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dc.contributor.authorAydinyurt, Hacer Sahin
dc.contributor.authorYuncu, Yusuf Ziya
dc.contributor.authorTekin, Yasin
dc.contributor.authorErtugrul, Abdullah Seckin
dc.date.accessioned2019-06-27T07:42:26Z
dc.date.available2019-06-27T07:42:26Z
dc.date.issued2018en_US
dc.identifier.citationSahin Aydınyurt, H., Yuncu, Y. Z., Tekin, Y., & Ertugrul, A. S. (2018). IL‐6, TNF–α levels and periodontal status changes during the menstrual cycle. Oral diseases, 24(8), 1599-1605.en_US
dc.identifier.urihttps://dx.doi.org/10.1111/odi.12917
dc.identifier.urihttp://dspace.trakya.edu.tr/xmlui/handle/trakya/4256
dc.descriptionTekin, Yasin (Trakya author)en_US
dc.description.abstractObjectives Sex steroid hormones are thought to affect periodontal tissues. A clear understanding of the effect of the menstrual cycle on oral tissues would be an important milestone in the timing of dental interventions in the future. The aim of this longitudinal, prospective study was to evaluate clinical periodontal parameters and levels of interleukin-6 IL-6 and tumour necrosis factor alpha (TNF-) in gingival crevicular fluid (GCF) during the menstrual cycle. MethodsResultsForty-five patients were included in this study. Clinical periodontal parameters and levels of IL-6 and TNF- were evaluated at three points of the menstrual cycle: menstruation day MD, ovulation day (OD) and premenstruation day (PmD). Levels of IL-6 and TNF- were determined by enzyme-linked immunosorbent assay. There were no statistically significant changes in plaque indexes or probing depths during the menstrual cycle (p>0.006) The differences between OD and PmD for gingival index and bleeding on probing were significant (OD>MD) (p<0.006). Statistically significant differences in TNF- and IL-6 levels in the GCF were observed during the menstrual cycle (PmD>OD>MD) (p<0.006). ConclusionsPeriodontal tissues did not exhibit evident changes, but this study demonstrated that the menstrual cycle affected the periodontium and induced inflammatory situations during the menstrual cycle.en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.identifier.doi10.1111/odi.12917en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCytokinesen_US
dc.subjectGingival Crevicular Fluiden_US
dc.subjectMenstrual Cycleen_US
dc.subjectPeriodonticsen_US
dc.subjectTumor-Necrosis-Factoren_US
dc.subjectGingival Crevicular Fluiden_US
dc.subjectSex-Hormonesen_US
dc.subjectInterleukin-6 Productionen_US
dc.subjectIn-Vitroen_US
dc.subjectCytokinesen_US
dc.subjectHealthen_US
dc.subjectInflammationen_US
dc.subjectFibroblastsen_US
dc.subjectModulationen_US
dc.titleIL-6, TNF-alpha levels and periodontal status changes during the menstrual cycleen_US
dc.typearticleen_US
dc.authoridhttp://orcid.org/0000-0002-9521-9704en_US
dc.departmentDiş Hekimliği Fakültesien_US
dc.identifier.volume24en_US
dc.identifier.issue8en_US
dc.identifier.startpage1599en_US
dc.identifier.endpage1605en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.relation.journalOral Diseasesen_US


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