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Struggle With Bonzai: a Review on Synthetic Cannabinoid Abuse
(Trakya Üniversitesi, 2014)Cannabis has been a widely favored recreational drug throughout history. It has also been used as medicine, due to its analgesic and anti-inflammatory effects. Following the discovery of its main ingredient, ?9-tetrahydr ... -
Cannabinoid Receptors Are Not Involved in Antinociception Induced by Systemic Diclofenac in Mice
(Trakya Üniversitesi, 2020)Aims: It has been long suspected that the cannabinoid system participates in the antinociceptive effects of nonsteroidal anti-inflammatory drugs. We studied the possible effects of cannabinoid receptor antagonism on ... -
Systemic Cannabidiol Does Not Reduce Compound 48/80-Induced Itching Behavior in Mice
(Trakya Üniversitesi, 2019)Aims: Cannabinoids are chemical compounds including natural cannabinoids found in the Cannabis plant, their synthetic counterparts, and endocannabinoids. Cannabidiol, a phytocannabinoid derived from the Cannabis plant, ... -
Plasma levels of asymmetric dimethylarginine and total homocysteine in first degree relatives of type 2 diabetic patients
(2007)Amaç: Tip 2 diyabetik hastaların birinci derece yakınlarında, ailesinde diyabet öyküsü olmayan sağlıklı olgulara göre kardiyovasküler hastalıklar daha sık görülmektedir. Asimetrik dimetilarginin (ADMA) ve homosistein (Hcy) ... -
Farelerde periferik nöropati için yeni bir deneysel model: Tibial sinir ligasyonu
(2006)Amaç: Farelerde gen manipülasyonunun kolayca yapılabilmesi nöropatik ağrının moleküler mekanizmalarının açıklığa kavuşması açısından büyük önem taşımaktadır. Ancak sıçanlara göre farelerde nöropatik ağrı modelleri oldukça ... -
Farelerde morfinin oluşturduğu analjezik etkide santral histaminerjik sistemin rolü
(2000)Amaç: Farelerde morfinin analjezik etkilerine aracılık eden histaminin kaynağının santral histaminerjik nöronlardan salınan histamin mi, yoksa mast hücrelerinin içerdiği histamin mi olduğu araştırıldı. Gereç ve Yöntem: Bu ... -
Non-opioid Analgesics and the Endocannabinoid System
(2020)Non-steroidal anti-inflammatory drugs produce antinociceptive effects mainly through peripheral cyclooxygenase inhibition. In opposition to the classical non-steroidal anti-inflammatory drugs, paracetamol and dipyrone exert ... -
The endocannabinoid system as a potential therapeutic target for pain modulation
(2014)Although cannabis has been used for pain management for millennia, very few approved cannabinoids are indicated for the treatment of pain and other medical symptoms. Cannabinoid therapy re-gained attention only after the ...