Scopus İndeksli Yayınlar Koleksiyonu
http://dspace.trakya.edu.tr/xmlui/handle/trakya/5364
Scopus Indexed Publications Collection2024-03-29T08:17:16ZAntimicrobial and toxicity profiles evaluation of the Chamomile (Matricaria recutita L.) essential oil combination with standard antimicrobial agents
http://dspace.trakya.edu.tr/xmlui/handle/trakya/4969
Antimicrobial and toxicity profiles evaluation of the Chamomile (Matricaria recutita L.) essential oil combination with standard antimicrobial agents
Goger, Gamze; Demirci, Betul; Ilgin, Sinem; Demirci, Fatih
In this present study, commercial Pharmacopeia (PhEur) grade chamomile essential oil (Mairicariae aetheroleurn) was combined with different antimicrobial agents including ampicillin sodium, cefuroxime acetyl, tetracycline hydrochloride, fluconazole and nystatin. All combinations were evaluated in vitro against pathogenic standard and clinical resistant Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) bacterial isolates as well as against Candida albicans for their broad antimicrobial effectiveness. Furthermore, the essential oil was fractioned by column chromatography using n-hexane, diethyl ether, dichloromethane and methanol, respectively. Additionally, all fractions of essential oil were tested in combinations for their minimum inhibitory concentrations (MIC) as well as for their fractional inhibitory concentrations (FIC) against the resistant microbial pathogens. Antimicrobial activities were evaluated by microdilution method and antimicrobial interactions were assayed using the checkerboard method. Cytotoxicity of compounds were evaluated using Cytotox-XTT-1 1:rameter Kit in WS1 cells and Aliivibrio fischeri bioluminescence toxicity assay. The analyses proved that alpha-bisabolol oxide A (47.7%), (E)-beta-famesene (21.5%), alpha-bisabolol oxide B (6.2%), alpha-bisabolone oxide A (5.8%), chamazulene (4.1%) and alpha-bisabolol (2.2%), respectively were the major compounds and in compliance with PhEur. The essential oil combination of fluconazole and nystatin showed "synergic and additive inhibitory effects" against the clinical Candida strain. According to the IC50 values obtained, the inhibitory concentrations of combinations against the clinical Candida strain can be considered to be selective when compared with its effect on WS1 cells. Additionally, the essential oil combination of fluconazole and nystatin showed low toxicity against A. fischeri.
2018-01-01T00:00:00ZThe effect of carbonization temperature, carbonization time and impregnation ratio on the properties of activated carbon produced from Arundo donax
http://dspace.trakya.edu.tr/xmlui/handle/trakya/4968
The effect of carbonization temperature, carbonization time and impregnation ratio on the properties of activated carbon produced from Arundo donax
Uner, Osman; Bayrak, Yuksel
Activated carbons from Arundo donax were obtained by varying impregnation ratio, carbonization time, and carbonization temperature via chemical activation method. By operating impregnation ratio as 1.5 and carbonization temperature as 400 degrees C, the activated carbons with the highest surface areas were produced. Under this operating condition, the surface areas were measured to be 1784, 1781, and 1785 m(2)/g when the carbonization times were 60, 90, and 120 min, respectively. N, adsorption-desorption isotherms are generally Type I and Type IV isotherm mixtures, but when sufficient thermal energy at carbonization process is given and the chemical activation ratio is increased, N-2 adsorption-desorption isotherms are more likely to resemble Type IV isotherms. Also, H4 type hysteresis in the N-2 adsorption-desorption isotherms proves that activated carbons have micromesopore structures, and the pore shapes are usually cylindrical. Moreover, the resultant activated carbons were characterized by using pore size distributions, elemental analysis, SEM and FTIR.
2018-01-01T00:00:00ZThe impact of auditor education level on the relationship between auditor busyness and audit quality in Turkey
http://dspace.trakya.edu.tr/xmlui/handle/trakya/4967
The impact of auditor education level on the relationship between auditor busyness and audit quality in Turkey
Ocak, Murat
In this study, I examine the effect of auditor education level on the relationship between auditor busyness and audit quality using Turkish listed firms. Prior studies regarding auditor busyness have not considered how auditor busyness affects audit quality in the case of auditors who are less educated or more educated. I created some interaction variables using busyness and auditor education level. Additionally, the sample was split into two groups based on auditor education level. The main estimation results show that auditor busyness (auditor education level) negatively (positively) affects audit quality. Auditor formal education level minimises the negative effect of auditor busyness on auditor quality. Also, I found that the negative effect of auditor busyness on audit quality is more pronounced in the case of less educated auditors.
2018-01-01T00:00:00ZLayer-specific strain analysis in patients with suspected stable angina pectoris and apparently normal left ventricular wall motion
http://dspace.trakya.edu.tr/xmlui/handle/trakya/4966
Layer-specific strain analysis in patients with suspected stable angina pectoris and apparently normal left ventricular wall motion
Yilmaztepe, Mustafa Adem; Ucar, Fatih Mehmet
Background: Non-invasive imaging tests are widely used in the evaluation of stable angina pectoris (SAP). Despite these tests, non-significant coronary lesions are not a rare finding in patients undergoing elective coronary angiography (CAG). Two-dimensional (2D) speckle tracking global longitudinal strain (GLS) imaging is a more sensitive and accurate technique for measuring LV function than conventional 2D methods. Layer-specific strain analysis is a relatively new method that provides endocardial and epicardial myocardial layer assessment. The aim of the present study was to evaluate longitudinal layer-specific strain (LSS) imaging in patients with suspected SAP.
Methods: Patients who underwent CAG for SAP were retrospectively screened. A total of 79 patients with no history of heart disease and wall motion abnormalities were included in the study. Forty-three patients with coronary lesions > 70% constituted the coronary artery disease (CAD) group and 36 patients without significant CAD constituted the control group. Layer-specific GLS transmural, endocardium, and epicardium values (GLS-trans, GLS-endo, and GLS-epi, respectively) were compared between the groups.
Results: Patients in the CAD group had significantly lower GLS values in all layers (GLS-trans: -18.2 + 2.4% vs -22.2 + 2.2% p <.001; GLS-endo: -20.8 + 2.8% vs -25.3 + 2.6%, p < .001; GLS-epi: 15.9 + 2.4% vs -19.5 + 1.9%, p < .001). Multivariate adjustment demonstrated GLS-trans as the only independent predictor of CAD (OR:0.472, CI (0.326-0.684), p < .001]. Additionally, the GLS values were all lower in myocardial perfusion scintigraphy (MPS) true-positive patients compared with MPS false-positive patients (GLS-trans: -17.7 +/- 2.4 vs. -21.9 +/- 2.4%, p < .001; GLS-endo: -20.2 +/- 2.9% vs -24.9 +/- 2.9%, P < .001; GLS-epi: 15.4 +/- 2.6% vs. -19.2 +/- 1.8%, P < .001).
Conclusion: Resting layer-specific strain as assessed by 2D speckle tracking analysis demonstrated that GLS values were reduced in all layers of myocardium with SAP and with no wall motion abnormalities. LSS analysis can improve the identification of patients with significant CAD but further prospective larger scale studies are needed to put forth the incremental value of LSS analysis over transmural GLS.
2018-01-01T00:00:00Z