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Öğe Brain SPECT findings in Wernicke's encephalopathy(Springer-Verlag Italia Srl, 2004) Çelik, Y; Kaya, MWernicke's encephalopathy, a neurologic disease caused by thiamine deficiency, is observed chiefly in chronic alcoholics. We performed magnetic resonance imaging and single-photon emission computed tomography (SPECT) in an alcoholic patient who had developed Wernicke's encephalopathy. Although cranial MRI detected no pathology, brain SPECT revealed bilateral frontal and frontoparietal hypoperfusion as well as right basal ganglia hypoperfusion.Öğe Factors affecting haemorrhagic transformation in middle cerebral artery infarctions(Churchill Livingstone, 2004) Çelik, Y; Utku, U; Asil, T; Balci, KObjective: Haemorrhagic transformation (HT) affects treatment and prognosis in patients with acute ischaemic stroke. The factors affecting haemorrhagic transformation in infarcts due to occlusion of middle cerebral artery (MCA) stem or branch were investigated. Materials and methods: Of 412 patients who were followed in our clinic between January 2001 and December 2001 with acute ischaemic stroke, 86 patients with occlusion in MCA stem or branch were enrolled in this study. These patients were divided into 2 groups, those with HT (n = 35) and without HT (n = 51). Age, sex, systemic arterial hypertension, diabetes mellitus, blood glucose level in the acute period, renal and liver function tests, systolic and diastolic arterial blood pressure in the acute period, previous cerebrovascular disease, leukoaraiosis, modified Rankin Disability Score (mRDS) and stroke subtype were evaluated. Results: High blood glucose level in the acute period and presence of leukoaraiosis on cranial computerized (CCT) tomography were detected as risk factors in development of HT. HT was seen more frequently in MCA stem infarction than branch infarction. mRDS were worse in the group with HT. In multivariate analysis, there were independent relationships between mean blood glucose level on admission, mRDS, presence of diabetes mellitus, and MCA stem infarction and development of haemorrhagic transformation in patients with MCA territorial infarction. (C) 2003 Elsevier Ltd. All rights reserved.Öğe Hepatic myelopathy with spastic paraparesis(Elsevier, 2005) Utku, U; Asil, T; Balci, K; Uzunca, I; Çelik, YProgressive myelopathy is a rare neurological complication of chronic liver disease with portal hypertension and there is no special diagnostic tool for hepatic myelopathy. Neuropathological studies of the patients with hepatic myelopathy have demonstrated demyelination of the lateral corticospinal tracts with various degree of axonal loss. Transcranial magnetic stimulation (TMS) is widely utilized as an indicator of changes in exitability and conductivity of the motor pathways. TMS studies are also used for the diagnosis of hereditary spastic paraparesis in the literature. In this study, we described two patients who presented with spastic paraparesis; TMS studies suggested that they had myelopathy and diagnosed as hepatic myelopathy when all the other possible diagnoses were ruled out. (c) 2004 Elsevier B.V. All rights reserved.Öğe Marchiafava-Bignami disease(Elsevier Science Bv, 2002) Çelik, Y; Kaya, M; Sengün, S; Utku, UMarchiafava-Bignami disease (MBD) associated with chronic alcoholism is a fatal disorder characterized by demyelination of the corpus callosum. It is diagnosed by the imaging of demyelination at the corpus callosum with MRI. This lesion is not only limited to the corpus callosum but also affects the cortico-cortical and cortico-subcortical projections due to disconnection and causes frontal lobe syndromes and dementia. In this article, we presented a case that MBD associated with chronic alcoholism. (C) 2002 Elsevier Science B.V. All rights reserved.Öğe Migraine prevalence and some related factors in Turkey(Wiley, 2005) Çelik, Y; Ekuklu, G; Tokuç, B; Utku, UObjectives.-The aim of our study is to determine the prevalence of migraine in Provincial Center of Edirne. Methods.-A systematic random sample of 386 inhabitants over 14 years old were interviewed face to face. Diagnosis of migraine was based on the International Headache Society (IHS) classification. Results.-Migraine was identified in 77 subjects (60 female, 17 male). The lifetime prevalence of migraine was found to be 19.9% (95% CI: 18.3-21.5) (9.34% (95% CI: 8.6-10) in males, 29.3% (95% CI: 27-31.6) in females). Conclusions.-These results show that while migraine prevalence in Turkish females is higher than that reported in previous studies from Europe and United States, lifetime prevalence is similar in all populations.Öğe Mitral valve vegetation and cerebral emboli in a primary antiphospholipid syndrome patient who had hepatitis C virus infection(Springer-Verlag, 2003) Pamuk, ÖN; Çakir, N; Soy, M; Aktoz, M; Çelik, Y; Akdemir, OWe report the case of 36-year-old woman who came to us with a history of recurrent miscarriages and who was later diagnosed as having primary antiphospholipid syndrome (PAPS) and chronic hepatitis C virus (HCV) infection. The patient was referred to us with generalised seizures; cranial MRI revealed multiple embolic infarcts in both frontal lobes and a focal cortical infarct in the left frontoparietal lobe. Her echocardiography showed mitral valve vegetation and insufficiency. The patient was put on oral anticoagulant therapy and during her 8-month follow-up period no thrombotic events occurred. We report this case because it was the first in which PAPS, valvular disease, a cerebral embolic event and HCV infection were coexistent in the same patient. We also review other cases in which there was valvular vegetation and a cerebral ischaemic event associated with PAPS.Öğe A primary Sjogren's syndrome patient with distal renal tubular acidosis, who presented with symptoms of hypokalemic periodic paralysis(Springer Heidelberg, 2005) Soy, M; Pamuk, ÖN; Gerenli, M; Çelik, YAlthough renal tubular acidosis (RTA), secondary to autoimmune interstitial nephritis, develops in a large proportion of patients with Sjogren's syndrome (SS), most of the subjects are asymptomatic. Here, we shall present a 39-year-old female patient who came to us with hypokalemic periodic paralysis (HPP), and who was later diagnosed with distal RTA. The patient, who had xerostomia and xerophthalmia for a long period of time, was diagnosed with primary SS from serologic and histologic findings. The patient recovered by being prescribed potassium replacement therapy. Although renal biopsy was not performed, corticosteroids were administered because HPP indicated severe interstitial nephritis. HPP did not reoccur during a 2-year follow-up period. We also review cases with SS-related distal RTA and HPP.Öğe Reversible MR angiographic findings in a patient with autoimmune Graves disease(Amer Soc Neuroradiology, 2004) Utku, U; Asil, T; Çelik, Y; Tucer, DA 45-year-old woman presented with subacute encephalopathy due to autoimmune Graves disease. MR angiography (MRA) demonstrated stenosis of the major intracerebral arteries. After high-dose methylprednisolone therapy and plasmapheresis, her neurologic status improved dramatically, and the MRA findings resolved after 3 months. The angiographic findings in Graves disease that resemble those in Moyamoya disease are temporary.Öğe Risk factors of status epilepticus in children(Wiley, 2003) Karasalihoglu, S; Öner, N; Çeltik, C; Çelik, Y; Biner, B; Utku, UBackground : Although there is abundant literature about the morbidity and mortality rates of status epilepticus (SE), little is known about the risk factors of this medical emergency. The aim of the present study is to assess the risk factors of SE in children. Methods : The authors reviewed the medical records of 83 patients admitted to the Pediatric Neurology Unit of Trakya University Hospital, Edirne, Turkey from January 1994 to December 2001 with the diagnosis of SE. Eighty-three patients were compared with 166 controls who were admitted to the same unit due to non-status epilepticus (non-SE) seizure. Results : The univariate analysis demonstrated that SE episodes were significantly associated with a history of birth asphyxia, neonatal seizure, discontinuation of antiepileptic medication, epilepsy, partial seizure evolving to secondary generalized seizures, myoclonic seizure, generalized abnormalities in the neurological examination, neuromotor retardation, generalized background abnormalities on electroencephalogram (EEG), generalized abnormalities on neuroimaging and polypharmacy than non-SE episodes. Logistic regression was used to test the independence of these parameters as predictors of SE risk. Four parameters emerged as significant independent predictors of SE in children in multiple logistic regression: polypharmacy (Odds ratio (OR) 5.17, P = 0.0004), discontinuation of antiepileptic medication (OR 4.04, P = 0.0095), neuromotor retardation (OR 4.03, P = 0.0016) and generalized background abnormalities on EEG (OR 2.48, P = 0.0419). Conclusion : Polypharmacy, discontinuation of antiepileptic medication, neuromotor retardation and generalized background abnormalities on EEG are indicators in children of a higher risk of SE.Öğe Transverse myelitis caused by Varicella(Elsevier Science Bv, 2001) Çelik, Y; Tabak, F; Mert, A; Çelik, AD; Aktuglu, Y[Abstract Not Available]Öğe Vasculitis and cerebral infarcts(B M J Publishing Group, 2003) Soy, M; Gerenli, M; Çelik, Y[Abstract Not Available]