the lung tissue were observed to be reduced with the 2 mu M SPC treatment. But, the 10 mu M SPC treatment did not provide similar effects. Conclusions: In conclusion, these findings suggested that 2 mu M SPC can attenuate lung damage in pulmonary contusion by prevention of oxidative stress, inflammatory process and apoptosis. All these findings suggest that low dose SPC may be a promising new therapeutic agent for acute lung injury. (C) 2015 Published by Elsevier Inc.Öğe R-R interval variation and sympathetic skin response in systemic lupus erythematosus(Springer London Ltd, 2014) Tekatas, Aslan; Koca, Suleyman Serdar; Tekatas, Demet Deniz; Aksu, Feyza; Dogru, Yuce; Pamuk, Omer NuriThe involvement of the autonomic nervous system is less common than that of the central and peripheral nervous system in systemic lupus erythematosus (SLE) patients. However, its involvement can negatively affect the quality of life of the patient and cause life-threatening situations. In this study, autonomic function was evaluated in SLE patients who did not show any sign of autonomic involvement using R-R interval variation (RRIV) and sympathetic skin response (SSR) electrophysiological tests. SSR was used to evaluate the sympathetic nervous system, whereas RRIV was used for the parasympathetic nervous system. We included 23 SLE patients and 21 healthy volunteers in the study. Of the 23 SLE patients, 20 (86.9 %) were female and 3 (13.1 %) were male. The age range of the patients was between 19 and 52 years, with a mean age of 32.5 +/- 9.1 years. Routine nerve conduction studies and autonomic tests were performed on patients in the electromyography (EMG) laboratory. Lower extremity SSR latencies were prolonged and a significant loss of amplitude was observed in comparison to the control group. Furthermore, deep-breath RRIV values for the patient group were significantly lower than that of the control group. Both sympathetic and parasympathetic nervous system involvement was seen in our study. In conclusion, EMG can reveal a possible underlying involvement in the absence of signs of autonomic involvement.Öğe The relation between the levels of osteoprotegerin and the degree of coronary artery disease in patients with acute coronary syndrome and stable angina pectoris(Via Medica, 2014) Aksu, Feyza; Ozcelik, Fatih; Kunduracilar, Hakan; Barutcu, Ahmet; Yel, Mesih; Umit, Elif Gulsum; Altun, ArmaganBackground: Osteoprotegerin (OPG), an inhibitor of osteoclastogenesis, has recently been under the spotlight in studies regarding the pathophysiology of atherosclerosis. Aim: To evaluate the value of serum OPG in the diagnosis and severity in patients with stable angina pectoris (SA) and unstable angina pectoris/non ST elevation myocardial infarction. Methods: This study involved 160 patients, SA (n = 65), acute coronary syndrome (NSTE-ACS; n = 65), and a control group (n = 30). Blood samples were collected in the first hour, after 24 hours and on the fifth day. The prevalence of coronary artery atherosclerotic lesions was determined using the Gensini scoring system. Results: A statistically significant difference was observed in the first hour OPG levels between the control group and both the SA and NSTE-ACS group (p < 0.001). When the cut-off value was determined as 247.71 pg/mL, the sensitivity and specificity of the first hour OPG levels indicating coronary artery disease were 91.54% and 46.67%, respectively, while the positive predictive value was 88.1% and the negative predictive value was 56%. No correlations were observed between the first, 24th hour and the fifth day OPG levels and the Gensini scores. No relation was denoted between the OPG levels and number of diseased coronary arteries. Conclusions: In our study, serum OPG level seemed to be unrelated to the severity or the degree of coronary artery disease in patients with SA and unstable angina pectoris/non ST elevation myocardial infarction. OPG may only be accepted as an indicator of coronary artherosclerosis.Öğe Tam Düzeltme Yapılmamış Fallot Tetralojili Olguda Akut İskemik İnme(2014) Tekataş, Aslan; Kehaya, Sezgin; Çağlı, Bekir; Akdemir, Vedat; Aynacı, Özer; Doğru, Yüce; Aksu, FeyzaFallot Tetralojisi (FT) en sık gözlenen konjenital siyanotik kalp hastalığıdır.FT temel olarak ventriküler septal defekt, sağ ventrikül çıkış yolu obstriksiyonu,pulmoner stenoz ve sağ ventrikül hipertrofisini içermekle beraberayrıca dekstropoze aorta (ata binen aorta), atrial septal defekt ve korenerarter anomalileri gibi ek malformasyonlar da eşlik edebilir. Hastalara yaşamınilk haftasında pulmoner arter ile subklavian arter arasında paliatifolarak anastamoz yapılıp ve major cerrahiyi kaldırabilecek durumageldikten sonra total düzeltme ameliyatı yapılır. Nörolojik tutulum olarakhastalarda atreriel veya venöz inme, senkop ve nöbetler ortaya çıkabilir.Genellikle klinik tablo serebral venöz tombozdur. İnme çocuklarda hiperviskositeve mikrostaz ile ilişkilendirilmiş iken erişkinlerde ise flebotomi,mikrositoz, hipertansiyon, diabetes mellitus ve ritim bozuklukları gibigeleneksel inme risk faktörleri ilişkilendirilmiştir. Erişkin yaşlarda düzeltilmemişFT'li hastalara nadiren rastlanır. Bu çalışmada tam düzeltmeoperasyonu geçirmeden 39 yaşına kadar yaşayabilen ve çoğunlukla beklenentablo olan venöz inmenin yerine arteriyel inme gelişen bir hasta olasıinme mekanizmaları literatür ışığında tartışılarak sunulmuştu.